Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

Tauchen, Jan; Bortl, Ludvik; Huml, Lukáš; Mikšátková, Petra; Doskočil, Ivo; Maršík, Petr; Villegas, Pablo Pedro Panduro; Flores, Ymber Bendezu; Damme, Patrick Van; Lojka, Bohdan; Havlík, Jaroslav; Lapčı́k, Oldřich; Kokoška, Ladislav

doi:10.1016/j.bjp.2016.03.016

Cited by 56 publications

(32 citation statements)

References 39 publications

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“…Table 3 shows the phenolic compounds present in the buriti pulp. Some phenolic compounds of this fruit [20] such as syringic acid, protocatechuic acid, catechin and ferulic acid present antimicrobial activity as reported by various authors [21 -24]. In this way, the variables studied correlate with the phenolic content and with the antimicrobial activity.…”

Section: Discussionsupporting

confidence: 60%

Evaluation of the Antimicrobial Activity of Buriti (Mauritia Flexuosa) Pulp Extracts

Monteiro¹,

Santos²,

Silva³

et al. 2019

TOFSJ

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Background:Buriti (Mauritia flexuosa) is a palm tree typical of the Amazon region. This plant belongs to the Arecaceae family and is economically important because it contains substances important for the food, cosmetic and pharmaceutical industries. It has, in its fruits, compounds with antimicrobial potential. Objective:The objective of this study was to evaluate the minimal inhibitory concentration and minimum bactericidal concentration of the Buriti extracts against the four bacteria: Salmonella enterica serotype Typhimurium ATCC 14028, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853. Methods:15 extracts from buriti pulp were obtained varying in temperature, mass of buriti and ethanol content. The antimicrobial activity of these extracts was evaluated. To determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), the methodology recommended by the Clinical and Laboratory Standards Institute was followed. Results:The results showed which buriti pulp extracts had strong inhibitory activity. Gram-positive results ranged from 21 to 78 μg.mL -1 . For Gramnegative, they ranged from 30 to 111 μg.mL -1. Conclusion:The buriti extracts significantly slowed the growth of the tested bacteria.

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Section: Discussionsupporting

confidence: 60%

Evaluation of the Antimicrobial Activity of Buriti (Mauritia Flexuosa) Pulp Extracts

Monteiro¹,

Santos²,

Silva³

et al. 2019

TOFSJ

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“…Excessive iron accumulation can induce significant toxicity both by generation of reactive oxygen species and because of the lack iron excretion regulation in humans ( Nurchi et al, 2016 ). Previous studies have shown the correlation between phenolic compounds and antioxidant activity, in addition to associating the chelating activity of natural products with their composition in the samples ( Loizzo et al, 2012 ; Koolen et al, 2013 ; Cândido, Silva & Agostini-Costa, 2015 ; Tauchen et al, 2016 ). In fact, the structure of phenolic compounds, such as phenolic acids and flavonoids, is decisive for radical elimination and metal chelating activities.…”

Section: Discussionmentioning

confidence: 99%

Chemical analysis and evaluation of antioxidant and antimicrobial activities of fruit fractions ofMauritia flexuosaL. f. (Arecaceae)

Nonato

Leite

Pereira

et al. 2018

PeerJ

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BackgroundFruit consumption is currently considered beyond the nutritional aspects because of the important roles in disease prevention and benefits to health. The objective of this study was to characterize the chemical profile and evaluate the antioxidant and antimicrobial properties of different fractions obtained from fruit pulps of Mauritia flexuosa (MFFs).MethodsInitially, chloroform, ethyl acetate and ethanol fractions were obtained from the pulps. Quantifications of total phenols and flavonoids were performed using the methods of Folin-Ciocalteu and complexation with aluminum chloride, respectively. Standard samples were used to identify and quantify phenolic acids and flavonoids using high-performance liquid chromatography with a diode-array detector (HPLC-DAD). The antioxidant capacity of the fractions was verified by sequestration of the free radical 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid (ABTS) and iron chelating activity. The antimicrobial activity was determined using the microdilution method and the modulating activity was determined using sub-inhibitory concentrations of the fractions in association with antibiotics.ResultsThe chemical analyzes revealed the presence of catechin, caffeic acid, rutin, orientin, quercetin, apigenin, luteolin and kaempferol, where all are present in the ethyl acetate fraction. The fractions exhibited moderate antioxidant and antimicrobial activities against Gram-positive and Candida strains in addition to modulating the activity of conventional antibiotics. The most expressive result was obtained from the association of the chloroform fraction with cefotaxime, which produced a synergistic effect, reducing the minimum inhibitory concentration (MIC) of the antibiotic from 1,024 to 256 μg/mL.DiscussionThe fractions presented a constitution rich in phenolic compounds, especially flavonoids. The data obtained demonstrated that the fractions presented moderate antioxidant activity by acting both as primary and secondary antioxidants. The fractions presented antimicrobial and antibiotic potentiating activities, being the first record of modulating effect of fractions of this species against the studied microbial strains, but failed in modulating the activity of antifungal drugs, indicating that this plant has the potential to be used in the development of therapeutic alternatives against resistant bacteria. The constitution phenolic the fractions may be responsible for their pharmacological properties in vitro.

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“…Chlorogenic acid (MM = 354, C 16 H 18 O 9 , Table 1 ), showed signals at 355 [M + H] + , 353 [M − H] − , 162 [caffeic acid], 190 [quinic acid]. It had already been isolated in fruit of Gardenia jasminoides Ellis (Rubiaceae) [ 31 , 34 ], but the first time is described in the Genipa genus.…”

Section: Resultsmentioning

confidence: 99%

Isolation and Identification of the Five Novel Flavonoids from Genipa americana Leaves

et al. 2018

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Genipa americana is a medicinal plant popularly known as “jenipapo”, which occurs in Brazil and belongs to the Rubiaceae family. It is a species widely distributed in the tropical Central and South America, especially in the Cerrado biome. Their leaves and fruits are used as food and popularly in folk medicine to treat anemias, as an antidiarrheal, and anti-syphilitic. Iridoids are the main secondary metabolites described from G. americana, but few studies have been conducted with their leaves. In this study, the aim was to chemical approach for identify the main compounds present at the extract of G. americana leaves. The powdered leaves were extracted by maceration with EtOH: water (70:30, v/v), following liquid-liquid partition with petroleum ether, chloroform, ethyl acetate and n-butanol. A total of 13 compounds were identified. In addition three flavonoids were isolated from the ethyl acetate fraction: quercetin-3-O-robinoside (GAF 1), kaempferol-3-O-robinoside (GAF 2) and isorhamnetin-3-O-robinoside (GAF 3) and, from n-butanol fraction more two flavonoids were isolated, kaempferol-3-O-robinoside-7-O-rhamnoside (robinin) (GAF 4) and isorhamnetin-3-O-robinoside-7-rhamnoside (GAF 5). Chemical structures of these five flavonoids were elucidated using spectroscopic methods (MS, 1H and 13C-NMR 1D and 2D). These flavonoids glycosides were described for the first time in G. americana.

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Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

Cited by 56 publications

References 39 publications

Evaluation of the Antimicrobial Activity of Buriti (Mauritia Flexuosa) Pulp Extracts

Evaluation of the Antimicrobial Activity of Buriti (Mauritia Flexuosa) Pulp Extracts

Chemical analysis and evaluation of antioxidant and antimicrobial activities of fruit fractions ofMauritia flexuosaL. f. (Arecaceae)

Isolation and Identification of the Five Novel Flavonoids from Genipa americana Leaves

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