Phenolic compounds fromNicotiana tabacumand their biological activities

Abstract

Three new phenolic compounds, nicotphenols A-C (1-3), together with 14 known phenols (4-17), were isolated from the leaves of Nicotiana tabacum. Their structures were established by means of spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1-3 were tested for their anti-HIV-1 activities and cytotoxicities. They all showed significant cytotoxic abilities and modest anti-HIV-1 activities, respectively.

Discovery of UDP-Glycosyltransferases and BAHD-Acyltransferases Involved in the Biosynthesis of the Antidiabetic Plant Metabolite Montbretin A

“…Tobacco leaves have been reported to contain various kaempferol glycosides (Chen et al, 2012), suggesting that kaempferol may be available as a flavonol substrate. We tested leaves that expressed 35S pro :eGFP, 35S pro :UGT77B2, or 35S pro :UGT77B2 + 35S pro :UGT709G2 for kaempferol glycosides (Figure 8).…”

Antiviral isocoumarins from the roots and stems of Nicotiana tabacum

“…In addition, N. tabacum is also used as insecticides, anesthetics, diaphoretics, sedatives, and emetic agents in Chinese folklore medicines because of its containing many useful chemical compounds (Kuang and Lu, 2005;Rodgman and Perfetti, 2008). Previous investigation of this species led to the discovery of a number of new compounds that showed various bioactivities, such as anti-HIV-1, anti-TMV, and cytotoxicity by our groups (Tan et al, 2011;Chen et al, 2012aChen et al, ,b, 2013Gao et al, 2012;Mou et al, 2012). In continuing efforts to the phytochemistry research on the roots and stems of K326 (a variety of N. tabacum) led to the isolation of three new isocoumarin derivatives (1-3) and three known phenolic compounds (4-6) ( Fig.…”

Biphenyls from Nicotiana tabacum and their anti-tobacco mosaic virus

“…Previous investigation of this species led to the discovery of a number of new compounds by our groups, which were found to exhibit various bioactivities, such as anti-HIV-1, anti-TMV, and cytotoxicity [4][5][6][7][8][9]. In continuing efforts to utilize N. tabacum and identify bioactive natural products, the phytochemical investigation of the leaves of Honghua Dajinyuan (a variety of N. tabacum) led to the isolation of five new (1)(2)(3)(4)(5) and five known (6-10) biphenyls, of which compound 1 possessed a seldom reported 6-carbons unit (C-7, C-8, C-9, C-10, C-11, C-12) in biphenyls. This paper deals with the isolation, structural elucidation, and anti-TMV activity of these compounds (Fig.…”