Phenoxetol in the Treatment of Pyocyanea Infections

Gough, J.; Berry, H.; Still, Bess M.

doi:10.1016/s0140-6736(00)42787-x

Cited by 25 publications

(9 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Berry (1944) found that its activity was greatest against Pseudomonas pyocyanea (aeruginosa) and that there was no loss of activity in the presence of 20% serum. In clinical trials, Gough et al (1944) reported that an aqueous solution of 2-2 % phenoxyethanol was effective for the treatment of burns and superficial wounds infected with Ps. pyocyanea, although Gram-positive organisms were apparently not affected.…”

Section: Discussionmentioning

confidence: 99%

Sensitivity of urine-grown cells of Providencia stuartii to antiseptics.

Thomas¹,

Sykes²,

Stickler³

1978

J Clin Pathol

View full text Add to dashboard Cite

Urine-grown cultures of 23 clinical isolates of Gram-negative bacteria having a range of minimum inhibitory concentration values for chorhexidine were challenged with various concentrations of this antiseptic. The results suggest that cells of Providencia stuartii, in particular, exhibit a considerable degree of resistance to chlorhexidine under these conditions, concentrations of up to 10 000--20 000 microgram/ml of urine being necessary to produce complete loss of viability of such cultures. Of the other two antiseptics tested, phenoxyethanol proved to be the more effective, the recommended use concentration of 2% v/v producing reductions in viable counts of greater than six logarithms in all the strains examined. It is suggested that phenoxyethanol may be a suitable alternative to the cationic agents for use in antiseptic policies for bladder management of urinary tract infections with Providencia stuartii.

show abstract

Section: Discussionmentioning

confidence: 99%

Sensitivity of urine-grown cells of Providencia stuartii to antiseptics.

Thomas¹,

Sykes²,

Stickler³

1978

J Clin Pathol

View full text Add to dashboard Cite

show abstract

“…Die Applikation der unverdünnten Substanz auf die intakte Haut an der Innenseite des Handgelenks wurde ohne Reizung vertragen (k. w. A) (Berry 1944). Auch bei der Wundbehandlung mit einer gesättigten wäßrigen Lösung (2,2 Vol-%) wurde keine Reizwirkung beobachtet (Gough et al 1944). Lediglich in einer Untersuchung zum Sensibilisierungspotential an 3726 Patienten mit Ekzem wurden in 9 Fällen mögli-cherweise irritative Reaktionen verzeichnet (Fuchs et al 1991 (Laborit et al 1961).…”

Section: Wirkung Auf Haut Und Schleimhäuteunclassified

“…Bei Ratten wurde ein sedativer Effekt nach i.p., i.v. oder s.c. Injektion mehrerer Milliliter einer 2,2%igen (Vol-%) wäßrigen Lösung von 2-Phenoxyethanol beobachtet (Gough et al 1944). Die Ergebnisse sind allerdings unzureichend dokumenticrt.…”

Section: Wirkung Auf Haut Und Schleimhäuteunclassified

“…In der Europäischen Gemeinschaft für Kosmetika zugelassen bis max. 1%, in Augentropfen �2% (Anonym 1990b) Weitverbreitetes Lösemittel u. a. für Celluloseacetat, für Farbstoffe, Tinten, Kunstharze, Klebstoffe für Behälter im Lebensmittelbereich, Zwischenprodukt für chemische Synthesen (Anonym 1990b) und in Latexfarben (Breslin et al 1991), Duftstoff in Parfümen (Hall 1984) Insektenschutzmittel (Anonym 1990b), Anästhetikum und Therapeutikum in der Fischzucht (Frølich et al 1984;Jolly et al 1972;Josa et al 1992;Puceat et al 1989;Sehdev et al 1963) In der Medizin als Antiseptikum (Gough et al 1944;Mitchell et al 1993;Stickler et al 1981), als Konservierungsmittel in Anatomie und Taxonomie (Frølich et al 1984;Nakanishi et al 1969;Wineski und English 1989) Besondere Hinweise 2-Phenoxyethanol ist ein Breitspektrum-Mikrobizid mit besonderer Aktivität gegenüber gramnegativen Bakterien wie Pseudomonaden. In höheren Konzentrationen wirkt 2-Phenoxyethanol auch gegen grampositive Bakterien wie Staphylococcus aureus sowie Pilze (Hall 1984).…”

unclassified

See 1 more Smart Citation

2‐Phenoxyethanol [MAK Value Documentation in German language, 1998]

2012

The MAK‐Collection for Occupational Health and Safety

View full text Add to dashboard Cite

Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 26. Lieferung, Ausgabe 1998 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme Metabolismus Verteilung und Ausscheidung Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Sonstiges Bewertung

show abstract

“…The effectiveness of this agent against P. aeruginosa has been known for some time and it appears to be more active against this species than against E. coli and even Gram-positive organisms (Berry, 1944;Gough, Berry and Still, 1944). Thomas et al, (1978) also found that it was bactericidal against urine grown cultures of P. aeruginosa, Proteus mirabilis and Providencia stuartii known to be resistant to be cationic antiseptics.…”

Section: Figmentioning

confidence: 99%

Antiseptic and antibiotic resistance in Gram-negative bacteria causing urinary tract infection in spinal cord injured patients

1981

View full text Add to dashboard Cite

Abstract. Fifty-seven isolates of Gram-negative bacterial species from urinary tract infections in spinal cord injured patients were tested for their sensitivity to chlorhexidine, cetrimide, glutaraldehyde, phenyl mercuric nitrate (PMN), a phenolic disinfectant (Hycolin) and a proprietary antiseptic containing a mixture of picloxydine, octylphenoxy polyethoxyethanol and benzalkonium chloride (Resiguard). None of the isolates were resistant to glutaraldehyde, Hycolin or PMN but a substantial percentage were resistant to chlorhexidine (44 per cent), cetrimide (26 per cent) and Resiguard (42 per cent). The resistant organisms were members of the genera Proteus, Providencia and Pseudomonas and they were also generally resistant to five, six or seven antibiotics. Significant correlations were observed between multiplicity of antibiotic resistance and the minimum inhibitory concentrations of the three cationic antiseptics. It is suggested that an antiseptic policy for the bladder management of spinal cord injured patients that relies on the extensive use of cationic agents might lead to the selection of a flora of notoriously drug-resistant species.

show abstract

Phenoxetol in the Treatment of Pyocyanea Infections

Cited by 25 publications

References 9 publications

Sensitivity of urine-grown cells of Providencia stuartii to antiseptics.

Sensitivity of urine-grown cells of Providencia stuartii to antiseptics.

2‐Phenoxyethanol [MAK Value Documentation in German language, 1998]

Antiseptic and antibiotic resistance in Gram-negative bacteria causing urinary tract infection in spinal cord injured patients

Contact Info

Product

Resources

About