Phenolic compounds oleuropein and hydroxytyrosol exert differential effects on glioma development via antioxidant defense systems

Martínez-Martos, José Manuel; Mayas, Marı́a Dolores; Carrera, Pilar; Saavedra, José Manuel Arias de; Sánchez-Agesta, Rafael; Arrazola, Marcela; Ramírez-Expósito, María Jesús

doi:10.1016/j.jff.2014.09.006

Cited by 34 publications

(29 citation statements)

References 51 publications

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“…There was high significant difference between GIIB and GIIIB where p value was <0.001. These results are concomitant with those observed by other investigators (45,46) . EVOO, a unique functional food with a major contribution to the health-promoting effects of the Mediterranean diet that contains a natural inhibitor of HT and DNA methyltransferases (DNMTs) capable of specifically and potently suppressing the functional traits of cancer stem cell (CSC) within heterogeneous cancer cell populations, might open new avenues for introducing innovations in CSC-targeted therapy based on the molecular bridge that connects metabolism and epigenetics with the state of stemness (47)(48) .…”

Section: Discussionsupporting

confidence: 93%

Efficacy of Hydroxytyrosol as Chemopreventive Agent on Induced Hamster Buccal Pouch Carcinogenesis

Abd-Alwahab

Ahmed

Zouair

2019

Al-Azhar Assiut Dental Journal

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Aim: It was to investigate the efficacy of hydroxytyrosol (HT) as chemopreventive agent on induced hamster buccal pouch (HBP) carcinogenesis. Subjects and Methods: Forty Syrian male hamsters five weeks old, weighing 80-120g, were divided into three groups. GI: 10 animals were left untreated. GII: 10 animals were painted with 0.5% 7, 12-dimethylbenz(a)anthracene (DMBA) in paraffin oil, 3 times a week, for 8 weeks (GIIA) and14 weeks (GIIB). GIII: chemoprevention group, 20 animals in which HT was taken at week before as well as during the application of DMBA, 3 times a week on alternative days, for 8 weeks (GIIIA) and14 weeks (GIIIB). HPB mucosa were excised and trimmed to 1-2 cm average size, then processed for hematoxylin and eosin (H&E) stain and Immunohistochemical (IHC) staining utilizing Bcl-2 and Bak antibodies. Results: Gross observation revealed variable changes in the treated (G (s)), (GII and GIII) compared to that observed in GI. Histopathological findings revealed variations among the treated groups. IHC results regarding Bcl-2 expression revealed variability in the area percentage throughout the used groups. GI, GIIA, GIIB, GIIIA and GIIIB were (6.77٪, 31.58٪, 68.37٪, 16.07٪, 48.81٪) respectively, while IHC results regarding Bak expression revealed variability in the area percentage throughout the used groups. GI, GIIA, GIIB, GIIIA and GIIIB were (45.32%, 28.58%, 10.38%, 19.32%, 38.72%) respectively. Conclusion: HT is considered as a promising chemopreventive agent in decrease the incidence of HBP carcinogenesis in gross observation as well as in histological examination.

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Section: Discussionsupporting

confidence: 93%

Efficacy of Hydroxytyrosol as Chemopreventive Agent on Induced Hamster Buccal Pouch Carcinogenesis

Abd-Alwahab

Ahmed

Zouair

2019

Al-Azhar Assiut Dental Journal

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“…Administration of oleuropein (125 mg/kg b.w) to ovariectomised nude mice xenografted with MCF‐7 human breast cancer cells resulted in inhibition of xenograft tumor growth and metastases and efficiently prevented both the mouse body weight loss and the peripulmonary dissemination of tumor masses (Table ). In contrast to the above studies, administration of oleuropein (0.3 mg/kg b.w) to male adult Wistar rats xenografted with C6 glioma cells did not result in inhibition of xenograft tumor growth (Table ).…”

Section: Anticancer Effects Of Oleuropein: In Vivo Animal Studiesmentioning

confidence: 68%

Anticancer effects of oleuropein

2017

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Cancer cells exhibit enhanced proliferation rate and a resistance to apoptosis. Epidemiological studies suggest that olive oil intake is associated with a reduced risk of cancer. Olive oil, olives, and olive leaves contain many polyphenols, including oleuropein. Recently, several studies have demonstrated that oleuropein inhibits proliferation and induces apoptosis in different cancer cell lines. In addition, anticancer effects of oleuropein have been seen in animal studies. These effects are associated with oleuropein's ability to modulate gene expression and activity of a variety of different signaling proteins that play a role in proliferation and apoptosis. This article summarizes the existing in vitro and in vivo studies focusing on the anticancer effects of oleuropein and its effects on key signaling molecules. © 2017 BioFactors, 43(4):517-528, 2017.

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“…e antioxidant activities of olive leaf extracts have been ascribed to the presence of phenolics such as oleuropein, luteolin, and hydroxytyrosol [18]. For example, oleuropein, the main component of olive leaf extract, exhibits antihypotensive, anti-inflammatory, and strong antioxidant activities [19][20][21]. Consequently, there is a growing interest in recovering phenolic compounds from olive leaves [22].…”

Section: Introductionmentioning

confidence: 99%

Journal of Food Quality Evaluation of Effect of Extraction Solvent on Selected Properties of Olive Leaf Extract

Cho

Kim

Lee

et al. 2020

Journal of Food Quality

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The quest for natural preservatives and functional foods with health benefits has seen an increasing demand for natural products having therapeutic value. Herein, we investigated the influence of ethanol, methanol, acetone (50%, 70%, and 90% v/v), and distilled water on selected properties of olive leaf extract and determined the yield, total phenolic content (TPC), antioxidant activity, and antimicrobial activity. Extracts were analyzed for their oleuropein, hydroxytyrosol, and tyrosol contents by high-performance liquid chromatography (HPLC). The highest extraction yield of 20.41% was obtained when using 90 vol% methanol, while the highest total polyphenol contents of 232 and 231 mggallic-acid-equivalent/100 g were obtained for 90 vol% methanol and 90 vol% ethanol, respectively. Antioxidant activity was determined using the α,α-diphenyl-β-picrylhydrazyl (DPPH) radical scavenging assay, by determining the ferric reducing antioxidant power (FRAP), and using the Fe2+-chelating activity assay, which provided the highest values when 90 vol% methanol was used (33.84%, 0.75, and 12.91%, respectively). HPLC analysis showed that the highest oleuropein contents corresponded to the extracts obtained using 90 and 70 vol% methanol (26.10 ± 0.20 and 24.92 ± 1.22 g/L, respectively), and the highest antimicrobial activity was observed for 90 vol% methanol and distilled water. Olive leaf extracts using 90 vol% methanol had high levels of polyphenols and were highly antioxidant and antimicrobial. The results of this study facilitate the commercial applications of natural extracts with antioxidant and antibacterial activities and are expected to establish a foundation for further optimization studies.

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Phenolic compounds oleuropein and hydroxytyrosol exert differential effects on glioma development via antioxidant defense systems

Cited by 34 publications

References 51 publications

Efficacy of Hydroxytyrosol as Chemopreventive Agent on Induced Hamster Buccal Pouch Carcinogenesis

Efficacy of Hydroxytyrosol as Chemopreventive Agent on Induced Hamster Buccal Pouch Carcinogenesis

Anticancer effects of oleuropein

Journal of Food Quality Evaluation of Effect of Extraction Solvent on Selected Properties of Olive Leaf Extract

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