Phenolic, iridoid and ionyl glycosides from Homalium ceylanicum

Bioactive Phenolic and Isocoumarin Glycosides from the Stems of Homalium paniculiflorum

“…Among which, H. paniculiflorum is a Chinese endemic plant, only distributed in China’s Hainan Island [1]. Previous phytochemical investigations on the genus have afforded various types of compounds including phenolic glycosides, xanthenes, iridoids, coumarins, triterpenoids and alkaloids, which showed a wide variety of interesting bioactivities including anti-bacterial, anti-oxidant, anti-viral, anti-plasmodial, hypolipidemic and hypoglycemic activities [2,3,4,5,6,7,8,9,10,11]. As a Chinese endemic medicinal plant, up to now, there is only a preliminary investigation on the chemical composition of H. paniculiflorum performed by us recently [10,11].…”

“…As a Chinese endemic medicinal plant, up to now, there is only a preliminary investigation on the chemical composition of H. paniculiflorum performed by us recently [10,11]. As a part of our ongoing research into structurally and biologically interesting natural products from tropical medicinal plants in China, a further chemical investigation on H. paniculiflorum was undertaken and had led to the isolation of two new phenolic glycosides and two new isocoumarin glycosides ( 1 – 4 ) (Figure 1), along with 14 known compounds, vanillin ( 5 ) [12], 2,4-dihydroxybenzaldehyde ( 6 ) [13], 4-hydroxy-3,5-dimethoxybenzaldehyde ( 7 ) [14], β -hydroxypropiovanillone ( 8 ) [15], coniferaldehyde ( 9 ) [16], 2-hydroxy phenyl- β -glucoside ( 10 ) [17], helicin ( 11 ) [18], salirepin ( 12 ) [4], salireposide ( 13 ) [3], homaloside B ( 14 ) [3], poliothrysoside ( 15 ) [19], itoside H ( 16 ) [20], 3-phenylisocoumarin ( 17 ) [7] and 3-(3′-hydroxyphenyl) isocoumarin ( 18 ) [8]. The structures of the new compounds 1 – 4 were elucidated by extensive spectroscopic analyses and chemical methods, while the known compounds were identified by comparisons their data with those reported in the literature.…”

First total chemical synthesis of natural acyl derivatives of some phenolglycosides of the family Salicaceae

“…Salireposide was found out in many plants [8][9][10][11][12][13] . Populosides A, B, C were first isolated from Populus davidiana in 2006 7 , and populoside A was also isolated from P. ussuriensis 14 .…”

“…tetra-О-acetyl-β-D-glucopyranosyloxy) benzyl alcohol(11,12,13).General method. To 0.7 mmol of correspond glycoside(8 -10) dissolved in 5 mL CHCl 3 , was added a solution of NaBH 4 (0.7 mmol) in 2 mL water and 0.0025 g (1% mol) CTMABr.…”

Benzyl Glycosides from the Aerial Parts of Gynostemma laxum and Their NF-κB Inhibitory Activity in HepG2 Cells

“…4,5 In the HMBC spectrum (see Figure 2), two proton signals at δ H 4.45 and 4.50 of oxygenated methylene group correlated with carbons C-1 (δ C 126.3), C-2 (δ C 148.1), and C-6 (δ C 126.4); one proton signal at δ H 7.25 (H-6) correlated with carbons C-2 (δ C 148.1), C-4 (δ C 154.0), and C-7 (δ C Figure 1. Structures of isolated compounds 1-10 from Gynostemma laxum.…”