Phenolic composition, antioxidant, anti-wrinkles and tyrosinase inhibitory activities of cocoa pod extract

Karim, Azila Abdul; Azlan, Azrina; Ismail, Amin; Hashim, Puziah; Gani, Siti Salwa Abd; Zainudin, Badrul Hisyam; Abdullah, Nur Azilah

doi:10.1186/1472-6882-14-381

Cited by 130 publications

(59 citation statements)

References 59 publications

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“…The chromatogram(Figure 3)shows that vanillic acid (retention time: 9.17 min; peak area: 31.10%) was the phenolic antioxidant detected. The presence of quercetine and caffeic acid in the cocoa pods extract has been previously reported byKarim, Azlan, Ismail, Hashim, Abd Gani, et al (2014) andFapohunda and Afolayan (2012),…”

supporting

confidence: 77%

Polyphenol antioxidants from cocoa pods: Extraction optimization, effect of the optimized extract, and storage time on the stability of palm olein during thermoxidation

Teboukeu

Djikeng

Klang

et al. 2018

J Food Process Preserv

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This study was conducted in order to optimize the extraction process of phenolic antioxidants in cocoa pods and to evaluate the effect of optimized extract and storage time on the oxidative stability of palm olein heated at 180 °C using response surface methodology (RSM). The optimization of the extraction process of cocoa pods antioxidants was done and the results showed that the total polyphenols of 153.51 mg GAE/g and scavenging activity of 100% were obtained under optimal conditions. Vanillic acid was the phenolic antioxidant detected in the optimized extract using HPLC‐DAD (diode array detector). Rancimat test showed this extract was efficient in delaying palm olein oxidation. To preserve quality of palm olein during heating at 180 °C, RSM concerning iodine value and thiobarbituric acid value proposes to supplement the oil with 2,000 ppm of cocoa pods extract during 1–7 days (03 hr heating cycle per day) of treatments. Practical applications To improve the oxidative stability and shelf‐life of vegetable oils, only few natural sources who are supposed to be safer than synthetic antioxidants have been authorized for industrial purpose (case of rosemary). Therefore, there is a strong rational to continue the search of new natural sources of antioxidants by screening plant materials. This study can be useful for the development of industrial extraction process of cocoa pods and its application as an ingredient to delay lipid oxidation in oils.

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supporting

confidence: 77%

Polyphenol antioxidants from cocoa pods: Extraction optimization, effect of the optimized extract, and storage time on the stability of palm olein during thermoxidation

Teboukeu

Djikeng

Klang

et al. 2018

J Food Process Preserv

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“…Budiyanto et al [51] reported that olive oil topically applied after UVB exposure can effectively reduce UVB-induced murine skin tumors, possibly via its antioxidant effects in reducing DNA damage by reactive oxygen species, and that the effective component may be labile to UVB. This antioxidant activity presents high potential as a UVB sunscreen agent [10,52]. Argan oil can improve skin elasticity [53] and skin hydration by restoring the barrier function and maintaining the water-holding capacity [54].…”

Section: Discussionmentioning

confidence: 99%

“…Dakhil et al [57] have reported that safflower oil characteristics can make it a main ingredient in the preparation of topical agents for the treatment of various skin problems. Abdul Karim et al [52] recommended the possible use of cocoa pod extract as an ingredient in functional cosmetic products, specifically for anti-wrinkles as well as skin whitening or sunscreen products in combination with natural plant extracts to widen the spectrum of protection from sun rays.…”

Section: Discussionmentioning

confidence: 99%

Phenol Content and Antioxidant and Antiaging Activity of Safflower Seed Oil (Carthamus Tinctorius L.)

et al. 2019

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The phenol content of vegetable oil and its antioxidant activity are of primary interest for human health. Oilseed species are considered important sources of these compounds with medicinal effects on a large scale. Total phenol content (TPC) and antioxidant activity (AA) of safflower oil were previously studied. Nevertheless, there is no report on genotypic differences and antiaging activity of safflower oil. The aim of this study was to determine the TPC, diphenyl-picrylhydrazyl (DPPH), and antiaging activity on three respective accessions from Syria, France, and Algeria of seed oil of safflower grown under semi-arid conditions during 3 consecutive years (2015, 2016, and 2017). The results showed that phenol content as well as antioxidant and antiaging activity varied according to both genotype and years. In 2017, the mean value of TPC in oil seed was two times higher than in 2015 and 2016. Moreover, accessions presented different TPC values depending on the year. The highest antioxidant activity was observed among accessions in 2017 compared to 2015 and 2016. As expected, a positive correlation was found between TPC and antioxidant activity. The inhibition in the collagenase assay was between 47% and 72.1% compared to the positive control (83.1%), while inhibition in the elastase assay of TPC ranged from 32.2% to 70.3%, with the positive control being 75.8%. These results highlight the interest of safflower oil as a source of phenols with valuable antioxidant and antiaging activity, and uses for cosmetics.

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“…Therefore, the present study indicates that T. cacao extracts and gel both have a potent anti-microbial activity against various skin pathogens [93] [94] [95]. However, MIC values (Table 10) indicates that it has higher action against fungal strains than that of the bacterial strains [96].…”

Section: Discussionmentioning

confidence: 78%

Controllable Transdermal Drug Delivery of Theobroma cacao Extract Based Polymeric Hydrogel against Dermal Microbial and Oxidative Damage

Agarwal¹,

Tyagi²,

Agarwal³

et al. 2019

FNS

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Human dermal layers are directly bared to the external environmental adversities like pollution, radiation, dust along with various chemical and mechanical stress conditions which constantly lead to the oxidative stress, eventually forming free radicals. These conditions also support the dermal microbial infections by invading the cutaneous layers. Therefore, the most efficient approach accepted globally to combat these complications is to opt for transdermal application of exogenous antioxidants which helps in reducing the ill effects of oxidative stress and promotes the DNA repair. However, many scientific findings exhibited the potential role of Theobroma cacao for providing efficient skin protection. Theobroma cacao known for its vital procyanidin flavonoids, phenolic compounds, methylxanthines, catechin and epicatechin phytoconstituents with numerous health benefits, besides helping in smoothening and softening the damaged skin. These therapeutic benefits of cocoa phytocompounds are attributed to its anti-inflammatory and antioxidative characteristics. This study addresses the fabrication and optimizations of Theobroma cacao extract loaded carbopol hydrogel system for increased antioxidative and antimicrobial effects. It was found in the studies that the hydrogel-based T. cacao extract (TCHG) has significantly improved the therapeutic index of the extract, making it more suitable for transdermal application. The optimized hydrogel was further characterized by physicochemical parameters, SEM analysis and in-vitro release kinetics. The reported findings showed the sustained compound release with comparatively significant antimicrobial activity of TCHG against microbial

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Phenolic composition, antioxidant, anti-wrinkles and tyrosinase inhibitory activities of cocoa pod extract

Cited by 130 publications

References 59 publications

Polyphenol antioxidants from cocoa pods: Extraction optimization, effect of the optimized extract, and storage time on the stability of palm olein during thermoxidation

Polyphenol antioxidants from cocoa pods: Extraction optimization, effect of the optimized extract, and storage time on the stability of palm olein during thermoxidation

Phenol Content and Antioxidant and Antiaging Activity of Safflower Seed Oil (Carthamus Tinctorius L.)

Controllable Transdermal Drug Delivery of Theobroma cacao Extract Based Polymeric Hydrogel against Dermal Microbial and Oxidative Damage

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