Phenolic compounds with IL-6 inhibitory activity from Aster yomena

Kim, A Ryun; Jin, Qinglong; Jin, Hongguang; Ko, Hae Ju; Woo, Eun‐Rhan

doi:10.1007/s12272-013-0236-x

Cited by 47 publications

(29 citation statements)

References 17 publications

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“…Isoquercitrin is a well-known antioxidant [31] with free radical scavenging activity [32]. It shows antiallergic [33] and anti-inflammatory effects in vitro [34,35] as well as in vivo [36]. In this current study, we analyzed the whole decoction and demonstrated a significant inhibitory influence on the inflammatory process of human immunocompetent cells.…”

Section: Discussionmentioning

confidence: 71%

In Vitro Anti-inflammatory Effects of Equisetum arvense Are Not Solely Mediated by Silica

et al. 2017

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, known as common horsetail, is used for the treatment of inflammatory diseases and is the plant with the highest concentration of silica. Yet it is unknown if the medicinal properties are mediated by its silica content. In the current study, optimal conditions for silica-rich horsetail preparations were identified. Bioactivity of the preparations was analyzed using flow cytometry-based activity and functionality profiling of primary human lymphocytes as well as cytokine measurement using a classical ELISA technique. Experiments revealed that horsetail preparations suppress activation and proliferation of lymphocytes by an interleukin-2-dependent mechanism. The effect increased with the silica concentration in the decoctions. Lymphocytes' polyfunctionality was also influenced, shown by a downregulation of IFN-. Analytical profiling by HPLC-UV-MS and bioactivity testing revealed relevant immunosuppressive concentrations of a component that has been identified as isoquercitrin. Our results show that both silica and isoquercitrin are active compounds of horsetail preparations.

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Section: Discussionmentioning

confidence: 71%

In Vitro Anti-inflammatory Effects of Equisetum arvense Are Not Solely Mediated by Silica

et al. 2017

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“…Subfraction D113 (900.9 mg) was subjected to silica gel CC using a gradient solvent system of chloroform:MeOH (30:1 → 100% MeOH). Of the six subfractions that were collected (D1131-D1136), subfraction D1135 (113.2 mg) was purified by semipreparative high-performance liquid chromatography (75% MeOH), resulting in the isolation of compound 1 (apigenin, 3.9 mg) [9]. Apigenin was dissolved in dimethyl sulfoxide to reach a final concentration of 10 mg/ml.…”

Section: Reagentmentioning

confidence: 99%

“…Aster yomena is a perennial herb that is found mainly in South Korea [9]. In traditional Korean Buddhism, A. yomena is included in a mix of vegetables and spices that are valued for their medical effects [10,11].…”

Section: Introductionmentioning

confidence: 99%

Apigenin promotes antibacterial activity via regulation of nitric oxide and superoxide anion production

2020

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Apigenin is a naturally occurring flavone isolated from the medicinal herb, Aster yomena. The present study was designed to elucidate the apoptosis‐like antibacterial mechanism of apigenin in Escherichia coli. Administration of apigenin resulted in a rapid increase in intracellular calcium accompanied by an increase in reactive nitrogen species (RNS) and nitric oxide (NO) levels. Furthermore, apigenin increases reactive oxygen species (ROS), superoxide anion (O2–) which left E. coli with no ability to activate superoxide dismutase. Finally, we found that perturbance of the membrane lipid bilayer leading to glutathione oxidation and formation 8‐hydroxy‐2′‐deoxyguanosine occurred during the process and apoptosis‐like death hallmarks were further observed. Furthermore, we applied the NO synthase inhibitor ( l‐NAME) and the O2– scavenger (Tiron) and observed attenuation in apoptotic markers under their presence. Taken together, these results suggest that apigenin induces bacterial apoptosis via activation of cellular oxidative pathways dependent on the production and accumulation of RNS/ROS.

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“…It is extracted and its chemical structure was identified according to Kim et al's method (Supporting Information Fig. S1) (8). A stock solution of ISO was dissolved in dimethyl sulfoxide (DMSO) and stored at −20 C. In all experiments, DMSO was used at <5% of the total volume (18).…”

Section: Preparation Of Iso and Antifungal Agentsmentioning

confidence: 99%

Synergistic Antifungal Activity of Isoquercitrin: Apoptosis and Membrane Permeabilization Related to Reactive Oxygen Species in Candida albicans

2018

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Isoquercitrin (ISO), one of phytochemical isolated from aerial parts of Aster yomena, has been reported to have antifungal activity. However, the synergistic effect and the mechanism of ISO in combination with conventional antifungal agents are poorly understood. Therefore, synergistic antifungal effect between ISO and conventional antifungal agents was investigated. ISO at non‐antifungal concentration interacts synergistically with amphotericin B (AMB) and fluconazole (FLC), but the combination with flucytosine (5‐FC) showed no interaction. ISO disrupted an antioxidant system by inhibiting the activity of superoxide dismutase. This redox imbalance was shown to induce intracellular reactive oxygen species (ROS) accumulation and oxidative stress. ISO combined with FLC caused metacaspase activation and DNA condensation, markers of apoptosis, higher than the combination with ISO/AMB. In contrast, ISO with AMB synergistically stimulated membrane permeabilization compared to ISO/FLC. Scavenging ROS consequently reduced the synergy‐induced apoptosis and membrane permeabilization, indicating combinations induced ROS were associated with the synergy effect of ISO. In conclusion, AMB and FLC enhanced the antifungal potency of ISO through oxidative stress when used in synergy. © 2018 IUBMB Life, 71(1):283–292, 2019

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Phenolic compounds with IL-6 inhibitory activity from Aster yomena

Cited by 47 publications

References 17 publications

In Vitro Anti-inflammatory Effects of Equisetum arvense Are Not Solely Mediated by Silica

In Vitro Anti-inflammatory Effects of Equisetum arvense Are Not Solely Mediated by Silica

Apigenin promotes antibacterial activity via regulation of nitric oxide and superoxide anion production

Synergistic Antifungal Activity of Isoquercitrin: Apoptosis and Membrane Permeabilization Related to Reactive Oxygen Species in Candida albicans

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