Phenolic content, antioxidant, anti-inflammatory and anticancer activities of the edible halophyte Suaeda fruticosa Forssk

Oueslati, Samia; Ksouri, Riadh; Falleh, Hanen; Pichette, André; Abdelly, Chédly; Legault, Jean

doi:10.1016/j.foodchem.2011.11.072

Cited by 127 publications

(91 citation statements)

References 26 publications

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“…The proanthocyannidins were determined by spectrophotometer method [27,28] . This method relies on the reaction with vanillin under acidic conditions.…”

Section: Total Condensed Tannin Content Determinationmentioning

confidence: 99%

Study on the antioxidant activities of root extracts of Zizyphus lotus from the western region of Algeria

Ghalem¹,

Merghache²,

Belarbi³

2014

Phcog J.

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Objective: To find a new natural source of antioxidant, the phenolic contents and antioxidant activities of some secondary metabolites extracted from roots of Ziziphus lotus were evaluated. Methods: The total polyphenol contents were determined spectrophotometrically. Pyrrocatechol, catechin and cyanidin equivalents were used for these parameters. The antioxidant activities of the extracts were determined by several in vitro systems of assays, namely DPPH radical scavenging activity method, b-Carotene Bleaching assay (BCB), Ferric Reducing Antioxidant Power assay (FRAP) and Total Antioxidant capacity test (TAC). Results: The quantitative estimation showed that the roots of Z. lotus were rich in polyphenols (20.09 mg PE/g DW) and proanthocyannidins (1.56%) and they contained a small amount of flavonoids (0.02 mg CE/g DW). The most fractions exhibited high antioxidant activities, and some even showed higher potency than the standard synthetic antioxidants in some instances. In DPPH assay, all extracts had shown significant inhibition (58.535 -94.730% at 1 mg/mL). In addition, the IC 50 values ranged from 0.211 to 0.816 mg/mL, compared to 0.110, 0.214, 0.214 and 0.413 mg/mL for gallic acid, tannic acid, butylated-hydroxyanisol and ascorbic acid respectively. In (BCB) assay, the extracts showed strong inhibition (55.55 -100.00% at 1 mg/mL) and the IC 50 values ranging from 0.123 to 0.850 mg/mL compared to 0.433 mg/mL for gallic acid. A dose dependant curve was obtained for all extracts in the FRAP assay. However, the antioxidant potencies of ascorbic acid and extracts were comparable at low concentrations. The majority of extracts showed the highest value of antioxidant activity, based on TAC test (0.073 -0.398 mg ascorbic acid / mg extract). Conclusion: The results indicate that Z. lotus roots could be an important sources of natural antioxidants.

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“…The proanthocyannidins were determined by spectrophotometer method [27,28] . This method relies on the reaction with vanillin under acidic conditions.…”

Section: Total Condensed Tannin Content Determinationmentioning

confidence: 99%

Study on the antioxidant activities of root extracts of Zizyphus lotus from the western region of Algeria

Ghalem¹,

Merghache²,

Belarbi³

2014

Phcog J.

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“…In recent years, plant-derived bioactive substances especially anticancer ones have gained considerable attention [32]. Moreover, many plants containing phenolic compounds have been found to possess good anticancer activity [33,34] and based on this fact plants rich in phenolic content have been considered as interesting in developing anticancer drug [35,36].…”

Section: Resultsmentioning

confidence: 99%

Gas Chromatography-Mass Spectrometry Analysis, in Vitro Cytotoxic and Antioxidant Efficacy Studies on Cleome Gynandra L. (Leaves): A Traditional Drug Source

Saravanan

Brindha

Narayanan

et al. 2017

Asian J Pharm Clin Res

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Objective: This study was aimed to assess the phytoconstituents, cytotoxic, and antioxidant efficacy of ethyl extract of Cleome gynandra leaves.Methods: Qualitative phytochemical analysis with different solvent extracts was performed. Quantitative and gas chromatography-mass spectrometry (GC-MS) analysis of the extract was performed with ethyl acetate extract. The cytotoxic effect of the ethyl acetate extract was determined by 3-[4,5-dimethylthiazol-2-yl]2,5-diphenyltetrazolium bromide (MTT) assay on Michigan Cancer Foundation-7 (MCF-7) cells using taxol as standard and free radical scavenging ability using 1,1-diphenyl-2-picrylhydrazyl (DPPH). Results:Leaves extracts with different solvents revealed the presence of alkaloids, cardiac glycosides, flavonoids, phenols, and tannins. GC-MS analysis of ethyl acetate of the plant leaves showed the presence of n-hexadecanoic acid. The IC 50 value of the ethyl acetate extract was found to be 90.2 μg/ml on MCF-7 cell line, and the extract was found to possess significant DPPH free radical scavenging activity. Conclusion:From the results, we conclude that the C. gynandra extract possesses antioxidant and antiproliferating activity against MCF-7 cells.

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“…Estimation of total phenolic content: The total phenolic content was estimated by using Folin-ciocalteu reagent assay [5] where gallic acid was used as the standard. 1 ml of the test sample/standard solution of gallic acid was added with 0.5 ml distilled water followed by 0.125 ml 1N Folin-ciocalteu reagent (Himedia), shaken well and allowed to stand for 6 min.…”

Section: Quantitative Phytochemical Profiling Of Some Important Seconmentioning

confidence: 99%

Phytochemical Profiling and Antibacterial Efficacy Screening of Aglaia Malabarica Sasidh

Ravindran

Thoppil

2018

Int J Curr Pharm Sci

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Objective: Aglaia malabarica is an unexplored endemic forest tree belonging to the family Meliaceae. The present study was conducted to screen the phytochemical constituents of the leaf extract, to analyze the important secondary metabolites and to determine the antibacterial efficacy of the plant extract.Methods: Antibacterial activity was studied using agar based disc diffusion method. Four strains of bacteria were used for the antibacterial study that includes Staphylococcus aureus, Pseudomonas aeruginosae, Proteus vulgaris and Bacillus megaterium. Results:The presence of constituents like, carbohydrates, proteins, tannins, phenols, terpenoids, flavonoids, alkaloids and steroids were confirmed. Saponin was found to be absent. The secondary metabolites quantified were terpenoids, phenols and flavanoids, which were found in considerable amounts. The minimum inhibitory concentration (MIC) of all the bacteria studied was found to be 500 µg methanolic leaf extract. Conclusion:The plant extract was found to be highly potent against both the Gram positive and Gram negative strains and this property may be attributed to the potent phytochemicals revealed in the extract.

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Phenolic content, antioxidant, anti-inflammatory and anticancer activities of the edible halophyte Suaeda fruticosa Forssk

Cited by 127 publications

References 26 publications

Study on the antioxidant activities of root extracts of Zizyphus lotus from the western region of Algeria

Study on the antioxidant activities of root extracts of Zizyphus lotus from the western region of Algeria

Gas Chromatography-Mass Spectrometry Analysis, in Vitro Cytotoxic and Antioxidant Efficacy Studies on Cleome Gynandra L. (Leaves): A Traditional Drug Source

Phytochemical Profiling and Antibacterial Efficacy Screening of Aglaia Malabarica Sasidh

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