Phenolic components and antioxidant activity of Fernblock, an
aqueous extract of the aerial parts of the fern Polypodium
leucotomos

Garcia, Francielle P.; Pivel, J.P.; Guerrero, Antonio; Brieva, Aurora; Martínez-Alcázar, Ma Paz; Caamano-Somoza, M; González, Sandra Cecilia Esparza

doi:10.1358/mf.2006.28.3.985227

Cited by 67 publications

(40 citation statements)

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“…The methods for obtaining the extract have been previously published [34]. The extract was stored at room temperature and shielded from light following the provider’s instructions, and then a stock solution was prepared at a concentration of 10 mg/mL in distilled water, under agitation at 25–30 °C.…”

Section: Methodsmentioning

confidence: 99%

Fernblock Prevents Dermal Cell Damage Induced by Visible and Infrared A Radiation

Zamarrón

Lorrio

González

et al. 2018

IJMS

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Sun overexposure leads to higher risk of photoaging and skin cancer. The contribution of infrared (IR) and visible light (VIS) radiation is currently being taken into account in their pathogenesis. Erythema, hyperpigmentation, genotoxicity or the increase of matrix metalloproteinases (MMPs) expression are some of the effects induced by these types of radiation. Extracts of various botanicals endowed with antioxidant activity are emerging as new photoprotective compounds. A natural extract from Polypodium leucotomos (Fernblock®, FB) has antioxidant and photoprotective properties and exhibits a strong anti-aging effect. In this study, we evaluated the protective capacity of FB against the detrimental effects of infrared A (IRA) and VIS radiation in human dermal fibroblasts. We analyzed the effects of FB on the morphology, viability, cell cycle and expression of extracellular matrix components of fibroblasts subjected to VIS and IRA. Our results indicate that FB prevents cell damage caused by VIS and IRA. Moreover, it reduces the increase in MMP-1 and cathepsin K expression induced by both VIS and IRA radiation, and curbs alterations in fibrillin 1, fibrillin 2 and elastin expression. All these findings support FB as a feasible approach to prevent or treat skin damage caused by IRA or VIS exposure.

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Section: Methodsmentioning

confidence: 99%

Fernblock Prevents Dermal Cell Damage Induced by Visible and Infrared A Radiation

Zamarrón

Lorrio

González

et al. 2018

IJMS

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show abstract

“…A major part of its photoprotective properties rely on its antioxidant properties due to its high phenolics content. Fernblock’s phenolics moiety include mostly benzoates and cinnamates, e.g., caffeic and ferulic acids [20]. Caffeic acid inhibits UV-induced peroxide and nitric oxide (NO) formation, whereas ferulic acid quenches UV photons [21,22].…”

Section: Fernblock: a Multi-pronged Approach To Photoprotectionmentioning

confidence: 99%

Fernblock, a Nutriceutical with Photoprotective Properties and Potential Preventive Agent for Skin Photoaging and Photoinduced Skin Cancers

González

Gilaberte

Philips

et al. 2011

IJMS

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Many phytochemicals are endowed with photoprotective properties, i.e., the capability to prevent the harmful effects of excessive exposure to ultraviolet (UV) light. These effects include photoaging and skin cancer, and immunosuppression. Photoprotection is endowed through two major modes of action: UV absorption or reflection/scattering; and tissue repair post-exposure. We and others have uncovered the photoprotective properties of an extract of the fern Polypodium leucotomos (commercial name Fernblock). Fernblock is an all-natural antioxidant extract, administered both topically (on the skin) or orally. It inhibits generation of reactive oxygen species (ROS) production induced by UV including superoxide anion. It also prevents damage to the DNA, inhibits UV-induced AP1 and NF-κB, and protects endogenous skin natural antioxidant systems, i.e., CAT, GSH, and GSSR. Its photoprotective effects at a cellular level include a marked decrease of UV-mediated cellular apoptosis and necrosis and a profound inhibition of extracellular matrix remodeling. These molecular and cellular effects translate into long-term inhibition of photoaging and carcinogenesis that, together with its lack of toxicity, postulate its use as a novel-generation photoprotective nutriceutical of phytochemical origin.

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“…It is commonly used as a traditional medicine in South America to make poultices and treat psoriasis and other skin disorders, although with variable success . The hydrophilic extract of the leaves of P. leucotomos consists of coumaric acid, ferulic acid, caffeic acid, vanillic acid, 3‐caffeoylquinic acid, and chlorogenic acid . This extract provided antioxidant activities, inhibiting of ROS generation, scavenging the superoxide anion, and SOD .…”

Section: Natural Products As Photoprotectionmentioning

confidence: 99%

Natural products as photoprotection

Saewan

Jimtaisong

2015

J of Cosmetic Dermatology

214

161

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The rise in solar ultraviolet radiation on the earth's surface has led to a depletion of stratospheric ozone over recent decades, thus accelerating the need to protect human skin against the harmful effects of UV radiation such as erythema, edema, hyperpigmentation, photoaging, and skin cancer. There are many different ways to protect skin against UV radiation's harmful effects. The most popular way to reduce the amount of UV radiation penetrating the skin is topical application of sunscreen products that contain UV absorbing or reflecting active molecules. Based on their protection mechanism, the active molecules in sunscreens are broadly divided into inorganic and organic agents. Inorganic sunscreens reflect and scatter UV and visible radiation, while organic sunscreens absorb UV radiation and then re-emit energy as heat or light. These synthetic molecules have limited concentration according to regulation concern. Several natural compounds with UV absorption property have been used to substitute for or to reduce the quantity of synthetic sunscreen agents. In addition to UV absorption property, most natural compounds were found to act as antioxidants, anti-inflammatory, and immunomodulatory agents, which provide further protection against the damaging effects of UV radiation exposure. Compounds derived from natural sources have gained considerable attention for use in sunscreen products and have bolstered the market trend toward natural cosmetics. This adds to the importance of there being a wide selection of active molecules in sunscreen formulations. This paper summarizes a number of natural products derived from propolis, plants, algae, and lichens that have shown potential photoprotection properties against UV radiation exposure-induced skin damage.

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Phenolic components and antioxidant activity of Fernblock, an aqueous extract of the aerial parts of the fern Polypodium leucotomos

Cited by 67 publications

References 0 publications

Fernblock Prevents Dermal Cell Damage Induced by Visible and Infrared A Radiation

Fernblock Prevents Dermal Cell Damage Induced by Visible and Infrared A Radiation

Fernblock, a Nutriceutical with Photoprotective Properties and Potential Preventive Agent for Skin Photoaging and Photoinduced Skin Cancers

Natural products as photoprotection

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