Phenolic compounds from<i>Scorzonera latifolia</i>(Fisch. &amp; Mey.) DC.

Sarı, Aynur

doi:10.1080/14786419.2010.533666

Cited by 20 publications

(8 citation statements)

References 24 publications

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“…The molecular formula was determined as Scorzonera parviflora has been evaluated for their inhibitory activities of TNF-α and IL-1β production, and NF-κB nuclear translocation in THP-1 macrophages and HPLC analysis revealed chlorogenic acid was present in all tested extracts [32]. Isolation of caffeic acid derivatives was mentioned from the subaerial parts of S. latifolia [33].…”

Section: Resultsmentioning

confidence: 99%

New chlorogenic acid derivatives and triterpenoids from Scorzonera aucheriana

Erik¹,

Çoşkunçelebi²,

Makbul³

et al. 2021

Turk J Chem

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Chromatographic separation of n-hexane and ethyl acetate fraction of a crude methanol extract obtained from aerial parts of the Scorzonera aucheriana DC collected from Sivas province of Turkey yielded nine natural compounds, including two new 3caffeoyl-quinic acid analogs (1-2), and one new taraxasterol oleate (3), as well as six known triterpenoids taraxasterol (4), taraxasterol acetate (5), ptiloepoxide (6), lupeol (7), lupeol acetate (8), and β-sitosterol (9) were characterized. The structures of the 2 isolated compounds were elucidated on the basis of NMR (1 H, 13 C, COSY, HMBC, HSQC, and TOCSY), UV, FT-IR and LC-Q-TOF-MS spectrometric data.

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Section: Resultsmentioning

confidence: 99%

New chlorogenic acid derivatives and triterpenoids from Scorzonera aucheriana

Erik¹,

Çoşkunçelebi²,

Makbul³

et al. 2021

Turk J Chem

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“…According to the current study Scorzonera root extracts displayed hepatoprotective activities probably due to their chlorogenic acid contents. Derivatives of chlorogenic acid 3,4 and 3,5 dicaffeoylquinic acids were also reported to have protective activity in CCl 4 induced hepatotoxicity [26] which have also been isolated from some Scorzonera species previously [11,12] .…”

Section: Resultsmentioning

confidence: 99%

“…Antiinflammatory, antioxidant, and wound healing activities have also been reported [6][7][8][9] . Phytochemical analyses revealed that S. latifolia roots contained taraxasteryl myristate, taraxasteryl acetate, motiol, 3-β-hydroxy fern-8 en-7-one acetate, urs-12-en-11-one-3-acetyl, 3-β-hydroxyfern-7-en-6-one-acetate, olean-12-en-11-one-3-acetyl, fern-7-en-3-β-one, leucodin, β-sitosterol [3,5,10] , chlorogenic acid, chlorogenic acid methyl ester, 1,5-dicaffeoyl quinic acid, 3,5-dicaffeoyl quinic acid, methylester of 3,5-dicaffeoyl quinic acid, hydrangenol-8-O-β-glucoside, hydrangenol-4'-O-β-glucoside, scorzotomentosin-4'-O-β-glucoside and a new isocoumarine derivative [11] as well as scorzoveratrin 4'-O-β-glucoside, scorzoveratrin, scorzoveratrozit, 4,5-dicaffeoylquinic acid, 4,5-dicaffeoylquinic acid methyl ester and caffeic acid [12] . Scorzotomentosin, scorzotomentosin-4'-O-β-glucoside, scorzophtalide, scorzoerzincanin, hydrangenol, hydrangenol-4'-O-β-glucoside, hydramacrophyllol A and B have been isolated from S. tomentosa roots previously [13] .…”

Section: Research Papermentioning

confidence: 99%

Preclinical Evaluation of Scorzonera sp. Root Extracts and Major Compounds Against Acute Hepatotoxicity Induced by Carbon Tetrachloride

Acikara¹,

Yigitbasi²,

Sakul³

et al. 2017

pharmaceutical-sciences

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Evaluation of hepatoprotective activities of Scorzonera roots and their major compounds, was aimed in current study. Scorzonera latifolia, S. tomentosa, S. mollis ssp. szowitsii, S. parviflora and S. cana var. jacquiniana roots, methanol-water (80:20) extracts together with chlorogenic acid, scorzotomentosin-4'-O-β-glucoside, hydrangenol-8-O-β-glucoside as major compounds isolated from S. latifolia roots were tested for their hepatoprotective activities. Sprague Dawley rats were used for experiment and hepatotoxicity was induced by carbon tetrachloride. Aspartate aminotransferase and alanine aminotransferase levels were measured and all results were confirmed by histopathological examination. Plasma aspartate aminotransferase and alanine aminotransferase levels of examined groups were not significant when compared to carbon tetrachloride-treated groups. However histopathological results have revealed that all tested groups have less damage when compared to carbon tetrachloride group except scorzotomentosin-4'-O-β-glucoside and hydrangenol-8-O-β-glucoside groups. Scorzonera species displayed moderate hepatoprotective activities against carbon tetrachloride induced acute toxicity. Chlorogenic acid, among tested compounds exhibited higher activity than all tested Scorzonera species as well as other isolated compounds. Therefore chlorogenic acid could be suggested as responsible compound.

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“…[18][19][20][21] S. latifolia roots contain terpenes; taraxasteryl myristate, taraxasteryl acetate, motiol, 3-β-hydroxy fern-8 en-7-one acetate, urs-12-en-11-one-3-acetyl, 3-β-hydroxy-fern-7-en-6-one-acetate, olean-12-en-11-one-3-acetyl, fern-7-en-3-β-one, leucodin, β-sitosterol [22][23][24] , phenolic compounds; chlorogenic acid, chlorogenic acid methyl ester, 1,5-dicaffeoyl quinic acid, 3,5-dicaffeoyl quinic acid, methylester of 3,5-dicaffeoyl quinic acid, hydrangenol-8-Oglucoside, hydrangenol-4'-O-glucoside, scorzotomentosin-4'-O-glucoside and a new isocoumarine derivative 25 as well as scorzoveratrin 4'-O-β-glucoside, scorzoveratrin, scorzoveratrozit, 4,5-dicaffeoylquinic acid, 4,5-dicaffeoylquinic acid methyl ester and caffeic acid. 26 Aerial parts of the plant have been reported to contain phenolics which were identified as quercetin-3-O-β-glucoside, hyperoside, hydrangenol-8-Oglucoside, swertisin, 7-methylisoorientin, 4,5-O-dicaffeoylquinic acid, 3,5-di-O-caffeoyl-quinic acid and chlorogenic acid. 27 In the current study, three samples of S. latifolia Fisc.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antioxidant Activities and Phenolic Compounds of <i>Scorzonera latifolia</i> (Fisch. & Mey.) DC. Collected from Different Geographic Origins in Turkey

Açıkara¹,

Öz²,

Bakar³

et al. 2017

tjps

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Amaç: Bitkilerin kimyasal içeriği pek çok parametreden etkilenmektedir. Bitkinin toplandığı bölge içerdiği fenolik bileşiklerin kompozisyonunu ve dolayısıyla aktivitelerini etkilemektedir. Bu çalışmada, Türkiye'nin farklı bölgelerinden toplanan Scorzonera latifolia (Fisch & Mey.) DC. kök ve toprak üstü kısımlarının antioksidan etki potansiyallerinin ölçülmesi amaçlanmıştır. Gereç ve Yöntemler: Test edilen ekstrelerin antioksidan kapasiteleri 1,1-difenil-2-pikrilhidrazil (DPPH) radikal süpürücü etkileri ve malondialdehit (MDA) seviyesi üzerine etkilerinin ölçülmesiyle tespit edilmiştir. Araştırma konusu olan örneklerin kimyasal içeriğindeki değişiklikleri incelemek için kalitatif ve kantitatif yüksek performanslı sıvı kromatografisi analizleri yapılmıştır. Bulgular: Kantitatif analiz sonuçları bitkilerde tespit edilen klorojenik asit ve hiperozit miktarlarının toplandığı bölgeye göre değiştiğini göstermiştir. S. latifolia Kars örneğinin diğer örneklere göre daha yüksek hiperozit (652.32±2.48 μg/g) ve klorojenik asit (1246.78±3.20 μg/g) içeriğine sahip olduğunu ortaya koymuştur. En yüksek DPPH radikal süpürücü etki 1.036 mg/mL IC 50 değeri ile S. latifolia Kayseri örneğinde gözlenmiştir. En düşük MDA seviyesi ise S. latifolia Bayburt kök örneğinde (4.41 nmol/mL) belirlenmiştir. Sonuç: Antioksidan aktivite sonuçları değerlendirildiğinde, farklı lokasyonlardan toplanan örnekler arasında, S. latifolia Kars kök örneği haricinde belirgin bir farklılık tespit edilememiştir. Anahtar kelimeler: DPPH, serbest radikal süpürücü aktivite, yüksek performanslı sıvı kromatografisi, MDA, Scorzonera latifolia Objectives: The chemical composition of plants is considered to be affected by many parameters. Therefore, the region where the samples are collected is likely to have an influence on the composition of phenolic compounds, so that their biological activities. In the present study, evaluation of antioxidant activity potentials of Scorzonera latifolia (Fisch. & Mey.) DC. aerial parts and roots, which were collected from different regions of Turkey, was aimed. Materials and Methods: 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method and measurement of malondialdehyde (MDA) levels were used for determining antioxidant capacities of the tested extracts. In order to observe variations in the chemical composition of the investigated samples qualitatively as well as quantitatively, high performance liquid chromatography analyses were performed. Results: Quantitative analysis showed that the amounts of chlorogenic acid and hyperoside in plants vary according to the regions where the samples were collected. As a result aerial parts of the S. latifolia collected from the Kars region have found to contain higher amount of chlorogenic acid (1246.78±3.20 μg/g) as well as hyperoside (652.32±2.48 μg/g) than other samples. The highest DPPH radical scavenging activity was determined with the IC 50 value of 1.036 mg/mL for S. latifolia aerial parts of Kayseri sample. MDA level was detected as the lowest with treatment of S. latifolia...

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Phenolic compounds fromScorzonera latifolia(Fisch. & Mey.) DC.

Cited by 20 publications

References 24 publications

New chlorogenic acid derivatives and triterpenoids from Scorzonera aucheriana

New chlorogenic acid derivatives and triterpenoids from Scorzonera aucheriana

Preclinical Evaluation of Scorzonera sp. Root Extracts and Major Compounds Against Acute Hepatotoxicity Induced by Carbon Tetrachloride

Evaluation of Antioxidant Activities and Phenolic Compounds of <i>Scorzonera latifolia</i> (Fisch. & Mey.) DC. Collected from Different Geographic Origins in Turkey

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