Phenolic Profile and Antioxidant Potential of Leaves from Selected Cotoneaster Medik. Species

Abstract

Abstract:The antioxidant efficiency of 70% aqueous methanolic extracts from the leaves of twelve selected Cotoneaster Medik. species was evaluated using four complementary in vitro tests based on SET-(single electron transfer) and HAT-type (hydrogen atom transfer) mechanisms (DPPH, FRAP, O 2 ‚´a nd H 2 O 2 scavenging assays). The samples exhibited the dose-dependent responses in all assays with activity parameters of EC 50 = 18.5-34.5 µg/mL for DPPH; 0.9-3.8 mmol Fe 2+ /g for FRAP; SC 50 = 27.7-74.8 µg/mL for O 2 ‚´; and SC 50 = 29.0-91.3 µg/mL for H 2 O 2 . Significant linear correlations (|r| = 0.76-0.97, p < 0.01) between activity parameters and total contents of phenolics (5.2%-15.4% GAE) and proanthocyanidins (2.1%-15.0% CYE), with weak or no effects for chlorogenic acid isomers (0.69%-2.93%) and total flavonoids (0.28%-1.40%) suggested that among the listed polyphenols, proanthocyanidins are the most important determinants of the tested activity. UHPLC-PDA-ESI-QTOF-MS analyses led to detection of 34 polyphenols, of which 10 B-type procyanidins, 5 caffeoylquinic acids and 14 flavonoids were identified. After cluster analysis of the data matrix, the leaves of Cotoneaster zabelii, C. splendens, C. bullatus, C. divaricatus, C. hjelmqvistii and C. lucidus were selected as the most promising sources of natural antioxidants, exhibiting the highest phenolic levels and antioxidant capacities, and therefore the greatest potential for pharmaceutical applications.

Phytochemicals in leaves of Cotoneaster mongolica, their antioxidative, and acetylcholinesterase inhibitory activity

“…The anti-oxidative activity of 70 % methanol extracts of leaves from 12 species of Cotoneaster Medik. varied between EC 50 , 18.5-34.5 μg/mL [13]. The leaf methanol extract of C.melanocarpus showed activity with IC 50 , 106.41 μg/mL [4].…”

Protective effects of Cotoneaster integerrimus on in vitro and ex-vivo models of H2 O2 -induced lactate dehydrogenase activity in HCT116 cell and on lipopolysaccharide-induced inflammation in rat colon

“…Multiple studies have investigated the protective effects of extracts of members of this genus including the antioxidant, anticancer, hepatoprotective, antidiabetic, and antidyslipidemic activities of C. horizontalis (Mohamed, Sokkar, El‐Gindi, Zeinab, & Alfishawy, ; Sokkar et al, ), antioxidant activity of C. zabelii , C. splendens , C. bullatus , C. divaricatus , C. hjelmqvistii , and C. lucidus (Kicel et al, ), anticholinesterase and antioxidant potential of C. meyeri and C. morulus (Ekin, Gokbulut, Aydin, Donmez, & Orhan, ), antioxidant, antibacterial, anticholinesterase, antityrosinase, antiamylase, and antiglucosidase activity of C. nummularia (Ekin et al, ; Zengin et al, ).…”

Pouvoir antioxydant et teneurs en composés phénoliques de deux espèces du genre Albertisia: Albertisia cordifolia (Mangenot & J. Miège) Forman et Albertisia scandens (Mangenot & J. Miège) Forman (Menispermaceae)

“…Pour faire face à ce désordre, les antioxydants sont préconisés, les plus utilisés étant ceux de synthèse. Cependant, l'utilisation des molécules antioxydantes synthétiques disponibles est, actuellement, remise en cause en raison des risques potentiels pour la santé et de la toxicité qu'elles sont capables de provoquer (Kicel et al, 2016 ;Liu & Yang, 2018). C'est pourquoi, l'accent est, de plus en plus, mis sur la recherche de nouvelles sources d'antioxydants dont les plantes médicinales (Liu et al, 2017 ;Wang et al, 2018).…”