Phenomenological model for interpreting the clinical significance of the in vitro optical transfer function

Abstract

We describe a methodology to predict the outcome of clinical tests caused by changes made to the optical elements of the human eye. This formalism, called the expected visual outcome model, is based on in vitro measurements of the optical transfer function and takes into account a simple model of human threshold performance. The clinical tests under consideration are high-contrast visual acuity and contrast sensitivity. Using the expected visual outcome, we describe a useful performance index called the predicted visual acuity graph, which can be measured clinically. The theoretical results are compared with visual function measured in patients with pseudophakic (multifocal and monofocal) implants.

Modulation transfer function of intraocular collamer lens with a central artificial hole

“…MTF measurements in vitro are the internationally accepted standard method for evaluating the performance of IOL image quality, and it has been reported that one can predict contrast sensitivity in vivo from contrast values in vitro [7]. Furthermore, Kawamorita et al reported that this measurement has high repeatability [8].…”

Modulation transfer function and pupil size in multifocal and monofocal intraocular lenses in vitro

“…14 We analyzed the MTFs of multifocal and monofocal IOLs and investigated the relationship to the pupil size.…”

Computational aspects of the through-focus characteristics of the human eye

“…Calculating through-focus characteristics of the human eye's optical system has a wide variety of important applications including assessing the efficacy of intraocular lenses [1][2][3], studying the depth-of-field and the sensitivity to optical blur [4][5][6], assessing the role of higher order aberrations [7,8], assessing the optical changes induced by a refractive surgery [9], and studying the role of retinal image quality in refractive error development [10].…”