Anticancer effects of oleuropein

Shamshoum, Hesham; Vlavcheski, Filip; Tsiani, Evangelia

doi:10.1002/biof.1366

Cited by 83 publications

(71 citation statements)

References 81 publications

(141 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Given our previous evidence for the protective role of Ole in neurodegenerative and cardiovascular diseases [40][41][42][43], we have decided to investigate whether Ole might exert some role in melanoma treatment. The existing studies indicate that Ole express a well-demonstrated protective role against many types of cancer [22]. Most of the studies have investigated the anticancer effects of Ole on breast cancer, disclosing that the polyphenol may not only decrease cell viability and proliferation [44] and synergize with Doxorubicin in in vitro and in vivo model [25,45], but also may reverse resistance toward the chemotherapeutic agent, Trastuzumab [46].…”

Section: Discussionmentioning

confidence: 99%

“…Ole has been reported to have many pharmacological properties, among which antioxidant, anti-inflammatory, cardioprotective, neuroprotective and hepatoprotective [20,21]. Recently accumulating in vitro and in vivo experiments together with epidemiological and clinical data, have provided support to the anti-tumor properties of Ole toward different tumor histotypes, such as breast, colon and lung cancer [22,23]. What is of translational importance, Ole was found to be a powerful sensitizer of Doxorubicin-mediated killing of prostate and breast cancer cells [24,25].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oleuropein, the Main Polyphenol of <em>Olea europaea </em>Leaf Extract, Has an Anti Cancer Effect on Human BRAF Melanoma Cells and Potentiates the Cytotoxicity of Current Chemotherapies

Ruzzolini¹,

Peppicelli²,

Andreucci³

et al. 2018

Preprint

View full text Add to dashboard Cite

Oleuropein (Ole), a secoiridoid glucoside present in Olea europaea leaves, gained the interest of many scientists thanks to its several biological properties, including the anticancer one. We verified whether Ole might potentiate cytotoxicity of conventional drugs used to treat melanoma, disclosing new potential therapeutic strategy. We tested the cytotoxic action of Ole alone or in combination with chemotherapeutics on A375 human melanoma cells. We found that Ole was able, at a dose of 500 μM, to stimulate apoptosis in melanoma cells, while at a non-toxic dose of 250 μM, it affected cell proliferation and induced the downregulation of pAKT/pS6 pathway. 250 μM Ole did not potentiate the effect of Vemurafenib (PLX4032), but it succeeded in increase the cytotoxic effect of Dacarbazine (DTIC). The mayor effect was found in the association between Ole and Everolimus (RAD001), also on PLX4032-resistant BRAF melanoma cells, possibly cooperating in the inhibition of pAKT/pS6 pathway. Of interest, an olive leaf extract enriched in equimolar Ole was more effective and able to further improve DTIC and, particularly, RAD001 efficacy on BRAF melanoma cells than Ole alone. Therefore, Ole represents a natural product able to potentiate a wide array of chemotherapeutics against BRAF melanoma cells affecting pAKT/pS6 pathway.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oleuropein, the Main Polyphenol of <em>Olea europaea </em>Leaf Extract, Has an Anti Cancer Effect on Human BRAF Melanoma Cells and Potentiates the Cytotoxicity of Current Chemotherapies

Ruzzolini¹,

Peppicelli²,

Andreucci³

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…In addition, anticancer effects of oleuropein have been seen in animal studies. These effects are associated with oleuropein's ability to modulate gene expression and activity of a variety of different signalling proteins that play a role in proliferation and apoptosis .…”

Section: Hesham Shamshoum Filip Vlavcheski Evangelia Tsianimentioning

confidence: 99%

Issue Highlights

2017

BioFactors

View full text Add to dashboard Cite

“…The most widely investigated olive phenolic compounds include, oleuropein, hydroxytyrosol, tyrosol and oleocanthal (Figure 1). The potential beneficial health effects and cellular and molecular mechanisms of oleuropein, hydroxytyrosol and tyrosol have been reviewed extensively (22–29). Oleocanthal also represents an important phenolic compound in extra-VOO, which has been shown to possess potent antioxidant and anti-inflammatory effects, at least in part, through non-specific inhibition of cyclooxygenase-1 and -2 enzymes (30, 31).…”

Section: Introductionmentioning

confidence: 99%

OliveNet™: a comprehensive library of compounds fromOlea europaea

Bonvino

Liang

McCord³

et al. 2018

Database

View full text Add to dashboard Cite

Accumulated epidemiological, clinical and experimental evidence has indicated the beneficial health effects of the Mediterranean diet, which is typified by the consumption of virgin olive oil (VOO) as a main source of dietary fat. At the cellular level, compounds derived from various olive (Olea europaea), matrices, have demonstrated potent antioxidant and anti-inflammatory effects, which are thought to account, at least in part, for their biological effects. Research efforts are expanding into the characterization of compounds derived from Olea europaea, however, the considerable diversity and complexity of the vast array of chemical compounds have made their precise identification and quantification challenging. As such, only a relatively small subset of olive-derived compounds has been explored for their biological activity and potential health effects to date. Although there is adequate information describing the identification or isolation of olive-derived compounds, these are not easily searchable, especially when attempting to acquire chemical or biological properties. Therefore, we have created the OliveNet™ database containing a comprehensive catalogue of compounds identified from matrices of the olive, including the fruit, leaf and VOO, as well as in the wastewater and pomace accrued during oil production. From a total of 752 compounds, chemical analysis was sufficient for 676 individual compounds, which have been included in the database. The database is curated and comprehensively referenced containing information for the 676 compounds, which are divided into 13 main classes and 47 subclasses. Importantly, with respect to current research trends, the database includes 222 olive phenolics, which are divided into 13 subclasses. To our knowledge, OliveNet™ is currently the only curated open access database with a comprehensive collection of compounds associated with Olea europaea.Database URL: https://www.mccordresearch.com.au

show abstract

Anticancer effects of oleuropein

Cited by 83 publications

References 81 publications

Oleuropein, the Main Polyphenol of <em>Olea europaea </em>Leaf Extract, Has an Anti Cancer Effect on Human BRAF Melanoma Cells and Potentiates the Cytotoxicity of Current Chemotherapies

Oleuropein, the Main Polyphenol of <em>Olea europaea </em>Leaf Extract, Has an Anti Cancer Effect on Human BRAF Melanoma Cells and Potentiates the Cytotoxicity of Current Chemotherapies

Issue Highlights

OliveNet™: a comprehensive library of compounds fromOlea europaea

Contact Info

Product

Resources

About