2015
DOI: 10.1016/j.toxlet.2014.10.013
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Phenylbutyric acid inhibits epithelial-mesenchymal transition during bleomycin-induced lung fibrosis

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Cited by 47 publications
(38 citation statements)
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“…Although 4-PBA has multiple activities -including inhibiting HDACs and scavenging ammonia -it also acts as an osmolyte chemical chaperone to rescue conformational abnormalities of proteins 177 . 4-PBA is reported to improve bleomycininduced lung fibrosis and to decrease the expression of ER stress markers, collagen and αSMA 178 . Although targeting the ER stress response seems promising as a future therapy for lung diseases, there is limited knowledge of how to specifically control UPR pathways that activate both pro-survival adaptive responses and cell death.…”
Section: Targets and Therapeutic Interventions For Insufficient Protementioning
confidence: 98%
“…Although 4-PBA has multiple activities -including inhibiting HDACs and scavenging ammonia -it also acts as an osmolyte chemical chaperone to rescue conformational abnormalities of proteins 177 . 4-PBA is reported to improve bleomycininduced lung fibrosis and to decrease the expression of ER stress markers, collagen and αSMA 178 . Although targeting the ER stress response seems promising as a future therapy for lung diseases, there is limited knowledge of how to specifically control UPR pathways that activate both pro-survival adaptive responses and cell death.…”
Section: Targets and Therapeutic Interventions For Insufficient Protementioning
confidence: 98%
“…ER stress develops in airway cells in this model and is exacerbated by viral infection, and the UPR has been associated with the differentiation status of macrophages, and intrinsic ER stress within macrophages also occurs 16, 71, 75, 83, 84, 85, 86…”
Section: Oxidative and Er Stress In Chronic Inflammatory And Mucopurumentioning
confidence: 88%
“…4‐phenylbutyrate (4‐PBA) and tauroursodeoxycholic acid (TUDCA) are chemical chaperones which promote correct folding in the ER that have been used widely in animal models of ER stress. 4‐PBA reduced ER stress, inflammation and fibrosis in the bleomycin model in mice,84 attenuated symptoms of asthma in the house dust mite allergen model in mice90 and also reduced ER stress and autophagy in LPS‐induced acute lung injury 104. Similarly, TUDCA has also been demonstrated to alleviate ER stress and associated pathology in the bleomycin fibrosis model and in asthma models in mice 83, 92.…”
Section: Therapeutic Approaches To Resolve Oxidative and Er Stress Inmentioning
confidence: 97%
“…Recent investigations suggested that ER stress could also be involved (Zhao et al. 2014a,b; Tanaka et al. 2015).…”
Section: Introductionmentioning
confidence: 99%