Phenolic Content Analysis And Evaluation of Antinociceptive, Antioxidant, Anti-Inflammatory Potential of Alternanthera Pungens Kunth

Abstract

The present study evaluated the analgesic, anti-inflammatory and antioxidant activities of Alternanthera pungens kunth.The ethanolic extract of Alternanthera pungens (EAP) showed analgesic effects by exerting ameliorated reaction time 40.79% and 44.74% at a dose of 250 and 500 mg/kg,respectively, whereas standard was 41.78% by the hot plate test. Results of writhing inhibition were statistically significant (p <0.05) when compared to control. In addition to that, anti-inflammatory effects were also evaluated against denaturation of protein and the result was significant. Scavenging activity of EAP was 80.95% at the concentration of 800µg/mL. Moreover, HPLC-DAD analysis of EAP was also carried out to determine the presence of phenolic constituents & noted the presence of epicatechin,vanillin, p-coumaric acid etc. These studies inferred that EAP possesses analgesic, anti- inflammatory and antioxidant potential which might be due to presence of phytochemicals like flavonoids, tannins and phenolic compounds.
 Journal of Bangladesh Academy of Sciences, Vol. 42, No. 2, 129-136, 2018

Amaranthaceae plants of Israel and Palestine: Medicinal activities and unique compounds

“…Analgesic and pain related activities Whole plant ethanolic extract was prepared and tested for analgesic activity in mice by hot plate test and acetic acid-induced writhing test. 210 Antibacterial, antifungal, antiviral and related activities Aerial parts were separately extracted with water, acetone, ethanol and petroleum ether. All extracts were tested for antibacterial activity and ethanolic extract was most active.…”

“…211 Whole plant ethanolic extract was prepared and tested for antioxidant (DPPH) and anti-inflammatory (albumin denaturation technique) activities in mice. 210 Even though a detailed NMR work is reported, but the analyzed compounds are previously known phenolics. These were tested for antioxidant capacity (Trolox test).…”