In Vitro Anti-inflammatory Effects of Equisetum arvense Are Not Solely Mediated by Silica

Steinborn, Carmen; Potterat, Olivier; Meyer, Ulrich; Trittler, Rainer; Stadlbauer, Sven; Huber, Roman; Gründemann, Carsten

doi:10.1055/s-0043-123075

Cited by 11 publications

(13 citation statements)

References 32 publications

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“…This relates to AM remedies, to understand their molecular, epigenetic, cellular, biochemical, physiological, pathophysiological, immunological, neurological, psycho-neuro-immunological mechanisms involved, the social context, etc. [43, 113, 114]. The same accounts to nonpharmacological interventions, lifestyle changes, or counseling: do they have effects on physiological rhythms, epigenetics, the psychosocial level, or on individual mental-cognitive developmental processes?…”

Section: Results: An Integrative Research Strategymentioning

confidence: 99%

Contributing to Global Health: Development of a Consensus-Based Whole Systems Research Strategy for Anthroposophic Medicine

Kienle

Ben‐Arye

Berger

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Background Whole medicine and health systems like traditional and complementary medicine systems (T&CM) are part of healthcare around the world. One key feature of T&CM is its focus on patient-centered and multimodal care and the integration of intercultural perspectives in a wide range of settings. It may contribute to good health and well being for people as part of the Sustainable Development Goals of the United Nations. The authentic, rigorous, and fair evaluation of such a medical system, with its inherent complexity and individualization, imposes methodological challenges. Hence, we propose a broad research strategy to test and characterize its possible contribution to health. Methods To develop a research strategy for a specific T&CM system, Anthroposophic Medicine (AM), applying multimodal integrative healthcare based on a four-level concept of man, we used a three-phase consensus process with experts and key stakeholders, consisting of (1) premeeting methodological literature and AM research review and interviews to supplement or revise items of the research strategy and tailor them to AM research, (2) face-to-face consensus meetings further developing and tailoring the strategy, and (3) postmeeting feedback and review, followed by finalization. Results Currently, AM covers many fields of medical specialties in varied levels of healthcare settings, such as outpatient and inpatient; primary, secondary, and tertiary care; and health education and pedagogy. It is by definition integrated with conventional medicine in the public healthcare system. It applies specific medicines, nursing techniques, arts therapies, eurythmy therapy, rhythmical massage, counseling, and psychotherapy, and it is provided by medical doctors, nurses, therapists, midwives, and nutritionists. A research strategy authentic to this level of complexity should comprise items with a focus on (I) efficacy and effectiveness, divided into (a) evaluation of the multimodal and multidisciplinary medical system as a whole, or of complex multimodal therapy concept, (b) a reasonable amount of methodologically rigorous, confirmatory randomized controlled trials on exemplary pharmacological and nonpharmacological therapies and indications, (c) a wide range of interventions and patient-centered care strategies with less extensive formats like well-conducted small trails, observational studies, and high-quality case reports and series, or subgroup analyses from whole-system studies, or health service research; (II) safety; (III) economics; (IV) evidence synthesis; (V) methodologic issues; (VI) biomedical, physiological, pharmacological, pharmaceutical, psychological, anthropological, and nosological issues as well as innovation and development; (VI) patient perspective and involvement, public needs, and ethics; (VII) educational matters and professionalism; and (IX) disease prevention, health promotion, and public health. Conclusion The research strategy extends to and complements the prevailing hierarchical system by introducing a broad “evidence hous...

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Section: Results: An Integrative Research Strategymentioning

confidence: 99%

Contributing to Global Health: Development of a Consensus-Based Whole Systems Research Strategy for Anthroposophic Medicine

Kienle

Ben‐Arye

Berger

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…Briefly, the results of the present study demonstrated that the extract exhibits an antinociceptive effect in chemical models of nociception. In agreement with these results, Steinbor et al [85] verified the anti-inflammatory properties of E. arvense through its silica content, revealing that silica-rich horsetail preparations suppress lymphocytes' activation and proliferation by an interleukin-2-dependent mechanism and a downregulation of interferon gamma (IFN-c). Interestingly, analytical profiling by HPLC-UV-MS and bioactivity testing revealed significative immunosuppressive concentrations of a component that was identified as isoquercitrin.…”

Section: Other Properties Of Pharmacological Interestmentioning

confidence: 63%

Phytochemistry and Pharmacology of the Genus Equisetum (Equisetaceae): A Narrative Review of the Species with Therapeutic Potential for Kidney Diseases

Boeing

Moreno

Gasparotto

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The Equisetum genus, Equisetaceae family, is widely distributed worldwide and may be the oldest nonextinct genus on Earth. There are about 30 known species, which are very often used in traditional medicine with diverse applications. This review aimed to compile scientific reports about Equisetum species with relevant pharmacological properties and/or therapeutic potential for kidney diseases. Our bibliographic survey demonstrates that the most widespread traditional use of Equisetum is as a diuretic, followed by the treatment of genitourinary diseases (kidney diseases, urethritis, kidney stones, and others), inflammation, wound healing, rheumatic diseases, prostatitis, and hypertension. The most popular species from the Equisetum genus with medicinal use is E. arvense L., whose diuretic effect was confirmed in animal models and clinical trials. The species E. bogotense Kunth also demonstrated the beneficial effect of inducing diuresis in both experimental and clinical assays. Several other species have also been studied regarding their therapeutic potential, showing different biological actions. Regarding the chemical composition, it contains many active constituents, such as alkaloids, flavonoids, phenol, phytosterols, saponins, sterols, silicic acid, tannin, triterpenoids, and volatile oils. However, despite the widespread traditional use, many species need to be explored in detail for scientific validation of popular use. Indeed, the species of the Equisetum genus have great potential in the management of kidney disorders.

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“…The anti-cancer properties of Equisetum arvense are so well documented that a recent article published in 2020 states “[Equisetum arvense] may serve as an alternative anticancer agent for the treatment of pancreatic carcinoma with no or least side effects to the patient ” (73). Also the anti-inflammatory properties of the plant are well documented and the mechanism of action for the anti-inflammatory effect is based on modulation of interleukins and interferon (74). The rationale for using Equisetum arvense in the co-culture described above is based on two properties of the plant.…”

Section: Discussionmentioning

confidence: 99%

Experimental evidence for the role of natural radioactivity in influencing viability of commensal microorganisms

Ruggiero¹

2020

Preprint

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The role of natural radioactivity in influencing viability of commensal microorganisms, with particular reference to those pertaining to the human microbiota, has not been investigated in detail. The results of experiments culturing a diversified array of microorganims - probiotics - in naturally radioactive mineral water or deuterium-depleted water are here described. Culturing microorganisms in naturally radioactive mineral water yielded one order of magnitude more live microbial cells in comparison with culturing in deuterium-depleted water. Based on these experimental results, a method for co-culturing prebiotic microorganisms (cyanobacteria) that are extremely resistant to the harmful effects of radiations, together with the probiotics mentioned above, is described. The goal of this co-culture in naturally radioactive mineral water is to transfer the information from the radiation-resistant microorganisms to the probiotics whose viability is enhanced by natural radioactivity. Expression of DNA repair genes in cyanobacteria is induced by co-culturing in a medium of carbonated mineral water naturally containing the radioactive isotopes 228U and 226Ra. The culture medium, in addition to naturally radioactive water, contains silica from vegetal origin to enhance horizontal gene transfer. Finally, it is described the transfer of resistance to the harmful effects of radiations to human cells through a Lactococcus phage-encoded protein, ORF252, that is the evolutionary precursor of human proteins involved in DNA repair and cancer protection.

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In Vitro Anti-inflammatory Effects of Equisetum arvense Are Not Solely Mediated by Silica

Cited by 11 publications

References 32 publications

Contributing to Global Health: Development of a Consensus-Based Whole Systems Research Strategy for Anthroposophic Medicine

Contributing to Global Health: Development of a Consensus-Based Whole Systems Research Strategy for Anthroposophic Medicine

Phytochemistry and Pharmacology of the Genus Equisetum (Equisetaceae): A Narrative Review of the Species with Therapeutic Potential for Kidney Diseases

Experimental evidence for the role of natural radioactivity in influencing viability of commensal microorganisms

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