Antikor eksikliği olan çocukların retrospektif olarak değerlendirilmesi

Abstract

Objective: In this study, it was aimed to evaluate the clinical features and laboratory parameters of the patients followed in the Pediatric Allergy and Immunology outpatient clinic with the diagnosis of antibody deficiency retrospectively. Material and Methods: Between May 01, 2021 and May 01, 2022, 277 patients followed up in the Pediatric Allergy and Immunology outpatient clinic with the diagnosis of antibody deficiency were included in the study. The medical records of the patients were reviewed; their clinical characteristics, use of intravenous immunoglobulin therapy, frequency of use of antibiotics, and laboratory parameters were evaluated within the scope of the study. Results: Two hundred and seventy-seven patients diagnosed with antibody deficiency were included in our study. About 33.9% (n=94) were female, 66.1% (n=183) were male, and the median age was 21.0 months (1-200 months). Recurrent infections were observed in 39.7% (n=110) of the patients, asthma in 17.0% (n=47), food allergy in 14.1% (n=39), allergic rhinitis in 13.7% (n=38), atopic dermatitis in 12.6% (n=35), and urticaria in 2.9% (n=8). As expected, patients receiving intravenous immunoglobulin therapy had significantly lower baseline serum IgG values (p=0.038). Conclusion:The diagnosis of primary immunodeficiency should be considered in children with frequent infections and atopic clinical findings. These patients should be evaluated with appropriate anamnesis and laboratory tests. Early diagnosis and initiation of appropriate treatment are extremely important in terms of preventing disease-related complications, as in other chronic diseases.