Increased T-regulatory cells within lymphocyte follicles in moderate COPD

Plumb, Jonathan; Smyth, Lesley A.; Adams, H. R.; Vestbo, Jørgen; Bentley, Andrew; Singh, Sangya

doi:10.1183/09031936.00100708

Cited by 65 publications

(65 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…By contrast, although previous data of PLUMB et al [5] indicated an increase in CD4 + T-cells in parenchymal LFs of moderate COPD patients, the present results do not show any significant difference in the follicular densities of B-cells, T-cells, macrophages or mature dendritic cells among clinical groups.…”

Section: Discussioncontrasting

confidence: 56%

“…We have stated that LFs were located in both the adventitia of airways and the parenchyma of pulmonary samples, as previously described [2][3][4][5][6]14]. However, the presence of LFs was also observed in the connective tissue of lobular septa and in the arteriolar adventitia, the later compartment being the most frequently occupied by LFs in COPD patients.…”

Section: Discussionmentioning

confidence: 69%

“…For a long time, the presence of LFs has been associated with COPD progression [3], but only recently has some attention been paid to the study of the cellular and molecular patterns of this tertiary lymphoid tissue in COPD patients [5,6]. Following this research line, the present work represents a complete study of LFs, including their prevalence, vascularisation, cell composition and proliferation/apoptosis in patients with moderate and very severe COPD.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, only one study reported a higher percentage of T-regulatory cells within LFs of moderate COPD patients compared with smokers and nonsmokers [5], but no information is available regarding vascular supply, lymphatic drainage or the follicular densities of other key inflammatory cells in subjects with and without COPD. Moreover, there are no studies examining which addressins are involved in the migration of inflammatory cells from the blood into the LFs in COPD.…”

mentioning

confidence: 99%

“…Recently, this inflammatory process has been associated with the development of ectopic lymphoid follicles (LFs) in lungs of COPD patients [2][3][4][5][6][7], which are similar to the tertiary lymphoid tissue found in other inflammatory or autoimmune diseases [8,9].…”

mentioning

confidence: 99%

See 4 more Smart Citations

Significant increase of CD57+ cells in pulmonary lymphoid follicles of COPD patients

Olloquequi¹,

Montés²,

Prats³

et al. 2010

European Respiratory Journal

View full text Add to dashboard Cite

Although the presence of pulmonary lymphoid follicles (LFs) has been associated with the progression of chronic obstructive pulmonary disease (COPD), there is no information regarding the pattern of vascularisation, expression of addressins or inflammatory cell densities within these structures in COPD.Histological and immunohistochemical techniques were used to assess the prevalence, structure, localisation, vascularisation and cell proliferation/apoptosis of LFs, as well as the follicular density of B-and T-lymphocytes, macrophages, dendritic cells and CD57+ cells, in lung tissue of nine nonsmokers, 18 smokers without COPD, 16 smokers with moderate COPD and 16 patients with very severe COPD. The density of CD57 + cells within LFs of COPD patients was significantly increased compared to that of nonsmokers and smokers without COPD (p,0.05). Moreover, the percentage of LF profiles with cell apoptosis was also significantly higher in COPD patients (p50.03). By contrast, no significant differences among groups were observed in the follicular densities of other inflammatory cells, nor in the distribution of blood and lymphatic vessels within LFs. Since CD57 + cells are important effectors of cytotoxicity and immune regulation, an increase in their follicular density supports the hypothesis of local immune dysfunction in COPD.

show abstract

Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Significant increase of CD57+ cells in pulmonary lymphoid follicles of COPD patients

Olloquequi¹,

Montés²,

Prats³

et al. 2010

European Respiratory Journal

View full text Add to dashboard Cite

show abstract

Combined Pulmonary Fibrosis and Emphysema in Scleroderma‐Related Lung Disease Has a Major Confounding Effect on Lung Physiology and Screening for Pulmonary Hypertension

Αντωνίου

Margaritopoulos

Goh

et al. 2016

Arthritis & Rheumatology

View full text Add to dashboard Cite

Objective. To assess the prevalence of combined pulmonary fibrosis and emphysema (CPFE) in systemic sclerosis (SSc) patients with interstitial lung disease (ILD) and the effect of CPFE on the pulmonary function tests used to evaluate the severity of SSc-related ILD and the likelihood of pulmonary hypertension (PH).Methods. High-resolution computed tomography (HRCT) scans were obtained in 333 patients with SScrelated ILD and were evaluated for the presence of emphysema and the extent of ILD. The effects of emphysema on the associations between pulmonary function variables and the extent of SSc-related ILD as visualized on HRCT and echocardiographic evidence of PH were quantified.Results. Emphysema was present in 41 (12.3%) of the 333 patients with SSc-related ILD, in 26 (19.7%) of 132 smokers, and in 15 (7.5%) of 201 lifelong nonsmokers. When the extent of fibrosis was taken into account, emphysema was associated with significant additional differences from the expected values for diffusing capacity for carbon monoxide (DLCO) (average reduction of 24.1%; P < 0.0005), and the forced vital capacity (FVC)/DLCO ratio (average increase of 34.8%; P < 0.0005) but not FVC. These effects were identical in smokers and nonsmokers. Multivariate analysis showed that the presence of emphysema had a greater effect than echocardiographically determined PH on the FVC/DLCO ratio, regardless of whether it was analyzed as a continuous variable or using a threshold value of 1.6 or 2.0.Conclusion. Among patients with SSc-related ILD, emphysema is sporadically present in nonsmokers and is associated with a low pack-year history in smokers. The confounding effect of CPFE on measures of gas exchange has major implications for the construction of screening algorithms for PH in patients with SSc-related ILD.Pulmonary involvement (including interstitial lung disease [ILD] and pulmonary hypertension [PH]) is the most common cause of death among patients with

show abstract

Role of Th17 cells, Treg cells, and Th17/Treg imbalance in immune homeostasis disorders in patients with chronic obstructive pulmonary disease

Jiao

et al. 2023

Immunity Inflam & Disease

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, following strokes and cardiovascular diseases. Chronic lung inflammation is believed to play a role in the development of COPD. In addition, accumulating evidence shows that the immune system plays a crucial role in the pathogenesis of COPD. Significant advancements have been made in research on the pathogenesis of immune diseases and chronic inflammation in recent years, and T helper 17 (Th17) cells and regulatory T (Treg) cells have been found to play a crucial role in the autoimmune response. Th17 cells are a proinflammatory subpopulation that causes autoimmune disease and tissue damage. Treg cells, on the other hand, have a negative effect but can contribute to the occurrence of the same disease when their antagonism fails. This review mainly summarizes the biological characteristics of Th17 cells and Treg cells, their roles in chronic inflammatory diseases of COPD, and the role of the Th17/Treg ratio in the onset, development, and outcome of inflammatory disorders, as well as recent advancements in immunomodulatory treatment targeting Th17/Treg cells in COPD.

show abstract

Increased T-regulatory cells within lymphocyte follicles in moderate COPD

Cited by 65 publications

References 27 publications

Significant increase of CD57+ cells in pulmonary lymphoid follicles of COPD patients

Significant increase of CD57+ cells in pulmonary lymphoid follicles of COPD patients

Combined Pulmonary Fibrosis and Emphysema in Scleroderma‐Related Lung Disease Has a Major Confounding Effect on Lung Physiology and Screening for Pulmonary Hypertension

Role of Th17 cells, Treg cells, and Th17/Treg imbalance in immune homeostasis disorders in patients with chronic obstructive pulmonary disease

Contact Info

Product

Resources

About