Phenolic Compounds from Centaurea horrida L Growing in Lebanon

Boukhary, Rima; Aboul-Ela, Maha; Al-Hanbali, Othman; El-Lakany, Abdalla

doi:10.25258/ijpapr.v9i1.8030

Cited by 4 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 1 H-NMR spectrum (400 MHz, DMSO-d 6 ) showed d 10.73 (s, 1H), 9.49 (s, 1H), 9.26 (s, 1H), 9.03 (s, 1H), 7.90 (d, J = 9.6 Hz, 1H), 7.67 (d, J = 1.8 Hz, 1H), 7.52 (dd, J = 8.5, 2.1 Hz, 1H), and 6.91-6.85 (m, 3H)] ( Figure S2 ), and the 13 C-NMR spectrum (100, 125 MHz, DMSO-d 6 ) was 102.19, 114.59, 115.03, 115.31, 115.94, 120.00, 122.86, 126.85, 137.56, 145.41, 147.62, 156.65, 162.63, and 172.34 ( Figure S3 ). Its NMR data were identical to those of prior research [ 22 , 23 ]. Therefore, fraction peak number 2 was confirmed to be 3,3’,4’,7-tetrahydroxy flavones (fisetin) based on the peaks showing 1 H-NMR and 13 C-NMR spectra.…”

Section: Resultssupporting

confidence: 77%

See 1 more Smart Citation

Isolation and Identification of Fisetin: An Antioxidative Compound Obtained from Rhus verniciflua Seeds

Kim

Huh

2022

Molecules

View full text Add to dashboard Cite

The goal of this study was to provide basic data for the development of functional food and health materials for Rhus verniciflua (R. verniciflua) seeds. We investigated an antioxidative compound obtained from these seeds. Solvent fractionation was carried out on a 50%-ethanol extract of the seeds. The DPPH and ABTS radical-scavenging activity and superoxide dismutase (SOD) activity were measured, and high antioxidant activity was seen in the ethyl acetate fraction. The antioxidant compounds in the ethyl acetate fraction were isolated using silica-gel column chromatography by adjusting the solvent between chloroform and methanol. Fraction numbers 2–7 showed activity of more than 50%. Next, primary column chromatography was used to mix and concentrate the fractions that demonstrated antioxidant activity. The fractions were then subjected to secondary column chromatography to obtain subfraction 4, which showed high antioxidant activity. The separation of subfraction 4 was then performed using high-performance liquid chromatography (HPLC). Three peaks were identified and peak number 2 was judged to be the primary antioxidative compound, which was then isolated by pure separation. Finally, the purified subfraction peak number 2 was identified as a fisetin compound by liquid chromatography–mass spectrometry (LC–MS), nuclear magnetic resonance (NMR), and HPLC.

show abstract

Section: Resultssupporting

confidence: 77%

“…The S3). Its NMR data were identical to those of prior research [22,23]. Therefore, fraction peak number 2 was confirmed to be 3,3',4',7tetrahydroxy flavones (fisetin) based on the peaks showing 1 H-NMR and 13 C-NMR spectra.…”

Section: Identification Of Fraction Peak Number 2's Substances By Liq...supporting

confidence: 80%

Isolation and Identification of Fisetin: An Antioxidative Compound Obtained from Rhus verniciflua Seeds

Kim

Huh

2022

Molecules

View full text Add to dashboard Cite

show abstract

“…(2), 23 β-sitosterol-3-O-βd-glucoside (3), 24 (−)-eriodictyol (4), 25 (−)-dihydroquercetin (5), 26 (−)-fustin (6), 27 and fisetin (7). 28 Compounds 4 to 6 were previously isolated from the twigs of this plant. 6 Glutacoside (1) was isolated as a white powder with melting points of 142°C to 143°C.…”

Section: Structure Elucidationmentioning

confidence: 99%

“…These compounds were identified on the basis of spectroscopic methods and comparison of the data with the literature values as 3,4,5-trime thoxyphenol- 1-O-βd-glucopyranoside (2), 23 β-sitosterol-3-O-βd-glucoside (3), 24 (−)-eriodictyol (4), 25 (−)-dihydroquercetin (5), 26 (−)-fustin (6), 27 and fisetin (7). 28 Compounds 4 to 6 were previously isolated from the twigs of this plant. 6 Glutacoside (1) was isolated as a white powder with melting points of 142°C to 143°C.…”

Section: Structure Elucidationmentioning

confidence: 99%

Histone Deacetylase Inhibitors and Antioxidants From the Root of Gluta usitata

Kumboonma

Saenglee

Senawong

et al. 2019

Natural Product Communications

View full text Add to dashboard Cite

A new glycoside, glutacoside (1), as well as 6 known compounds was isolated and identified from the root of Gluta usitata. Their structures were determined by Infrared spectroscopy, Mass spectroscopy, and 1-Dimensional and 2-dimensional nuclear magnetic resonance spectroscopy data. The histone deacetylase (HDAC) inhibitory and antioxidant activities of the obtained compounds were evaluated. Molecular docking experiments of the selected compound with representatives of class I (HDAC2 and HDAC8) and class II (HDAC4 and HDAC7) HDAC isoforms displayed potential isoform-selective HDAC inhibitors. Molecular docking data showed consistent results to the in vitro experiments with the highest potency against HDAC8. The docking studies suggested that the phenolic and carbonyl group can be favorably accommodated at the gorge region of the binding site. Furthermore, the phenolic groups also acted as major roles for antioxidant activities.

show abstract

A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

Fattaheian-Dehkordi

Hojjatifard

Saeedi

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. Diabetes mellitus (DM) is a long-life metabolic disorder, characterized by high blood glucose levels. The hyperglycemic condition generally leads to irreversible nerve injury and vascular damage. Among different types of diabetes, type 2 is more common and has spread all over the world. Although various therapeutic approaches have been developed to control type 2 DM, regulating blood glucose levels has still remained a controversial challenge for patients. Also, most prescription drugs cause different side effects, such as gastrointestinal disorders. Thus, developing novel and efficient antidiabetic agents possessing fewer adverse effects is in high demand. Method. The literature was comprehensively surveyed via search engines such as Google Scholar, PubMed, and Scopus using appropriate keywords. Results. Medicinal plants, both extracts and isolated active components, have played a significant role in controlling the blood glucose levels. Good-to-excellent results documented in the literature have made them a precious origin for developing and designing drugs and supplements against DM. Centaurea spp. have been traditionally used for controlling high blood glucose levels. Also, the antidiabetic properties of different species of Centaurea have been confirmed in recent studies through in vitro assays as well as in vivo experiments. Conclusion. Potent results encouraged us to review their efficacy to open a new horizon for development of herbal antidiabetic agents.

show abstract

Phenolic Compounds from Centaurea horrida L Growing in Lebanon

Cited by 4 publications

References 0 publications

Isolation and Identification of Fisetin: An Antioxidative Compound Obtained from Rhus verniciflua Seeds

Isolation and Identification of Fisetin: An Antioxidative Compound Obtained from Rhus verniciflua Seeds

Histone Deacetylase Inhibitors and Antioxidants From the Root of Gluta usitata

A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

Contact Info

Product

Resources

About