Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4+CD25+ regulatory T-lymphocyte response to tobacco smoking

Barceló, Bernardino; Pons, Jaume; Ferrer, J.M. Escribano; Sauleda, Jaume; Fuster, Antònia; Agustí, Àlvar

doi:10.1183/09031936.00010407

Cited by 169 publications

(163 citation statements)

References 32 publications

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“…Previous studies have characterised T-regulatory cells from bronchoalveolar lavage fluid (BALF), dispersed lung cells and peripheral blood [6,13,14]. The major finding was that CD4 +…”

Section: This Is the First Study To Quantify And Describe The Localismentioning

confidence: 94%

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Increased T-regulatory cells within lymphocyte follicles in moderate COPD

Plumb¹,

Smyth²,

Adams³

et al. 2009

European Respiratory Journal

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Lymphoid follicles in the lung parenchyma are a characteristic feature of chronic obstructive pulmonary disease (COPD). There are reports of altered CD4 T-regulatory cell numbers in COPD lungs, but the location of these cells within COPD lung tissue specific follicles has not been investigated.The presence of CD4 + FOXP3 + T-regulatory cells was assessed in surgically resected lung tissue from 12 COPD patients, 11 smokers with normal lung function and seven nonsmokers by combined immunofluorescence and immunohistochemistry. Organised lymphoid follicles were observed in all three groups of patients, as well as lymphoid clusters lacking organisation. The percentage of CD4 cells that were T-regulatory cells were significantly increased (p50.02) within COPD (16%) follicles compared with smokers (10%) and nonsmokers (8%). In contrast, there was no change (p.0.05) in the percentage of T-regulatory cells in clusters or the subepithelium between groups.Lymphoid follicles in COPD patients have increased T-regulatory cells. Therefore, T-regulatory activity may be altered within COPD lymphoid follicles.

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“…Previous studies have characterised T-regulatory cells from bronchoalveolar lavage fluid (BALF), dispersed lung cells and peripheral blood [6,13,14]. The major finding was that CD4 +…”

Section: This Is the First Study To Quantify And Describe The Localismentioning

confidence: 94%

“…T-regulatory markers including FOXP3 have been used to show that smokers have increased numbers of T-regulatory cells in bronchoalveolar lavage fluid [13,14] compared with nonsmokers. One of these studies also showed decreased Tregulatory numbers in COPD patients compared to smokers with normal lung function, suggesting decreased T-regulatory function in COPD.…”

mentioning

confidence: 99%

Increased T-regulatory cells within lymphocyte follicles in moderate COPD

Plumb¹,

Smyth²,

Adams³

et al. 2009

European Respiratory Journal

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“…IL-2, which plays a critical role in the development and homeostasis of Treg cells, 39 is elevated in COPD patients who show disease stability, 40 inducing dominant upregulation of Treg cells in smokers with preserved lung function compared with COPD patients. 41 As our previous studies demonstrated that sγc inhibits IL-2 signaling, 22 excessive T cell response with IL-2-induced Treg cells. On the other hand, Treg development depends on IL-2 and TGFβ, which is also linked to Th17 differentiation.…”

Section: Discussionmentioning

confidence: 99%

Soluble common gamma chain exacerbates COPD progress through the regulation of inflammatory T cell response in mice

Lee

et al. 2017

COPD

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Cigarette smoking (CS) is a major cause of considerable morbidity and mortality by inducing lung cancer and COPD. COPD, a smoking-related disorder, is closely related to the alteration of immune system and inflammatory processes that are specifically mediated by T cells. Soluble common gamma chain (sγc) has recently been identified as a critical regulator of the development and differentiation of T cells. We examined the effects of sγc in a cigarette smoke extract (CSE) mouse model. The sγc level in CSE mice serum is significantly downregulated, and the cellularity of lymph node (LN) is systemically reduced in the CSE group. Overexpression of sγc enhances the cellularity and IFNγ production of CD8 T cells in LN and also enhances Th1 and Th17 differentiation of CD4 T cells in the respiratory tract. Mechanistically, the downregulation of sγc expression mediated by CSE is required to prevent excessive inflammatory T cell responses. Therefore, our data suggest that sγc may be one of the target molecules for the control of immunopathogenic progresses in COPD.

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“…CD8+ T-cells were mature cells characterised by a high CD45RA/CD45R0 ratio. Compared with never-smokers, smokers with normal lung function showed a prominent upregulation of T-regulatory cells that was absent in patients with COPD [73]. Recruitment of CD8+ T lymphocytes may be triggered chemokines secreted by the epithelium of small conducting airways.…”

Section: Distal Airways Inflammation In Copdmentioning

confidence: 99%

Update on the roles of distal airways in COPD

Burgel

Bourdin²,

Chanez³

et al. 2011

European Respiratory Review

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This review is the summary of a workshop on the role of distal airways in chronic obstructive pulmonary disease (COPD), which took place in 2009 in Vence, France.The evidence showing inflammation and remodelling in distal airways and the possible involvement of these in the pathobiology, physiology, clinical manifestations and natural history of COPD were examined. The usefulness and limitations of physiological tests and imaging techniques for assessing distal airways abnormalities were evaluated.Ex vivo studies in isolated lungs and invasive measurements of airway resistance in living individuals have revealed that distal airways represent the main site of airflow limitation in COPD. Structural changes in small conducting airways, including increased wall thickness and obstruction by muco-inflammatory exudates, and emphysema (resulting in premature airway closure), were important determinants of airflow limitation. Infiltration of small conducting airways by phagocytes (macrophages and neutrophils), dendritic cells and T and B lymphocytes increased with airflow limitation. Distal airways abnormalities were associated with patient-related outcomes (e.g. dyspnoea and reduced health-related quality of life) and with the natural history of the disease, as reflected by lung function decline and mortality.These data provide a clear rationale for targeting distal airways in COPD.

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Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4+CD25+ regulatory T-lymphocyte response to tobacco smoking

Cited by 169 publications

References 32 publications

Increased T-regulatory cells within lymphocyte follicles in moderate COPD

Increased T-regulatory cells within lymphocyte follicles in moderate COPD

Soluble common gamma chain exacerbates COPD progress through the regulation of inflammatory T cell response in mice

Update on the roles of distal airways in COPD

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