Phenotypes and Endotypes of Occupational Chronic  Obstructive Pulmonary Disease Caused by Toxic Gas  or Inorganic Dust

Shpagina, L. A.; Kotova, Olga; Герасименко, О Н; SHPAGIN, ILIA S.; Суровенко, Т. Н.; Karmanovskaya, S. A.; Ermakova, M A

doi:10.20969/vskm.2017.10(5).56-65

BCCM

2017

DOI: 10.20969/vskm.2017.10(5).56-65

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Phenotypes and Endotypes of Occupational Chronic Obstructive Pulmonary Disease Caused by Toxic Gas or Inorganic Dust

L. A. Shpagina¹,

Olga Kotova²,

О Н Герасименко³

et al.

Abstract: ШПАГИНА ЛЮБОВЬ АНАТОЛЬЕВНА, докт. мед. наук, профессор, зав. кафедрой госпитальной терапии и медицинской реабилитации ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России, Россия, 630084, Новосибирск, ул. Ползунова, 21, тел. +7(383) 279-99-45, e-mail: mkb-2@yandex.ru КОТОВА ОЛЬГА СЕРГЕЕВНА, канд. мед. наук, доцент кафедры госпитальной терапии и медицинской реабилитации ФГБОУ ВО «Новосибирский государственный медицинский университет » Минздрава России, Россия, 630084, Новосибирск,… Show more

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Epidemiological features of occupational chronic obstructive lung disease

Сакольчик¹,

Gorblyansky²,

Podmogilnaya³

et al. 2018

Myditsina truda I promyshlennaya ekologiy

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Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality all over the world. Tobacco smoking is a main risk factor, but nearly 15–20% of COPD cases are caused by occupational exposure (to dust, gases, vapors, fibers). The review is aimed to search and analysis of literature on occupational COPD from evidencebased medicine viewpoint. Systemic search of literature covered databases of PubMed, Google Scholar, Cyberleninka, using a key word “occupational COPD”. As a result of the search, the authors selected 6 systematic reviews and 9 clinical studies for further analysis, proved cause-effect relationship between exposure to occupational factors at workplace and COPD. With that, occupational exposure contributes more significantly into formation and peculiarities of COPD course, than tobacco smoking does. Topics of phenotyping, early diagnosis, treatment peculiarities and pulmonary rehabilitation for occupational COPD patients remain unresolved.

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Epidemiological features of occupational chronic obstructive lung disease

Сакольчик¹,

Gorblyansky²,

Podmogilnaya³

et al. 2018

Myditsina truda I promyshlennaya ekologiy

View full text Add to dashboard Cite

show abstract

Diagnosing disorders of respiratory mechanics in refractory workers

Obukhova,

Omelchenko,

Budkar

et al. 2023

Hygiene and Sanitation

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Introduction. The current decrease in occupational exposures complicates expert examination of the link between job and disease, thus requiring the use of more sensitive and high-tech diagnostic techniques. In addition, a low incidence rate of occupational diseases against the background of poor working conditions indicates a possible increase in the incidence of “hidden” occupational diseases mimicking common non-communicable diseases. The purpose of our study was to assess the respiratory function in refractory workers using body plethysmography and measurements of the diffusing capacity of the lungs. Materials and methods: One hundred six male workers aged of 45.62±0.8 years, all engaged in refractory manufacturing for the average of 15.5±0.88 years and at risk of dust-related respiratory diseases, were examined in our Occupational Health Center within the regular health check-up. Results. The results of body plethysmography (a pulmonary function test) showed a decrease in the FEV1/FVC ratio, i.e. the ratio of the forced expiratory volume over the first one second to the forced vital capacity of the lungs, to the group average of 77.87±0.76% of the normal value. We also observed increased bronchial resistance during exhalation and total bronchial resistance in 65% and 50.9% of the workers, respectively. We registered a decreased transfer factor in the examined subjects with the group average of 73.9±1.37%. Neither chest X-ray nor CT scan showed significant changes in most of workers. Signs of emphysema were registered in 5.7% of those examined cases. No significant differences in the prevalence of obstructive disorders were found between smoking and non-smoking workers. Bronchial obstructive syndrome in combination with impaired pulmonary gas exchange and respiratory muscle fatigue was registered in 16 workers (15%), thus necessitating specific therapy to interfere with disease progression. Limitations. Our findings cannot be extrapolated to the workforce as a whole, since only men included in the study cohort. Conclusions. Indicators of the diffusing capacity of the lungs, which simultaneously reflect both pulmonary ventilation and perfusion, in combination with findings of body plethysmography and chest CT scan, can provide important information about functional changes in the respiratory system. Early diagnosis of bronchial obstructive syndrome allows timely beginning therapy and prevention of disease progression.

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Phenotypes and Endotypes of Occupational Chronic Obstructive Pulmonary Disease Caused by Toxic Gas or Inorganic Dust

Cited by 2 publications

References 0 publications

Epidemiological features of occupational chronic obstructive lung disease

Epidemiological features of occupational chronic obstructive lung disease

Diagnosing disorders of respiratory mechanics in refractory workers

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