Phenolic compounds based conjugates from dextran aldehyde and BSA: Preparation, characterization and evaluation of their anti-cancer efficacy for therapeutic applications

Rai, Sudheer; Kureel, Amit Kumar; Dutta, Parikshit; Mehrotra, Gopal K.

doi:10.1016/j.ijbiomac.2017.11.049

Cited by 32 publications

(15 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This method allowed precise morphological analysis of the three-dimensional structure and the morphology of the EPS surface, which contributes to the study of its functional, sensory, and physical properties [91]. The micrographs illustrated that the EPS surface was rough and irregular, with few pores (Figure 3), a result similar to a previous study [92]. The shape and surface characteristics may have been impacted by the extraction and purification methods used.…”

Section: Scanning Electron Microscopy (Sem)supporting

confidence: 70%

Biopolymer from Water Kefir as a Potential Clean-Label Ingredient for Health Applications: Evaluation of New Properties

et al. 2022

View full text Add to dashboard Cite

The present work aimed to characterize the exopolysaccharide obtained from water kefir grains (EPSwk), a symbiotic association of probiotic microorganisms. New findings of the technological, mechanical, and biological properties of the sample were studied. The EPSwk polymer presented an Mw of 6.35 × 105 Da. The biopolymer also showed microcrystalline structure and characteristic thermal stability with maximum thermal degradation at 250 °C. The analysis of the monosaccharides of the EPSwk by gas chromatography demonstrated that the material is composed of glucose units (98 mol%). Additionally, EPSwk exhibited excellent emulsifying properties, film-forming ability, a low photodegradation rate (3.8%), and good mucoadhesive properties (adhesion Fmax of 1.065 N). EPSwk presented cytocompatibility and antibacterial activity against Escherichia coli and Staphylococcus aureus. The results of this study expand the potential application of the exopolysaccharide from water kefir as a potential clean-label raw material for pharmaceutical, biomedical, and cosmetic applications.

show abstract

Section: Scanning Electron Microscopy (Sem)supporting

confidence: 70%

Biopolymer from Water Kefir as a Potential Clean-Label Ingredient for Health Applications: Evaluation of New Properties

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Phenolic compounds are simple and naturally occurring organic compounds bearing an aromatic ring with one or more hydroxyl groups (with or without side chain), they received considerable attention due to their biological functions such as anti-carcinogen, anti-ageing, anti-diabetic, anti-mutagen and immunostimulatory roles [ 40 , 41 ]. Among the most extensively administered phenolic drugs, salbutamol, terbutaline, thymol, favipiravir, remdesivir, dexamethasone and hydrochloroquine are highly recognized β 2 -adrenergic receptor agonists, antiseptic, antimicrobial agent and antiviral agents, respectively ( Figure 3 ) [ 42 , 43 ].…”

Section: Pharmacological Properties Of Phenol Derivativesmentioning

confidence: 99%

Pyridine Scaffolds, Phenols and Derivatives of Azo Moiety: Current Therapeutic Perspectives

et al. 2021

View full text Add to dashboard Cite

Synthetic heterocyclic compounds have incredible potential against different diseases; pyridines, phenolic compounds and the derivatives of azo moiety have shown excellent antimicrobial, antiviral, antidiabetic, anti-melanogenic, anti-ulcer, anticancer, anti-mycobacterial, anti-inflammatory, DNA binding and chemosensing activities. In the present review, the above-mentioned activities of the nitrogen-containing heterocyclic compounds (pyridines), hydroxyl (phenols) and azo derivatives are discussed with reference to the minimum inhibitory concentration and structure–activity relationship, which clearly indicate that the presence of nitrogen in the phenyl ring; in addition, the hydroxyl substituent and the incorporation of a diazo group is crucial for the improved efficacies of the compounds in probing different diseases. The comparison was made with the reported drugs and new synthetic derivatives that showed recent therapeutic perspectives made in the last five years.

show abstract

“…[27][28][29][30] The strategy to increase the knowledge about the positive contribution of plant-based foods in the diets, especially with regard to (poly)phenols, is focusing the efforts of research in the field of food science and technology. 31,32 The biological properties of (poly)phenols have been demonstrated in studies that have noticed them as potential molecules to combat different types of cancer, [33][34][35] and their healthy attributions to cardiovascular 6 and neurological health. 36,37 However, it should be considered that the health-promoting effect of these compounds can be overshadowed by a reduced bioavailability due to low intestinal absorption, rapid biotransformation, and the activity of gut microbiota.…”

Section: Introductionmentioning

confidence: 99%

“…The biological properties of (poly)phenols have been demonstrated in studies that have noticed them as potential molecules to combat different types of cancer, 33‐35 and their healthy attributions to cardiovascular 6 and neurological health 36,37 . However, it should be considered that the health‐promoting effect of these compounds can be overshadowed by a reduced bioavailability due to low intestinal absorption, rapid biotransformation, and the activity of gut microbiota 38‐40 …”

Section: Introductionmentioning

confidence: 99%

Contribution of the diverse experimental models to unravelling the biological scope of dietary (poly)phenols

et al. 2022

View full text Add to dashboard Cite

The health benefits associated with (poly)phenols need to be supported by robust and insightful information on their biological effects. The use of in vitro, ex vivo, and in vivo models is crucial to demonstrate functionalities in specific targets. In this regard, bioaccessibility, bioavailability, and tissue/organ distribution need to be fully understood and established. In addition, the structure–function relationships, concerning both descriptive and mechanistic information, between specific compounds and therapeutic objectives, need to be supported by results obtained from in vivo studies. Nevertheless, these studies are not always possible or have some limitations, particularly concerning the mechanistic information explaining the health benefits provided that should be covered with complementary experimental models. Based on these premises, this review aims to overview the contribution of the separate experimental approaches to gain insights into the bioaccessibility, bioavailability, and bioactivity of (poly)phenols. To achieve this objective, recent evidence available on the linkage of healthy/functional foods with the incidence of non‐communicable pathologies is presented. The different experimental approaches provide complementary information that allows advances to be applied to the knowledge gained on the functional properties and mechanistic facts responsible for the health attributions of polyphenols. © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

show abstract

Phenolic compounds based conjugates from dextran aldehyde and BSA: Preparation, characterization and evaluation of their anti-cancer efficacy for therapeutic applications

Cited by 32 publications

References 37 publications

Biopolymer from Water Kefir as a Potential Clean-Label Ingredient for Health Applications: Evaluation of New Properties

Biopolymer from Water Kefir as a Potential Clean-Label Ingredient for Health Applications: Evaluation of New Properties

Pyridine Scaffolds, Phenols and Derivatives of Azo Moiety: Current Therapeutic Perspectives

Contribution of the diverse experimental models to unravelling the biological scope of dietary (poly)phenols

Contact Info

Product

Resources

About