Phenothiazine Toxicosis

Hebden, S. P.; Setchell, B. P.

doi:10.1111/j.1751-0813.1962.tb04120.x

Cited by 5 publications

(3 citation statements)

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“…This work also showed that Trichuris ovis was quite susceptible. Hebden and Hall (1965) confirmed that this compound at 50 mg/kg had high activity against mature and immature H . contortus and mature Ostertagia spp and Trichostrongylus spp, but in these trials activity against Nematodirus was lower and somewhat erratic.…”

Section: Naphthalophosssupporting

confidence: 54%

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Recent Advaces in Anthelmintics

Arundel

1967

Aust Veterinary J

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Section: Naphthalophosssupporting

confidence: 54%

“…In small toxicity trials by Smith and Thomas (1964) and Hebden and Hall (1965) an adequate safety margin appeared to exist. However, it is common experience for sheep given normal doses to show diarrhoea, which may persist for 2-3 days.…”

Section: Naphthalophossmentioning

confidence: 96%

Recent Advaces in Anthelmintics

Arundel

1967

Aust Veterinary J

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“…The present study and the report\ of side-resistance i n other Osrerragia in the present study was considered too low for parasite control. I t remains to he determined, however, if the dose rate o f 50 mg kg-1, shown to be highly efficient against Ostertagia by Hebden and Hall (1965) and Train et al (1968), would be efficient against SR80 Osterfagia.…”

Section: Discussionmentioning

confidence: 99%

Resistance to benzimidazole anthelmintics in field strains of Ostertagia and Nematodirus in sheep

1985

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Resistance to a range of benzimidazole anthelmintics was investigated in 2 strains of Ostertagia spp. One strain (SR80) had been exposed to fenbendazole, oxfendazole and thiabendazole, the other strain (KR79) only to thiabendazole. Both strains showed a high degree of resistance to albendazole, fenbendazole, oxfendazole and thiabendazole, which had efficiencies of 11-38% and 0-60% against all developmental stages of SR80 and KR79, respectively. There was no significant reduction in the KR79 worm count by thiabendazole at 132 mg kg-1 given either as a single dose or divided into 12 equal portions, one administered every 6h. Nematodirus spp were also found to be resistant to all benzimidazoles tested. Levamisole at 7 mg kg-1 and naphthalophos at 30 mg kg-1 had efficiences of 89 and 66%, respectively, against SR80 Ostertagia and 99 and 19% against Nematodirus, all but the last of these being significant reductions in worm burdens. The resistant SR80 Ostertagia occurred on a research station, but possibly originated from a property which 3 years earlier had supplied ewes to the station. The use of benzimidazole anthelmintics and subsequent grazing on worm-free pasture may have enhanced the level of resistance. A relationship was established between egg counts and adult worm counts 10 days post-treatment, which suggested that for Ostertagia the worm count could be predicted from the geometric mean egg count from about 10 animals. Thus, where an Ostertagia population is suspected of being resistant, an anthelmintic efficiency assay using pre- and post-treatment faecal egg counts should provide a satisfactory diagnostic procedure.

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A Review of Recent Trends in Animal Poisoning

Humphreys

1978

British Veterinary Journal

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Phenothiazine Toxicosis

Cited by 5 publications

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Recent Advaces in Anthelmintics

Recent Advaces in Anthelmintics

Resistance to benzimidazole anthelmintics in field strains of Ostertagia and Nematodirus in sheep

A Review of Recent Trends in Animal Poisoning

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