Phenolic Compounds and Antifungal Activity of &lt;i&gt;Hedera helix&lt;/i&gt; L. (Ivy)  Flowers and Fruits

Pârvu, Marcel; Vlase, Laurian; Pârvu, Alina Elena; Roşca-Casian, Oana; Gheldiu, Ana-Maria; Parvu, Ovidiu

doi:10.15835/nbha4319644

Cited by 19 publications

(15 citation statements)

References 7 publications

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“…Common ivy or English ivy ( Hedera helix L ., Araliaceae) has been used as a medicinal plant due to its antimicrobial and antifungal properties [ 34 , 35 ]. The active constituents in ivy fruit include triterpene saponins that are mainly derived from hederagenin, as well as fatty acids and polyacetylenes [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Improving the antiprotozoal effect of saponins in the rumen by combination with glycosidase inhibiting iminosugars or by modification of their chemical structure

et al. 2017

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The antiprotozoal effect of saponins is transitory, as when saponins are deglycosylated to sapogenins by rumen microorganisms they become inactive. We hypothesised that the combination of saponins with glycosidase-inhibiting iminosugars might potentially increase the effectiveness of saponins over time by preventing their deglycosylation in the rumen. Alternatively, modifying the structure of the saponins by substituting the sugar moiety with other small polar residues might maintain their activity as the sugar substitute would not be enzymatically cleaved. The aim of this in vitro study was to evaluate the acute antiprotozoal effect and the stability of this effect over a 24 h incubation period using ivy saponins, a stevia extract rich in iminosugars, ivy saponins with stevia extract, and a chemically modified ivy saponin, hederagenin bis-succinate (HBS). The effects on fermentation parameters and rumen bacterial communities were also studied. Ivy saponins with stevia and HBS had a greater antiprotozoal effect than ivy saponins, and this effect was maintained after 24 h of incubation (P<0.001). The combination of ivy and stevia extracts was more effective in shifting the fermentation pattern towards higher propionate (+39%) and lower butyrate (-32%) and lower ammonia concentration (-64%) than the extracts incubated separately. HBS caused a decrease in butyrate (-45%) and an increase in propionate (+43%) molar proportions. However, the decrease in ammonia concentration (-42%) observed in the presence of HBS was less than that caused by ivy saponins, either alone or with stevia. Whereas HBS and stevia impacted on bacterial population in terms of community structure, only HBS had an effect in terms of biodiversity (P<0.05). It was concluded that ivy saponins with stevia and the modified saponin HBS had a strong antiprotozoal effect, although they differed in their effects on fermentation parameters and bacteria communities. Ivy saponins combined with an iminosugar-rich stevia extract and/or HBS should be evaluated to determine their antiprotozoal effect in vivo.

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Section: Discussionmentioning

confidence: 99%

Improving the antiprotozoal effect of saponins in the rumen by combination with glycosidase inhibiting iminosugars or by modification of their chemical structure

et al. 2017

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“…EtOH); results are the mean ± SD of 4 replicates. extract (MIC = 10-14%) [23]. These findings suggest that ivy flowers contain principles with higher antifungal activities and might be more efficient in treating plant mycoses.…”

Section: Resultsmentioning

confidence: 75%

Chemical composition and antifungal activity of Hedera helix leaf ethanolic extract

Roşca-Casian

Mircea

Vlase

et al. 2017

Acta Biologica Hungarica

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The 50% ethanol extract obtained from Hedera helix leaves was investigated regarding the presence and quantity of polyphenols, sterols and in vitro antifungal activity against phytopathogenic fungi. The chemical analysis revealed the presence of rutin, quercetin and kaempferol in the non-hydrolysed sample and quercetin and kaempferol in the hydrolysed sample and stigmasterol in the ivy leaf extract (nonhydrolysed sample). The antifungal activity against phytopathogenic fungi (Aspergillus niger, Botrytis cinerea, B. tulipae, Fusarium oxysporum f. sp. tulipae, Penicillium gladioli, and Sclerotinia sclerotiorum) was assessed using an agar dilution assay. The results are expressed as the minimum inhibitory concentration (MIC = 10-14%) and were compared to a synthetic antifungal drug - fluconazole (MIC = 8-30%). This report presents the first screening of the antifungal activity of the ivy leaf extract on these plant pathogenic fungi species, aiming to use the ivy leaf extract for controlling different diseases of vegetables and ornamental plants, in addition to human disorders.

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“…Flavonoids and Phenolic compounds were reported to have antibacterial activity (Cushnie and Lamb, 2005;Aziz et al, 1998;Rauha et al, 2000). Antifungal activity was found due to the presence of flavonoid and phenolic compounds (Harborne and Williams, 2000;Zheng et al, 1996;Parvu et al, 2015). Both flavonoid and phenolic compounds were proven to be present in Senecio glaucus subsp.…”

Section: -Antimicrobial Activitymentioning

confidence: 99%

PHYTOCHEMICAL AND BIOLOGICAL STUDY OF (Senecio glaucus subsp. coronopifolius ) (MAIRE) C. ALEXANDER GROWING IN EGYPT

Mohamed

2015

Al-Azhar Journal of Pharmaceutical Sciences

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Senecio glaucus subsp. coronopifolius (Maire) C. Alexander is wild annual herb distributed in the Egyptian deserts. Total phenolic and flavonoid content of plant root were determined using both HPLC and colorimetric analysis. Syringic acid and hesperidin (1378.802 and 6638.247 mg / 100 gm. dried plant root powder, respectively) were of the highest concentration compounds resulted from HPLC analysis of total phenolic and flavonoid content. The colorimetric estimation of total phenolic and flavonoid content resulted in concentration of (98.23 ± 0.28 mg/gm. expressed as Gallic acid equivalent (GAE) and 35.9± 0.17 mg/gm. expressed as quercetin equivalent (QE), respectively). GC-MS analysis of un-saponifiable matters and fatty acid methyl esters of the plant leaves indicated that octacosane (11.85%) and linolenic acid methyl ester (31.07%) (poly-unsaturated fatty acid) were the major identified compounds, respectively. The DNA of the plant was analyzed using twelve random decamer primers. A total of 52 random amplified polymorphic DNA (RAPD) markers were identified. Root extracts (ethyl acetate, acetone and methyl alcohol) were subjected to determine the antimicrobial behavior and also their cytotoxic activity, by using (3-(4, 5dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) (MTT) assay against colon carcinoma cell lines (HCT-116). Among the fore mentioned extracts, root ethyl acetate extract gave appreciable antibacterial and antifungal behavior and also had promising cytotoxic activity with IC 50 = 7.39 ±1.2 µg/ml. Root methyl alcohol extract showed antioxidant activity with IC 50 = 79.57 ± 0.74 µg/ml, using 2, 2-diphenyl-1picrylhydrazyl (DPPH) assay.

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Phenolic Compounds and Antifungal Activity of <i>Hedera helix</i> L. (Ivy) Flowers and Fruits

Cited by 19 publications

References 7 publications

Improving the antiprotozoal effect of saponins in the rumen by combination with glycosidase inhibiting iminosugars or by modification of their chemical structure

Improving the antiprotozoal effect of saponins in the rumen by combination with glycosidase inhibiting iminosugars or by modification of their chemical structure

Chemical composition and antifungal activity of Hedera helix leaf ethanolic extract

PHYTOCHEMICAL AND BIOLOGICAL STUDY OF (Senecio glaucus subsp. coronopifolius ) (MAIRE) C. ALEXANDER GROWING IN EGYPT

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