Phenolic Constituents of Licorice (Glycyrrhiza Species)

Nomura, Taro; Fukai, Toshio

doi:10.1007/978-3-7091-6480-8_1

Cited by 54 publications

(41 citation statements)

References 269 publications

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“…In addition to glycyrrhizin, many triterpene saponins and flavonoids have been isolated from Glycyrrhiza plants. Moreover, the chemical constituents of licorice have been extensively studied (Nomura and Fukai 1998).…”

Section: Glycyrrhizin-a Sweet-tasting Triterpene Saponinmentioning

confidence: 99%

Economic importance of licorice

Hayashi

Sudo²

2009

Plant Biotechnology

182

141

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Section: Glycyrrhizin-a Sweet-tasting Triterpene Saponinmentioning

confidence: 99%

Economic importance of licorice

Hayashi

Sudo²

2009

Plant Biotechnology

182

141

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“…The major component of licorice is glycyrrhizin or glycyrrhizic acid [10,17] that is hydrolyzed in the intestine to the active glycyrrhetic acid (GA) by β-glucuronidase [18]. GA in licorice extracts has been associated with mineralocorticoid excess [19] and is a potent inhibitor of 11-β-hydroxysteroid dehydrogenase, which can result in increased cortisol activity [20].…”

Section: Introductionmentioning

confidence: 99%

Chemopreventive Effects of Licorice and Its Components

Bode

Dong

2015

Curr Pharmacol Rep

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“…Chinese medicinal practitioners recommend licorice root for its life-enhancing properties and cure of injury or swelling and for detoxification (2,3). It is also used as a flavoring and sweetening agent in drug preparations, tobacco, chewing gums, candies and beverages (4-6).…”

Section: Introductionmentioning

confidence: 99%

18α-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes

Munirathinam

2011

Int J Oncol

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Abstract. Glycyrrhetinic acid is an active triterpenoid metabolite of glycyrrhizin abundantly present in licorice roots. Glycyrrhetinic acid exists as α and β stereo-isomeric forms. Both stereo-isomeric forms are known to have anti-inflammatory and anticancer activity. However, the effects and anticancer mechanism of α glycyrrhetinic acid in prostate cancer cells has not yet been evaluated. Therefore, we investigated the growth inhibition, induction of apoptosis and the anticancer mechanisms of 18α-glycyrrhetinic acid (AGA), on the androgen-independent metastatic prostate cancer cell line DU-145. Our results showed that AGA inhibited proliferation and growth of these cells by inducing apoptosis as determined by Annexin V and flow cytometry analyses. Our studies also showed that HUVEC tube formation was drastically reduced when cultured in conditioned medium of AGA-treated DU-145 cells. In addition, AGA treatment prevented the invasion of DU-145 prostate cancer cells on matrigel coated transwells via down-regulation of NF-κB (p65), VEGF and MMP-9 expression. Furthermore, AGA treatment also downregulated the expression of pro-inflammatory cytokine/growth factor genes HMGB1, IL-6 and IL-8 in DU-145 cells. Interestingly, AGA simultaneously upregulated the expression of non-steroidal anti-inflammatory gene-1 (NAG-1) in DU-145 cells suggesting its anti-inflammatory activity on prostate cancer cells. Taken together, the results of this study suggest that AGA may be a promising anticancer agent that merits further investigation for the chemoprevention and treatment of prostate cancer.

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Phenolic Constituents of Licorice (Glycyrrhiza Species)

Cited by 54 publications

References 269 publications

Economic importance of licorice

Economic importance of licorice

Chemopreventive Effects of Licorice and Its Components

18α-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes

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