Phenolic compounds of Artemisia adamsii

Chemesova, I. I.; Belenovskaya, L. M.; Nadezhina, T. P.

doi:10.1007/bf00579783

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(2 citation statements)

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“…Moreover, for the first time in A. gmelinii species, luteolin, rutin, isorhamnetin and scopolin were identified, even though these substances were previously determined in other species of Artemisia [27–29]. The presence of apigenin, scopoletin, chlorogenic acids and two dicaffeoylquinic acid isomers have also previously been reported [12, 13, 30]. Additionally it is worth to highlight that low level of thujone was determined in the tested extract so there should be no potential influence of the activity as well as no toxicity towards the human.…”

Section: Discussionmentioning

confidence: 90%

“…Phytochemical studies concerning phytochemical composition of A. gmelini are rather partial. So far 1,8 - cineol (21–40%), camphora (10–31%), borneol (4–17%) were detected as main compounds in essential oil [11], as well as polyphenolic components such as scopoletin, chlorogenic acid, 4′,7- di-O-methyl-apigenin, acacetin and 4′,5,7 - trihydroxy-3′,6-dimethoxyflavon [12], caffeic acid, 4-O-caffeoylquinic acid, luteolin-7-O-glucoside, and apigenin-7-O-glucoside, 3,5-O-dicaffeoylquinic acid and its ethyl ester derivatives [13] were indicated as dominant compounds of Artemisia gmelinii .…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical composition of wormwood (Artemisia gmelinii) extracts in respect of their antimicrobial activity

Mamatova

Korona-Głowniak

Skalicka-Woźniak

et al. 2019

BMC Complement Altern Med

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BackgroundExtracts from medicinal plants with phytochemicals with known antimicrobial properties can be an effective adjunct in the complex treatment of infectious diseases. This study aimed to evaluate the antimicrobial activity of wormwood extracts collected in Kazakhstan (Artemisia gmelinii Weber ex Stechm.), along with their phytochemical analysis.MethodsThe ethanolic and chloroform extracts were subjected to HPLC combined with quadrupole time-of-flight mass spectrometry method. For quantitative assessment of antimicrobial activity, minimal inhibitory concentration (MIC) of the tested extracts was determined by micro-dilution broth method for the panel of the reference microorganisms. Minimal bactericidal concentration (MBC) or minimal fungicidal concentration (MFC) were also determined.ResultsLC/MS analysis showed the presence of 13 compounds in the tested extracts, including flavonoids: apigenin, luteolin, rutin, two O-methylated flavonols (isorhamnetin, rhamnazine), coumarin compounds (umbelliferone, scopoletin and scopolin (scopoletin 7-glucoside), 3-hydroxycoumarin and 4-hydroxycoumarin), chlorogenic acid and two dicaffeoylquinic acid isomers. Quantitative HPLC analysis showed that umbelliferone was dominant in the chloroform extract while chlorogenic acid was identified as a main compound in the ethanolic extract. The antibacterial and antifungal activity of chloroform and ethanolic extracts was comparable. The most sensitive were the Gram-positive bacteria represented by staphylococci, Micrococcus luteus and Bacillus spp. (MIC = 1.25–5 mg/ml) and yeasts represented by Candida spp. (MIC = 2.5–5 mg/ml), irrespective of the assayed extract.ConclusionsExtracts of wormwood Artemisia gmelinii have shown a wide spectrum of antibacterial and antifungal activity. Luteolin, rutin, isorhamnetin and scopolin were identified in A. gmelinii species for the first time. The determining of the most potential compounds of Artemisia gmelinii can be used to develop effective antibacterial and antifungal agents.

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