Phenotypic and genetic structure of anxiety sensitivity in adolescence and early adulthood

Brown, Hannah Mary; Trzaskowski, Maciej; Zavos, Helena; Rijsdijk, Frühling; Gregory, Alice M.; Eley, Thalia C.

doi:10.1016/j.janxdis.2012.05.001

Cited by 21 publications

(21 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…'I don't like to let my feelings show'), seems to be associated with both anxiety and depression (Dehon et al 2005), although others show stronger association with anxiety symptoms (Taylor et al 1996;Schmidt et al 1998). Although there is debate regarding the specific number and content of anxiety sensitivity subscales, confirmatory factor analytic studies (Wright et al 2010) and a twin study by our group (Brown et al 2012) support a hierarchical structure of anxiety sensitivity with three dimensions representing physical, social and mental concerns.…”

Section: Anxiety Sensitivity: Subscale Analysesmentioning

confidence: 92%

Cognitive content specificity in anxiety and depressive disorder symptoms: a twin study of cross-sectional associations with anxiety sensitivity dimensions across development

et al. 2014

Self Cite

View full text Add to dashboard Cite

Phenotypic patterns of cognitive specificity and broader genetic associations between anxiety sensitivity dimensions, anxiety and depressive disorder symptoms were similar at all waves. Both disorder-specific and shared cognitive concerns were identified, suggesting it is appropriate to classify anxiety and depression as distinct but related disorders and confirming the clinical perspective that cognitive therapy is most likely to benefit by targeting cognitive concerns relating specifically to the individual's presenting symptoms across development.

show abstract

Section: Anxiety Sensitivity: Subscale Analysesmentioning

confidence: 92%

Cognitive content specificity in anxiety and depressive disorder symptoms: a twin study of cross-sectional associations with anxiety sensitivity dimensions across development

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…The ASI is comprised of 16 items rated on agreement with statements of fear of anxiety-related sensations or symptoms (e.g., “it scares me when I am nauseous”). Applicability of the ASI to adolescent samples has been routinely demonstrated (H. M. Brown et al, 2012; Silverman, Goedhart, Barrett, & Turner, 2003). Inter-item and test-retest reliability have previously been established (Peterson & Reiss, 1992).…”

Section: Methodsmentioning

confidence: 99%

Clinical characteristics of latent classes of CO 2 hypersensitivity in adolescents and young adults

Rappaport

Sheerin

Savage

et al. 2017

Behaviour Research and Therapy

View full text Add to dashboard Cite

Although breathing CO2-enriched air reliably increases anxiety, there is debate concerning the nature and specificity of CO2 hypersensitivity to panic risk and panic disorder versus anxiety disorders and related traits broadly, particularly among adolescents and emerging adults. The present study sought to clarify the association of CO2 hypersensitivity with internalizing conditions and symptoms among adolescents and young adults. Participants (N = 628) self-reported anxiety levels every 2 minutes while breathing air enriched to 7.5% CO2 for 8 minutes. Growth mixture models were used to examine the structure of anxiety trajectories during the task and the association of each trajectory with dimensional and diagnostic assessments of internalizing disorders. Three distinct trajectories emerged: overall low (low), overall high (high), and acutely increased anxiety (acute). Compared to the low class, the acute class reported elevated neuroticism, anxiety sensitivity, stress whereas the high class reported elevated anxiety symptoms, depression symptoms, neuroticism, anxiety sensitivity, and increased likelihood of an anxiety disorder diagnosis. Moreover, the acute and high classes reported experiencing a panic-like event at a higher rate than the low class while participants in the high class terminated the task prematurely at a higher rate. The present study clarifies the nature of response to CO2 challenge. Three distinct response profiles emerged, which clarifies the manifestation of CO2 hypersensitivity in anxiety disorders with strong, though not unique, associations with panic-relevant traits.

show abstract

“…Zinbarg et al [50] have provided results demonstrating that anxiety-sensitivity-Physical Concerns is the only one of the three anxiety-sensitivity group factors that contributes to relations with fear responses, whereas anxiety-sensitivity-Mental Incapacitation Concerns produced a stronger positive linear association with depressed mood than did anxiety-sensitivity-Physical Concerns. In a self-report study of three test-time points from adolescence to young adulthood with 2651 participants from the G1219 twin study, Brown et al [51] also obtained a three-factor model that depicted the Physical, Social, and Mental anxiety-related incapacitation concerns. However, the findings were characterized by higher levels of interpretability and parsimony than previously reported.…”

Section: Mood Disorders Genes Pathophysiology and Environmentmentioning

confidence: 99%

Epigenetic Modulation of Mood Disorders

Archer

Blum²,

Ms³

2013

J Genet Syndr Gene Ther

View full text Add to dashboard Cite

Background Mood disorders are expressed in many heterogeneous forms, varying from anxiety to severe major clinical depression. The disorders are expressed in individual variety through manifestations governed by co-morbidities, symptom frequency, severity, and duration, and the effects of genes on phenotypes. The underlying etiologies of mood disorders consist of complex interactive operations of genetic and environmental factors. The notion of endophenotypes, which encompasses the markers of several underlying liabilities to the disorders, may facilitate efforts to detect and define, through staging, the genetic risks inherent to the extreme complexity of disease state. Aims This review evaluates the role of genetic biomarkers in assisting clinical diagnosis, identification of risk factors, and treatment of mood disorders. Methods Through a systematic assessment of studies investigating the epigenetic basis for mood disorders, the present review examines the interaction of genes and environment underlying the pathophysiology of these disorders. Results The majority of research findings suggest that the notion of endophenotypes, which encompasses the markers of several underlying liabilities to the disorders, may facilitate efforts to detect and define, through staging, the genetic risks inherent to the extreme complexity of the disease states. Several strategies under development and refinement show the propensity for derivation of essential elements in the etiopathogenesis of the disorders affecting drug-efficacy, drug metabolism, and drug adverse effects, e.g., with regard to selective serotonin reuptake inhibitors. These include: transporter gene expression and genes encoding receptor systems, hypothalamic-pituitary-adrenal axis factors, neurotrophic factors, and inflammatory factors affecting neuroimmune function. Nevertheless, procedural considerations of pharmacogenetics presume the parallel investment of policies and regulations to withstand eventual attempts at misuse, thereby ensuring patient integrity. Conclusions Identification of genetic biomarkers facilitates choice of treatment, prediction of response, and prognosis of outcome over a wide spectrum of symptoms associated with affective states, thereby optimizing clinical practice procedures. Epigenetic regulation of primary brain signaling, e.g., serotonin and hypothalamic-pituitary-adrenal function, and factors governing their metabolism are necessary considerations. The participation of neurotrophic factors remains indispensable for neurogenesis, survival, and functional maintenance of brain systems.

show abstract

Phenotypic and genetic structure of anxiety sensitivity in adolescence and early adulthood

Cited by 21 publications

References 34 publications

Cognitive content specificity in anxiety and depressive disorder symptoms: a twin study of cross-sectional associations with anxiety sensitivity dimensions across development

Cognitive content specificity in anxiety and depressive disorder symptoms: a twin study of cross-sectional associations with anxiety sensitivity dimensions across development

Clinical characteristics of latent classes of CO 2 hypersensitivity in adolescents and young adults

Epigenetic Modulation of Mood Disorders

Contact Info

Product

Resources

About