Phenolic profile, antioxidant and antifungal activity of extracts from four medicinal plants of the Anacardiaceae family

Neves, Andréa Maria; Fontenelle, Raquel Oliveira dos Santos; Lopes, Flávio Silva; Mendes, Josilayne de Fátima Souza; Rodrigues, Ana Livya Moreira; Marinho, Márcia Machado; Marinho, Emmanuel Silva; Morais, Selene Maia de

doi:10.33448/rsd-v10i8.17421

Cited by 6 publications

(3 citation statements)

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“…Such improvements suggest robust antidepressant activity, potentially mediated by the extract's alkaloidal and polyphenolic content, which interact with neurotransmitter pathways and reduce oxidative stress (Rebas et al, 2020). These results align with previous studies that reported similar antidepressant effects of A.occidentale extracts, which were attributed to its rich phytochemical content, particularly alkaloids and phenolics (Neves et al, 2021).…”

Section: Behavioral Outcomes In Depression-induced Male Micesupporting

confidence: 89%

Antidepressant Potential of Anacardium Occidentale Linn.: A Phytochemical, in Vivo, and in Silico Evaluations

Senjobi,

Soremekun

et al. 2024

Preprint

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Clinical depression, a prevalent mental disorder, poses significant challenges worldwide, coupled with the adverse effects of its current pharmacotherapies. This study explores the antidepressant potential of Anacardium occidentale, a plant known for its pharmacological properties, aiming to offer a safer, more effective alternative for treating clinical depression. We conducted qualitative phytochemical screening of A. occidentale leaves and assessed the antidepressant activity using behavioural tests (Tail Suspension Test and Forced Swim Test) on Swiss albino mice. Additionally, molecular docking and pharmacokinetic screening were performed to evaluate the interaction and efficacy of the plant’s bioactive compounds with serotonin and norepinephrine transporters. The phytochemical analysis identified multiple bioactive compounds, predominantly alkaloids and phenolics. Behavioural tests indicated significant antidepressant activity at dosages of 200mg/kg and 400mg/kg, comparable to the standard drug Amitriptyline. Molecular docking highlighted strong binding affinities of the bioactive compounds, particularly Epigallocatechin and Quercetin, to serotonin and norepinephrine transporters. Pharmacokinetic profiles suggested favourable absorption and metabolic characteristics, although some compounds exhibited potential toxicity risks. In conclusion, A. occidentale demonstrated potential as an effective natural antidepressant, influenced by its rich phytochemical content. The computational and in vivo findings suggest that specific compounds could serve as viable candidates for further drug development, with the potential to mitigate the limitations of current antidepressant therapies. Further research is recommended to validate these findings and advance clinical applications.

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Section: Behavioral Outcomes In Depression-induced Male Micesupporting

confidence: 89%

Antidepressant Potential of Anacardium Occidentale Linn.: A Phytochemical, in Vivo, and in Silico Evaluations

Senjobi,

Soremekun

et al. 2024

Preprint

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“…About 14 genera and 56 species, with 1 genus and 16 species endemic to Anacardiaceae, have been identified in Brazil. In the TSC, four medicinal species were identified, being rich in secondary metabolites with great therapeutic potential, such as antioxidant and antimicrobial effects (Antônio, 2016;Neves et al, 2021;Ramadan et al, 2010).…”

Section: Forest Biomass Sourcesmentioning

confidence: 99%

Small and medium-scale biorefineries: Biomass quantification and its bioeconomic potential in the Southern Coastal Territory of Bahia

Santos

Callefi

Ianda

et al. 2023

Preprint

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Biomass has been profiled as a potential source of a portfolio of value-added products and energy vectors with applications in different industrial sectors. The Territory of the Southern Coast of Bahia (TSC) in Brazil has a high potential to provide agricultural and forest biomass to small and medium-scale biorefineries. The Territory of the Southern Coast of Bahia (TSC) in Brazil has a high potential to provide agricultural and forest biomass for these bioindustries. This work aims to quantify the biomass of the main agricultural crops of the TSC over the period of 1999 to 2019. For this purpose, the biomass classification in the Municipal Agricultural Production (PAM) of the Brazilian Institute of Geography and Statistics (IBGE) was used, according to its applications in pharmaceutical industries and other industries using the Classification and Regression Tree (CART) algorithm. Moreover, the identification of the main forest species of the Atlantic Forest that can supply bio-based products was included. Thus, a time series analysis was performed. Biomass classification was performed with the inverted tree using the Gini Index. The results indicate that banana production (1.3 Mt) exceeded, over a period of 20 years, cocoa production (1.1 Mt). This occurs despite the higher occupying area of cocoa (5.8 million hectares) compared with that of bananas. Coffee biomass has been profiled as a raw material to be upgraded in various industries, while bananas are oriented toward supplying inputs for the pharmaceutical industry. Forest species also have the potential to be used in the pharmaceutical industry. In conclusion, small and medium-scale biorefineries can help to increase the use of agricultural and forest biomass as a way of providing inputs for several industries and guaranteeing positive social impacts for the population.

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“…According to Neves et al. [ 19 ], ethanol extracts of Anacardiaceae species can be potential sources of new biotechnological products, acting as natural antioxidant and antifungal agents. However, UAE has been used to extract phenolic compounds and determine antioxidant activity from mulberry pulp [ 20 ], Genipap berry fruit pulp [ 21 ], jackfruit pulp [ 22 ], peaches fruit pulp [ 23 ], and apple pulp [ 24 ] among many other plants with nutritional or medicinal effects.…”

Section: Introductionmentioning

confidence: 99%

Optimization of ultrasound-assisted extraction of phenolic content & antioxidant activity of hog plum (Spondias pinnata L. f. kurz) pulp by response surface methodology

Ahmed

Rana²,

Maisha³

et al. 2022

Heliyon

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Phenolic profile, antioxidant and antifungal activity of extracts from four medicinal plants of the Anacardiaceae family

Cited by 6 publications

References 56 publications

Antidepressant Potential of Anacardium Occidentale Linn.: A Phytochemical, in Vivo, and in Silico Evaluations

Antidepressant Potential of Anacardium Occidentale Linn.: A Phytochemical, in Vivo, and in Silico Evaluations

Small and medium-scale biorefineries: Biomass quantification and its bioeconomic potential in the Southern Coastal Territory of Bahia

Optimization of ultrasound-assisted extraction of phenolic content & antioxidant activity of hog plum (Spondias pinnata L. f. kurz) pulp by response surface methodology

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