Phenotypic Parameters Predict Time to Normalization in Infants with Hypogammaglobulinemia

Winkle, R.C. Van; McGeady, Stephen J.

doi:10.1007/s10875-013-9937-7

Cited by 9 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One of them, transient hypogammaglobulinaemia of infancy (THI), is a heterogeneous disorder characterised by reduced serum IgG (often IgA and sometimes also IgM) level in early childhood and recurrent infections, mostly of the respiratory tract [24-26]. A putative diagnosis is initially made after exclusion of other causes of hypogammaglobulinaemia, while a definitive diagnosis of THI can only be made retrospectively in patients with normalised IgG levels and withdrawal of clinical symptoms, which occurs usually between the second and fourth year of life [27]. The underlying definitive basis of this disorder is still unknown.…”

Section: Introductionmentioning

confidence: 99%

The level of myeloid-derived suppressor cells positively correlates with regulatory T cells in the blood of children with transient hypogammaglobulinaemia of infancy

Siemińska

Rutkowska-Zapała

Bukowska-Straková

et al. 2018

cejoi

View full text Add to dashboard Cite

IntroductionTransient hypogammaglobulinaemia of infancy (THI) is a primary immunodeficiency characterised by low levels of immunoglobulin G (often with concomitant decrease of IgA and sometimes also of IgM) with still unknown exact reason. A delayed normalisation of the immunoglobulin level in THI may be associated with a transiently elevated number of regulatory T cells (Treg). Although in cancer and chronic inflammation it was shown that the level of Treg cells can be increased by myeloid-derived suppressor cells (MDSCs), until now no studies have been performed in the context of the role of MDSCs in THI and their correlation with Treg cells. Consequently, we aimed to determine the occurrence of MDSCs in the peripheral blood of children with THI and correlate their level with the level of Treg cells.Material and methodsFlow cytometry analyses of Mo-MDSCs and Gr-MDSCs, characterised as HLA-DR–CD11b+CD15–CD14+ and HLA-DR–CD11b+CD15+CD14–, respectively, and Treg (CD4+CD25+Foxp3+) cells were performed.ResultsThe proportion of Mo-MDSCs and Gr-MDSCs was significantly higher in the group of THI patients with elevated level of Treg cells (from the 95% confidence interval level of healthy controls). The cells with Mo-MDSC and Gr-MDSC characteristics positively correlated with the level of Treg cells. Moreover, children with a higher proportion of circulating Treg cells, and thereby higher level of MDSCs, showed delayed normalisation of IgG level and recovery.ConclusionsThese findings show for the first time that MDSCs may be involved in the pathomechanism of THI, probably acting through the induction of Treg cells.

show abstract

Section: Introductionmentioning

confidence: 99%

The level of myeloid-derived suppressor cells positively correlates with regulatory T cells in the blood of children with transient hypogammaglobulinaemia of infancy

Siemińska

Rutkowska-Zapała

Bukowska-Straková

et al. 2018

cejoi

View full text Add to dashboard Cite

show abstract

“…Tekrarlayan enfeksiyon öyküsü bulunan çocuklarda bağışıklığın kontrolü önem taşımaktadır. İmmünoglobulin replasman tedavisinin hangi durumlarda verilmesi gerektiği halen tartışmalıyken, IVIG tedavisinin immünoglobulin değerlerindeki düzelme süresini olumlu etkilediği de bilinmektedir (14). Çalışmamızda antikor eksikliği tanısı alan çocukların retrospektif olarak değerlendirilmiş olması, antikor eksikliğine bağlı immün yetmezlikler alt grup tanı ve tetkikleri merkezimizde analiz edilememiş olması çalışmamızın kısıtlı yanlarıdır.…”

Section: Bulgularunclassified

Antikor eksikliği olan çocukların retrospektif olarak değerlendirilmesi

Altaş¹

2023

Ümraniye Pediatri Dergisi - Journal of Umraniye Pediatrics

View full text Add to dashboard Cite

Objective: In this study, it was aimed to evaluate the clinical features and laboratory parameters of the patients followed in the Pediatric Allergy and Immunology outpatient clinic with the diagnosis of antibody deficiency retrospectively. Material and Methods: Between May 01, 2021 and May 01, 2022, 277 patients followed up in the Pediatric Allergy and Immunology outpatient clinic with the diagnosis of antibody deficiency were included in the study. The medical records of the patients were reviewed; their clinical characteristics, use of intravenous immunoglobulin therapy, frequency of use of antibiotics, and laboratory parameters were evaluated within the scope of the study. Results: Two hundred and seventy-seven patients diagnosed with antibody deficiency were included in our study. About 33.9% (n=94) were female, 66.1% (n=183) were male, and the median age was 21.0 months (1-200 months). Recurrent infections were observed in 39.7% (n=110) of the patients, asthma in 17.0% (n=47), food allergy in 14.1% (n=39), allergic rhinitis in 13.7% (n=38), atopic dermatitis in 12.6% (n=35), and urticaria in 2.9% (n=8). As expected, patients receiving intravenous immunoglobulin therapy had significantly lower baseline serum IgG values (p=0.038). Conclusion:The diagnosis of primary immunodeficiency should be considered in children with frequent infections and atopic clinical findings. These patients should be evaluated with appropriate anamnesis and laboratory tests. Early diagnosis and initiation of appropriate treatment are extremely important in terms of preventing disease-related complications, as in other chronic diseases.

show abstract

“…40 This is called selective IgA deficiency (IGAD). 68,71 High total B cells, low memory B cells and reduced CD19 on B cells have been described in patients with THI. As with CVID, due to rapid immune system development in children and wider normal ranges of immunoglobulin levels in early childhood, it is not appropriate to confer a diagnosis of IGAD below begins.…”

Section: Iga Deficiencymentioning

confidence: 99%

“…Transient hypogammaglobulinemia of infancy (THI) is an IgG deficiency that begins in infancy and resolves spontaneously by 5 years of age. 19,68,69,71 By definition, IgG is lower than normal for age.…”

Section: Iga Deficiencymentioning

confidence: 99%

Antibody Deficiency

Bonilla¹

2016

Pediatric Allergy: Principles and Practice

View full text Add to dashboard Cite

Phenotypic Parameters Predict Time to Normalization in Infants with Hypogammaglobulinemia

Cited by 9 publications

References 11 publications

The level of myeloid-derived suppressor cells positively correlates with regulatory T cells in the blood of children with transient hypogammaglobulinaemia of infancy

The level of myeloid-derived suppressor cells positively correlates with regulatory T cells in the blood of children with transient hypogammaglobulinaemia of infancy

Antikor eksikliği olan çocukların retrospektif olarak değerlendirilmesi

Antibody Deficiency

Contact Info

Product

Resources

About