Phenolic compounds: The inhibition effect on polyol pathway enzymes

J Biochem & Molecular Tox

et al. 2019

109

Chrysin (CH) or 5,7-dihydroxyflavone is a flavonoid present in various plants, bee propolis, and honey. Cyclophosphamide (CYP) is a chemotherapeutic drug, which is extensively used in the treatment of multiple human malignancies. In our study, we aimed to investigate the effects of CYP and CH on some metabolic enzymes including carbonic anhydrase, aldose reductase, paraoxonase-1, α-glycosidase, acetylcholinesterase, and butyrylcholinesterase enzyme activities in the brain, heart, testis, liver, and kidney tissues of rats. Thirty-five adult male Wistar rats were used.The animals were pretreated with CH (25 and 50 mg/kg b.w.) for seven days before administering a single dose of CYP (200 mg/kg b.w.) on the seventh day. In all the tissues, the treatment of CH significantly regulated these enzyme activities in CYP-induced rats. These results showed that CH exhibited an ameliorative effect against CYP-induced brain, heart, liver, testis, and kidney toxicity.chrysin, cyclophosphamide, enzyme activities, in vivo, metabolic enzymes, rats

Section: Discussionmentioning

confidence: 81%

The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide‐induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities

Taslimi

Kandemir

J Biochem & Molecular Tox

et al. 2019

109

“…[56] Recently, there have been several research on the effects of phenolic compounds on glucose metabolism, particularly the polyol pathway. [57] As shown in Figure 1, AR enzyme activity was decreased in testis and lung tissues given of different doses of ZO (25 and 50 mg/kg) compared with control. α-Gly enzyme activity was reduced in all groups and all tissues.…”

Section: Discussionmentioning

confidence: 85%

“…AR inhibition may be preventing oxidative stress using natural chemicals . Recently, there have been several research on the effects of phenolic compounds on glucose metabolism, particularly the polyol pathway . As shown in Figure , AR enzyme activity was decreased in testis and lung tissues given of different doses of ZO (25 and 50 mg/kg) compared with control.…”

Section: Discussionmentioning

confidence: 95%

The effects of zingerone against vancomycin‐induced lung, liver, kidney and testis toxicity in rats: The behavior of some metabolic enzymes

Çağlayan

Taslimi

J Biochem & Molecular Tox

et al. 2019

In this study, it was demonstrated the ameliorative effect of zingerone (ZO) (25 and 50 mg/kg body weight) against vancomycin (VCM) (200 mg/kg body weight) administered to rats on some metabolic enzymes’ activities in the lung, liver, kidney, and testis tissues of rats. Forty‐two rats were divided into six groups as follows: control, ZO‐25, ZO‐50, VCM, VCM + ZO‐25, and VCM + ZO‐50. α‐Glycosidase, butyrylcholinesterase, aldose reductase, acetylcholinesterase, paraoxonase‐1, and carbonic anhydrase enzyme activities were significantly (P < .05) decreased in VCM group when compared with the control group. ZO, supplied with VCM, significantly activated some of these enzyme in all tissues. The results of this study showed that ZO regulates abnormal increases and decreases in VCM‐induced metabolic enzyme activities in all tissues.

“…In living organisms, enzymes have a crucial role and catalyse almost all chemical reactions in metabolism . Many drugs and chemicals impact metabolism at low concentrations by increasing or decreasing regular enzyme activity, especially by inhibiting specific enzymes with critical function, and they are essential drug targets . One of them is PON1.…”

Section: Resultsmentioning

confidence: 99%

The behaviour of some antihypertension drugs on human serum paraoxonase-1: an important protector enzyme against atherosclerosis

Journal of Pharmacy and Pharmacology

2019

Objectives Paraoxonase‐1 (PON1) enzyme is related to high‐density lipoprotein (HDL), which is calcium dependent. It has essential roles such as protecting LDL against oxidation and detoxification of highly toxic substances. It is a significant risk to reduce the levels of this enzyme in patients with diabetes mellitus, cardiovascular diseases, hyperthyroidism and chronic renal failure. Methods Here, it was reported that the purification of human serum PON1 using straightforward methods and determination of the interactions between some antihypertension drugs and the enzyme. Key finding It was found that these drugs exhibit potential inhibitor properties for human serum PON1 with IC50 values in the range of 131.40–369.40 μm and Ki values in the range of 56.24 ± 6.75–286.74 ± 28.28 μm. These drugs showed different inhibition mechanisms. It was determined that midodrine and nadolol were exhibited competitive inhibition, but atenolol and pindolol were exhibited non‐competitive inhibition. Conclusion Usage of these drugs would be hazardous in some cases.