Phenolic compounds can delay the oxidation of polyunsaturated fatty acids and the growth of <i>Listeria monocytogenes</i>: structure‐activity relationships

Pernin, Aurélia; Dubois‐Brissonnet, Florence; Roux, Stéphanie; Masson, Marine; Bosc, Véronique; Maillard, Marie‐Noëlle

doi:10.1002/jsfa.9082

Cited by 26 publications

(31 citation statements)

References 46 publications

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“…It is interesting to investigate the structure-activity relationships for phenylethanoid glycosides 1-4, which have similar structures, and the main differences are the substituents at C-3 (R1), C-4 (R2) and C-4 0 (R3). It is inferred that the antioxidant activity of phenolics increases when there are free hydroxy groups in the molecule, which is consistent with the reported results [33]. Of the six flavonoids analysed (5-10), only luteolin (5) displayed strong antioxidant activities.…”

Section: Plos Onesupporting

confidence: 91%

Antioxidant activities of Clerodendrum cyrtophyllum Turcz leaf extracts and their major components

et al. 2020

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This study was designed to investigate the antioxidant properties of the extracts and subfractions of various polarities from Clerodendrum cyrtophyllum Turcz leaves and the related phenolic compound profiles. The ethyl acetate fraction (EAF) showed the most potent radical-scavenging activity for DPPH radicals, ABTS radicals, and superoxide anion (O 2 �-) radicals as well as the highest reducing power of the fractions tested; the n-butyl alcohol fraction (BAF) was the most effective in scavenging hydroxyl radical (OH �), and the dichloromethane fraction (DMF) exhibited the highest ferrous ion chelating activity. Twelve phenolic components were identified from the EAF of C. cyrtophyllum. Additionally, acteoside (1) was found to be a major component (0.803 g, 0.54%) and show DPPH and ABTS radical scavenging activities with IC 50 values of 79.65±3.4 and 23.00±1.5 μg/ml, indicating it is principally responsible for the significant total antioxidant effect of C. cyrtophyllum. Our work offers a theoretical basis for further utilization of C. cyrtophyllum as a potential source of natural, green antioxidants derived from plants.

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Section: Plos Onesupporting

confidence: 91%

Antioxidant activities of Clerodendrum cyrtophyllum Turcz leaf extracts and their major components

et al. 2020

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“…However, over 57% of color removal was achieved after a retention period of 35 h. The impeded decolorization process observed earlier at this initial concentration (2,600 ADMI) could be due to the predominant complex aromatic ring structure of the recalcitrant contaminants (such as colorants) which are not easily broken by the microbes' metabolic and enzymatic activities (Hameed and Ismail, 2018). In addition, the presence of other toxic compounds (such as sulphonic groups) exerts an inhibitory effect on the extracellular activities of the microbes (Luo et al, 2014;Pernin et al, 2018). Thus, these compounds antagonize the overall bio-decolorization processes (Pernin et al, 2018).…”

Section: Effect Of Initial Concentration At Varied Treatment Time Witmentioning

confidence: 88%

Decolorization of Palm Oil Mill Effluent by Klebsiella Pneumonia ABZ11: Remediation Efficacy and Statistical Optimization of Treatment Conditions

et al. 2020

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Colorants contained in palm oil mill effluent (POME) are recalcitrant and carcinogenic in nature. The commonly applied ponding treatment methods have been reported inefficient for remediating the concentration of the colorants before discharge. The need for sustainable and efficient treatment technique is crucial in order to preserve the environment. In this view, this study reported the first attempt to decolorize POME using a proliferate Klebsiella Pneumonia ABZ11 at varied inoculum sizes of 5-25% (v/v), initial color concentration (650-2,600 ADMI) and treatment time of 5-40 h. The treatment conditions were optimized using Response Surface Methodology. At optimal conditions of 20% (v/v) inoculum size, initial-color concentration of 2,600 ADMI, initial pH of 7 and 35 h treatment retention time, over 80.40% color removal was achieved with insignificant disparity compared with the model predicted value of 81.538%. Also, the Monod model excellently described the decolorization kinetic process with 0.9214 coefficient of correlation (R 2), and the calculated maximum growth µ max) and halfsaturation constant (K s) were 7.023 d −1 and 340.569 ADMI d −1 , respectively. This study revealed that the Klebsiella Pneumonia ABZ11 was highly prolific and such feature may favor a synergistic biodegradation process.

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“…This adds to the value of its antimicrobial activity. Quercetin affects the prokaryotic and eukaryotic cells by different modes of action and it is reported that antibacterial activity of quercetin is mediated by the inhibition of nucleic acid synthesis (Cushnie and Lamb 2005;Pernin et al 2018). The flavonoids including quercetin are known to exert their action by proton pump inhibition (PPI).…”

Section: Resultsmentioning

confidence: 99%

Anti‐biofilm and cytoprotective activities of quercetin againstPseudomonas aeruginosaisolates

Vipin

Mujeeburahiman

Ashwini

et al. 2019

Lett Appl Microbiol

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Increase in infection with multidrug resistant Pseudomonas aeruginosa is a serious global challenge in healthcare. Pseudomonas aeruginosa is capable of causing human infection in various sites and complicates the infection due to its virulence factors. This study was aimed to investigate the effect of quercetin, a dietary flavonoid against the virulence factors of P. aeruginosa and its cell protective effects on epithelial cells. Bactericidal activity, anti‐biofilm activity and effect on different virulence factors were carried out using standard methods by using five P. aeruginosa isolates. Cytotoxicity and cell protective effect of quercetin was evaluated by trypan blue dye exclusion assay. All the tested isolates were completely inhibited (100%) by quercetin at a concentration of 500 μg ml–1. It showed significant (P < 0·05) inhibitory effect on virulence factors including biofilm formation and showed significant protective effect on HEK 293T cells infected with P. aeruginosa strains. This study supports the role of quercetin against P. aeruginosa, by inhibiting virulence factors as well as its cytoprotective activity during bacterial infection either by attenuating the virulence or providing direct protective effect to the host cells. Significance and Impact of the Study The increase in infections caused by opportunistic pathogen Pseudomonas aeruginosa is a serious concern in the health care system. This study describes the beneficial effects of a dietary flavonoid, quercetin against pathogenic P. aeruginosa strains and its protective effect against the P. aeruginosa infection in HEK 293T cells in vitro.

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Phenolic compounds can delay the oxidation of polyunsaturated fatty acids and the growth of Listeria monocytogenes: structure‐activity relationships

Cited by 26 publications

References 46 publications

Antioxidant activities of Clerodendrum cyrtophyllum Turcz leaf extracts and their major components

Antioxidant activities of Clerodendrum cyrtophyllum Turcz leaf extracts and their major components

Decolorization of Palm Oil Mill Effluent by Klebsiella Pneumonia ABZ11: Remediation Efficacy and Statistical Optimization of Treatment Conditions

Anti‐biofilm and cytoprotective activities of quercetin againstPseudomonas aeruginosaisolates

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