The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide‐induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities

Abstract

Chrysin (CH) or 5,7-dihydroxyflavone is a flavonoid present in various plants, bee propolis, and honey. Cyclophosphamide (CYP) is a chemotherapeutic drug, which is extensively used in the treatment of multiple human malignancies. In our study, we aimed to investigate the effects of CYP and CH on some metabolic enzymes including carbonic anhydrase, aldose reductase, paraoxonase-1, α-glycosidase, acetylcholinesterase, and butyrylcholinesterase enzyme activities in the brain, heart, testis, liver, and kidney tissues of rats. Thirty-five adult male Wistar rats were used.The animals were pretreated with CH (25 and 50 mg/kg b.w.) for seven days before administering a single dose of CYP (200 mg/kg b.w.) on the seventh day. In all the tissues, the treatment of CH significantly regulated these enzyme activities in CYP-induced rats. These results showed that CH exhibited an ameliorative effect against CYP-induced brain, heart, liver, testis, and kidney toxicity.chrysin, cyclophosphamide, enzyme activities, in vivo, metabolic enzymes, rats

Synthesis, characterization, biological evaluation, and in silico studies of novel 1,3‐diaryltriazene‐substituted sulfathiazole derivatives

“…Indeed, this is a basic physiological reaction that underpins plenty of essential cellular mechanisms, like acid-base regulation, electrolyte secretion, respiration, bone resorption, calcification, and biosynthetic processes. [5][6][7][8] Therefore, many of the CAs are important drug targets for many pharmacological applications including the treatment of glaucoma, epilepsy, diuretics, and obesity, and more recently, they have been used as antitumor agents. Among the 16 different CA isoforms that have been isolated up to now, the cytosolic isoform hCA I is involved in retinal and cerebral edema, and the other physiologically related cytosolic isoform hCA II is associated with glaucoma, epilepsy, and edema.…”

The effects of zingerone against vancomycin‐induced lung, liver, kidney and testis toxicity in rats: The behavior of some metabolic enzymes

“…For instance, the effects of cyclophosphamide and chrysin on CA, AChE, and BChE enzymes activities were studied in the different tissues of rats. They found that studied all tissues, treatment of chrysin significantly regulated these enzyme activities in cyclophosphamide‐induced rats . Another study, the effects of hesperidin and sodium arsenite were studied on some metabolic enzymes administered to rats.…”

“…They found that studied all tissues, treatment of chrysin significantly regulated these enzyme activities in cyclophosphamide-induced rats. [60] Another study, the effects of hesperidin and sodium arsenite were studied on some metabolic enzymes administered to rats. They showed that studied enzymes activity was reduced given in all groups.…”

N‐Substituted pyrimidinethione and acetophenone derivatives as a new therapeutic approach in diabetes

“…[9] α-Glycosidase is a digestive enzyme that hydrolyzes carbohydrate molecules including disaccharides and starches to generate more metabolically available sugars in the course of catabolic metabolism. [10,11] Indeed, it can functionally hydrolyze carbohydrate molecules. The α-glycosidase enzyme is distinct from β-glycosidase, which cleaves glycosidic bonds.…”