Phenotypes and concentration of PON1 in cardiovascular disease: The role of nutrient intake

Ponce-Ruíz, N.; Murillo-González, F.E.; Rojas-García, Aurora Elizabeth; Hernández, Y.Y. Bernal; Mackness, Mike; Ponce-Gallegos, J.; Barrón-Vivanco, Briscia Socorro; Hernández‐Ochoa, Isabel; González-Arias, Cyndia Azucena; Cervantes, Laura Ortega; Cardoso-Saldaña, Guillermo; Medina-Díaz, Irma Martha

doi:10.1016/j.numecd.2019.08.013

Cited by 14 publications

(11 citation statements)

References 42 publications

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“…Furthermore, the multiple regression model indicated that carbohydrate intake had a small contribution to serum PON1 activity in these CVD patients. One study found association between serum PON1 activity and carbohydrate intake, but just in subjects with cardiovascular risk factors, with no association in CVD group (45). Total carbohydrate intake was inversely associated with HDL cholesterol concentrations (44), which could in turn affect negatively PON1 activity as we observed in this work.…”

Section: Paraoxonase 1 In Cardiovascular Diseasesupporting

confidence: 52%

Factors associated to serum paraoxonase 1 activity in patients with cardiovascular disease

Longo¹,

Veiga²,

Cousen³

et al. 2021

Archives of Endocrinology and Metabolism

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Section: Paraoxonase 1 In Cardiovascular Diseasesupporting

confidence: 52%

Factors associated to serum paraoxonase 1 activity in patients with cardiovascular disease

Longo¹,

Veiga²,

Cousen³

et al. 2021

Archives of Endocrinology and Metabolism

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“…6 In its coding region, there are two common polymorphisms at positions 55 and 192 which is more widely recognized than 55. 7,8 The differences between them are related to their affinity and catalytic activities toward many substrates. 7,8 The Q192R polymorphism or the missense mutation at position 192 (rs662) in exon 6 of the PON1 gene is one of the most important widely studied polymorphisms which involve the substitution of amino acid glutamine (Q) to arginine (R) at position 192 (Q192R).…”

Section: Introductionmentioning

confidence: 99%

“…7,8 The differences between them are related to their affinity and catalytic activities toward many substrates. 7,8 The Q192R polymorphism or the missense mutation at position 192 (rs662) in exon 6 of the PON1 gene is one of the most important widely studied polymorphisms which involve the substitution of amino acid glutamine (Q) to arginine (R) at position 192 (Q192R). 9 A substitution that has the effect of altering catalytic efficiency.…”

Section: Introductionmentioning

confidence: 99%

“…9 A substitution that has the effect of altering catalytic efficiency. 8 In L55M polymorphism, the codon change from TTG to ATG in exon 3 of PON1 gene results in the substitution of amino acid leucine to methionine at position 55. 10 However, the association between PON1 polymorphisms (Q192R and L55M) and NS is not yet fully understood, particularly, in Iraqi patients with NS.…”

Section: Introductionmentioning

confidence: 99%

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The association between PON1 gene polymorphisms (Q192R and L55M) and nephrotic syndrome in Iraqi children

Ali

Baban

Ali

2021

Baghdad J. Biochem. Appl. Biol. Sci.

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Background: The role of paraoxonase 1 enzyme (PON1) and its single nucleotide polymorphisms (SNPs) in children with nephrotic syndrome (NS) has been reported previously in different ethnic and racial groups with divergent results. The human PON1 gene contains two coding region polymorphisms leading to two different PON1 isoforms. Objectives: The aim of the present study was to find out the association between the PON1 (Q192R and L55M) polymorphisms and their relation with serum PON1 activity as well as lipid profile tests (total cholesterol, TC; triglycerides, TG; high-density lipoprotein cholesterol, HDL-c; and low-density lipoprotein cholesterol, LDL-c) in children with NS. Methods: This study included a total of 80 participants (40 with NS in the age group of 2-14 years and 40 age and sex-matched healthy controls). The PON1 enzyme activity and lipid profile tests were measured in serum samples of all included participants. The PON1 genotype was determined by PCR-restriction enzyme fragment length polymorphism (PCR-RFLP) for both PON1 alleles (192 and 55) SNPs. Results: Our findings showed that the mean levels of lipid profile tests (TC, TG, LDL-c) were significantly increased in patients when compared with healthy controls (p<0.05), while the HDL-c concentration was significantly decreased in patients than that of controls. Also, the patients had significantly lower concentrations of PON1 when compared with the controls regardless of the genotype Q192R and L55M polymorphisms. Moreover, the homozygous RR genotype for PON1 SNP 192 and MM homozygous genotype for PON1 SNP 55 were significantly frequent in patients when compared with the controls. Conclusions: Our results support that the presence of the homozygous RR genotype for PON1 SNP 192 and MM homozygous genotype for PON1 SNP 55 were significantly higher in patients compared with the controls.

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“…one of the environmental factors affecting the expression of the PON1 enzyme since malnutrition or healthy foods can change the expression of PON1 (12). Furthermore, fruits could be used to mitigate oxidative stress due to having a high amount of antioxidant agents and thus can increase the activity and mRNA expression of PON1 (13).…”

mentioning

confidence: 99%

Kiwifruit Supplementation Increases the Activity of the Paraoxonase Enzyme and decreases Oxidized Low-Density Lipoprotein in High-Fat Diet Fed Hamsters

Rezaei

Zaherijamil

Moradkhani

et al. 2020

Avicenna J Med Biochem

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Background: It is shown that kiwifruit elevates serum high-density lipoprotein cholesterol (HDL-C) levels and exhibits beneficial effects on human health due to its antioxidant potential. Objectives: This study aimed to investigate the impact of kiwifruit on the activity of the paraoxonase 1 (PON1) enzyme, as a main antioxidant enzyme in HDL functionality, in a high-fat diet (HFD). Methods: To this end, 42 male Syrian hamsters were divided into 6 groups including hamsters receiving a normal diet (the control normal group), a regular diet supplemented with kiwifruit at two concentrations (i.e., 1.86 g/kg and 3.73 g/kg), a HFD comprised of 15% butterfat + 0.05% cholesterol (the control high-fat group), and a HFD supplemented with kiwifruit at two concentrations (i.e., 1.86 and 3.73 g/kg) for 8 weeks. Results: The results showed that supplementation of kiwifruit to the HFD increased the levels of HDL-C and remarkably reduced the concentrations of oxidized low-density lipoprotein (ox-LDL) and malondialdehyde (MDA) compared with the control-HF group. In addition, the paraoxonase activity of PON1 significantly increased in HFD supplemented with kiwifruit (1.86 g/kg), and finally, arylesterase (ARE) activity increased in all treated groups when compared with untreated groups. Conclusion: Our findings suggested that kiwifruit can improve the lipid profile and prevent oxidative stress-induced by lipid peroxidation in hamsters receiving HFD, thus increasing the ARE and paraoxonase activities of PON1.

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Phenotypes and concentration of PON1 in cardiovascular disease: The role of nutrient intake

Cited by 14 publications

References 42 publications

Factors associated to serum paraoxonase 1 activity in patients with cardiovascular disease

Factors associated to serum paraoxonase 1 activity in patients with cardiovascular disease

The association between PON1 gene polymorphisms (Q192R and L55M) and nephrotic syndrome in Iraqi children

Kiwifruit Supplementation Increases the Activity of the Paraoxonase Enzyme and decreases Oxidized Low-Density Lipoprotein in High-Fat Diet Fed Hamsters

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