Phenomenology and Functioning in First-Episode Schizophrenia

Shtasel, Derri; Gur, Raquel E.; Gallacher, Fiona; Heimberg, Carolyn; Cannon, Tyrone D.; Gur, Ruben C.

doi:10.1093/schbul/18.3.449

Cited by 99 publications

(63 citation statements)

References 41 publications

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“…No sex differences were found for either neuropsychological or clinical change in this sample, although sex differences in the severity and course of schizophrenia have been documented (Shtasel et al, 1992a). This negative finding may reflect sample size.…”

Section: Discussioncontrasting

confidence: 54%

See 1 more Smart Citation

Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia: a longitudinal study

Censits

Ragland

Gur

et al. 1997

Schizophrenia Research

255

142

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The stability of neuropsychological performance in schizophrenia and its relationship to clinical change was contrasted between 60 patients with schizophrenia (30 first-episode, 30 previously treated) and 38 healthy controls using a comprehensive neuropsychological battery and clinical scales administered at intake and at a 19-month follow-up. Consistent with the neurodevelopmental model of schizophrenia, patients demonstrated deficits in cognitive performance at initial testing and did not show decline at follow-up. There were no differences in neuropsychological performance over time between first-episode and previously treated patients, nor between male and female patients or controls. As expected, patients improved clinically with treatment with respect to both positive and negative symptoms. First-episode patients improved more on the positive symptoms of hallucination and delusion; male and female patients showed equivalent clinical improvement. Clinical improvement correlated positively with neuropsychological change, with improved negative symptomatology accounting for most of the significant correlations.

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Section: Discussioncontrasting

confidence: 54%

“…Cross-sectional studies suggest that negative symptoms correlate more with neuropsychological change than do positive symptoms (Bilder et al, 1985;Andreasen et al, 1990;Shtasel et al, 1992a). Longitudinally, Saykin et al (submitted for publication) found correlations between improvement in negative symptoms and neuropsychological change.…”

Section: Introductionmentioning

confidence: 99%

Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia: a longitudinal study

Censits

Ragland

Gur

et al. 1997

Schizophrenia Research

255

142

View full text Add to dashboard Cite

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“…After informed consent was obtained, participants underwent standard comprehensive screening , including medical history, physical examination, laboratory tests, and assessment procedures (Shtasel et al, 1992;Gur et al, 1991). These included the patient edition of the SCID (SCID-P; Spitzer et al, 1996), and scales for measuring symptomatology and functioning administered by investigators trained to a criterion reliability of 0.90, intraclass correlation (Shtasel et al, 1992). Entry criteria included (a) a diagnosis of schizophrenia or schizophreniform disorder by DSM-IV criteria, (b) no concomitant axis I or II disorder, including past or present substance abuse or dependence, and (c) no medical or neurological disorder that may affect brain function.…”

Section: Methods Participantsmentioning

confidence: 99%

“…For example, in their original formulation and description of the QLS, Henrichs et al (1984) showed that 52% of the variance in their study was explained by an Interpersonal Relations factor consisting of items 1-8 of the scale, while only 22% of the variance was explained by the other three factors combined. More recently, in a study of sex differences in clinical expression of schizophrenia (Shtasel et al, 1992), we showed that a factor analysis of QLS ratings for 107 patients with schizophrenia revealed three factors: (1) social functioning (items 2-8, 16), (2) engagement (items 1, 13-15, 18-21), and (3) vocational functioning (items 9-11, 12, 17). Others have noted that the four subscales of the QLS are highly related, and provide little additional information beyond the total score.…”

Section: Introductionmentioning

confidence: 98%

Development of an Abbreviated Schizophrenia Quality of Life Scale Using a New Method

Bilker

Brensinger

Kurtz

et al. 2002

Neuropsychopharmacol

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The goal of the study was to develop and apply a predictive model approach to reduce the number of items collected for scales that yield a total summary score. A parsimonious subset of items from the 21-item Quality of Life Scale (QLS) that can accurately predict the total scale score was sought and evaluated in 198 patients with schizophrenia, using a statistical modeling approach. Two additional data sets were used for model validation: the subset of 101 patients used in the model construction who had the QLS administered approximately 1 year later and a new sample of 37 patients. Using only seven QLS items as predictors, the correlation was 0.9831 between the predicted and true QLS totals. Applying the model based for these seven QLS items, the correlations from the first and second validation data sets were 0.9791 and 0.9637, respectively. The study demonstrates that a small subset of items of the QLS predicts the entire 21-item scale with high accuracy. Two validation samples have confirmed the finding. This reduces the effort associated with scale administration and is likely to increase the assessment of an important functional domain. Such models can guide efforts for item reduction in other rating instruments.

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“…It is generally accepted that the symptom profile and severity of symptoms are very similar for patients with established schizophrenia and psychosis. 116 These QoL values are therefore potentially useful for the economic evaluation and are reviewed and reported in Appendix 9. As Voruganti and colleagues 117 reported later results from the same study as Awad and colleagues 52 only the study by Voruganti and colleagues 117 is summarised in Appendix 9.…”

Section: Review Of Utility-based Qol Papers In Fepmentioning

confidence: 99%

Structural neuroimaging in psychosis: a systematic review and economic evaluation

Albon¹,

Tsourapas²,

Frew³

et al. 2008

Health Technol Assess

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Phenomenology and Functioning in First-Episode Schizophrenia

Cited by 99 publications

References 41 publications

Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia: a longitudinal study

Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia: a longitudinal study

Development of an Abbreviated Schizophrenia Quality of Life Scale Using a New Method

Structural neuroimaging in psychosis: a systematic review and economic evaluation

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