Phenolic Compounds from Artemisia iwayomogi and Their Effects on Osteoblastic MC3T3-E1 Cells

Ding, Yan; Liang, Chun; Yang, Seo Young; Chan, J.K.-M.; Choi, Eun Mi; Kim, Jeong Ah; Kim, Young Ho

doi:10.1248/bpb.33.1448

Cited by 19 publications

(12 citation statements)

References 22 publications

(16 reference statements)

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“…Of these, scopolin (1.21%) was the most abundant, followed by scopoletin (0.38%) and acetophenone glycoside (0.26%). In addition, the scopolin content of the AI extract was higher in our study than that observed by Kim et al (0.49% w/w) and Ding et al (0.2% w/w) [43, 45]. This difference may be due to the differing extraction and isolation methods as well as differences in plant material [43, 45].…”

Section: Discussioncontrasting

confidence: 72%

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Artemisia iwayomogiExtract Attenuates High-Fat Diet-Induced Obesity by Decreasing the Expression of Genes Associated with Adipogenesis in Mice

Choi

Yanagawa

Kim

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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The objective of the present study was to determine whether Artemisia iwayomogi (AI) extract reduces visceral fat accumulation and obesity-related biomarkers in mice fed a high-fat diet (HFD), and if so, whether these effects are exerted by modulation of the expression of genes associated with adipogenesis and inflammation. AI extract supplementation for 11 weeks significantly prevented HFD-induced increments in body weight, visceral adiposity, adipocyte hypertrophy, and plasma levels of lipids and leptin. Additionally, AI extract supplementation resulted in downregulation of adipogenic transcription factors (PPARγ2 and C/EBPα) and their target genes (CD36, aP2, and FAS) in epididymal adipose tissue compared to the HFD alone. The AI extract effectively reversed the HFD-induced elevations in plasma glucose and insulin levels and the homeostasis model assessment of insulin resistance index. Furthermore, the extract significantly decreased gene expression of proinflammatory cytokines (TNFα, MCP1, IL-6, IFNα, and INFβ) in epididymal adipose tissue and reduced plasma levels of TNFα and MCP1 as compared to HFD alone. In conclusion, these results suggest that AI extract may prevent HFD-induced obesity and metabolic disorders, probably by downregulating the expression of genes related to adipogenesis and inflammation in visceral adipose tissue.

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Section: Discussioncontrasting

confidence: 72%

“…Several studies have demonstrated that AI contains flavonoids such as genkwanin and jaceosidin [43], essential oils, including eugenol and 1,8-cineole [44], and coumarin compounds such as scopoletin and scopolin [43, 45]. In addition, scopoletin has been used as a standard compound for the verification and identification of AI [46, 47].…”

Section: Discussionmentioning

confidence: 99%

Artemisia iwayomogiExtract Attenuates High-Fat Diet-Induced Obesity by Decreasing the Expression of Genes Associated with Adipogenesis in Mice

Choi

Yanagawa

Kim

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…It has been pharmacologically reported mainly by Korean researchers that A. iwayomogi inhibits adipogenesis, osteoporosis, hepatic fibrosis, allergy, and inflammation Ding et al, 2010;Han et al, 2012;Shin et al, 2006). In particular, scopoletin and scopolin inhibit osteoporosis by scavenging reactive oxygen species (Lee et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…In particular, scopoletin and scopolin inhibit osteoporosis by scavenging reactive oxygen species (Lee et al, 2013). As constituents of A. iwayomogi, the isolation of coumarins and aceophenones, in addition to potent peroxynitrite scavengers such as chlorogenic acid, genkwanin and scopoletin, was reported (Ding et al, 2010;Kim et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous quantification and validation of new peroxynitrite scavengers fromArtemisia iwayomogi

Nugroho

Lim

Karki

et al. 2014

Pharmaceutical Biology

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Context: Artemisia iwayomogi Kitamura (Compositae) has been very widely used for the treatment of acute or chronic hepatitis, jaundice, and gastritis. In the course of our continuing efforts to identify and quantify peroxynitrite scavengers from Compositae plants, A. iwayomogi was used in this study. Objective: The present study was aimed to identify and quantify the peroxynitrite scavengers of A. iwayomogi. Materials and methods: Silica gel and ODS were used for column chromatography. The isolated compounds were quantified using an HPLC equipped with a Capcell Pak C18 column (5 mm, 250 mm Â 4.6 mm i.d.), and the method was validated for the quality control. Peroxynitrite (ONOO À )-scavenging activities of the compounds and extracts were evaluated on the measurement of highly fluorescent rhodamine 123 converted from non-fluorescent dihydrorhodamine (DHR)-123 under the presence of peroxynitrite. Results: Based on the spectroscopic evidences, a new compound, 2 00 -O-caffeoylrutin (2 00 -O-trans-caffeic acid ester of quercetin 3-O-a-L-rhamnopyranosyl(1 ! 6)-b-D-glucopyranoside) was isolated and determined together with patuletin 3-O-glucoside, scopolin, scopoletin, rutin, 3,4-dicaffeoylquinic acid, and chlorogenic acid. All of them were potent peroxynitrite scavengers (IC 50 1.88 mg/mL). Discussion and conclusion: The peroxynitrite scavengers were mainly distributed in the EtOAc fraction rather than the ether and BuOH fractions. The 70% MeOH extract exhibited a high peroxynitrite-scavenging activity. Through the validation, the present HPLC method was verified to be sufficiently sensitive, accurate, precise, and stable. Therefore, this method can be used for the quality control of A. iwayomogi.

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“…They seem to be mostly confined to the genus Artemisia [20]. Within the coumarins reported from the genus Artemisia to date, the 7,8-dioxygenated coumarins seem to be quite common, and might be utilized as a chemotaxonomic marker for this genus [21]. Similarly, the flavonoid glycosides 5, 6, and 7, and other isolated compounds 8 and 9 have not been isolated from A. armeniaca before, but they seem to occur in other Artemisia species [22].…”

mentioning

confidence: 98%

Armenin and Isoarmenin – Two Prenylated Coumarins from the Aerial Parts of Artemisia armeniaca

Mojarrab

Delazar

Moghadam

et al. 2011

Chemistry & Biodiversity

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The reversed-phase (RP) preparative HPLC analyses of the MeOH extract of the aerial parts of Artemisia armeniaca yielded four prenylated coumarins, 7-hydroxy-8-(4-hydroxy-3-methylbutoxy)coumarin (named armenin), 8-hydroxy-7-(4-hydroxy-3-methylbutoxy)coumarin (named isoarmenin), lacarol, and deoxylacarol, together with five other compounds, including three flavonoid glycosides, quercetin 3-O-β-D-glucopyranoside, rutin, and kaempferol 3-O-β-D-glucopyranoside, and chlorogenic acid, and tryptophan. (10E,12Z)-9-Hydroxyoctadeca-10,12-dienoic acid (β-dimorphecolic acid) was isolated from the CH(2)Cl(2) extract. Armenin and isoarmenin were new coumarins. Structures of all compounds were determined by spectroscopic means, including UV, MS, 1D- and 2D-NMR. The in vitro free-radical-scavenging property of the extracts and isolated compounds was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay.

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Phenolic Compounds from Artemisia iwayomogi and Their Effects on Osteoblastic MC3T3-E1 Cells

Cited by 19 publications

References 22 publications

Artemisia iwayomogiExtract Attenuates High-Fat Diet-Induced Obesity by Decreasing the Expression of Genes Associated with Adipogenesis in Mice

Artemisia iwayomogiExtract Attenuates High-Fat Diet-Induced Obesity by Decreasing the Expression of Genes Associated with Adipogenesis in Mice

Simultaneous quantification and validation of new peroxynitrite scavengers fromArtemisia iwayomogi

Armenin and Isoarmenin – Two Prenylated Coumarins from the Aerial Parts of Artemisia armeniaca

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