Phenolic alkaloid oleracein E attenuates oxidative stress and neurotoxicity in AlCl3-treated mice

Li, Lingyu; Yang, Jiao; Jin, Tianyun; Sun, Hongxiang; Li, Shaoqiang; Jin, Cuirong; Hu, Shuiyao; Ji, Jianbo; Xiang, Lan

doi:10.1016/j.lfs.2017.10.019

Cited by 17 publications

(15 citation statements)

References 28 publications

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“…[44]. These inconsistencies may be due to differences among animals, dosages, times, experimental conditions, or experimental procedures [45,46]. Thus, in our study, treatment with Al 3+ (7.5 mg/kg/day [0.15 LD 50 ], 21 days, i.p.)…”

Section: Discussionmentioning

confidence: 84%

“…SOD activity remained unchanged after all treatments in our study (Figure 5a,b). The data on Al 3+ influence on the activities of antioxidant enzymes is not consistent, and might depend on the dosage, treatment duration, and experimental conditions [45,46]. Al 3+ was shown to decrease brain CAT activity in Swiss albino mice (50 mg/kg/day, 60 days, p.o.)…”

Section: Discussionmentioning

confidence: 97%

“…[64]. Moreover, one report showed that brain CAT activity significantly decreased, whereas brain SOD activity was not altered in Al 3+ treated Kunming mice (40 mg/kg/day, i.p., 28 days) [46]. The impact of rosmarinic acid and carvacrol on antioxidant enzyme activity also depends on their dosage.…”

Section: Discussionmentioning

confidence: 99%

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Natural Compounds Rosmarinic Acid and Carvacrol Counteract Aluminium-Induced Oxidative Stress

et al. 2020

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Aluminum accumulation, glutathione (GSH) and malondialdehyde (MDA) concentrations as well as catalase (CAT) and superoxide dismutase (SOD) activities were determined in erythrocytes and brain and liver homogenates of BALB/c mice treated with Al 3+ (7.5 mg/kg/day (0.15 LD 50 ) as AlCl 3 (37.08 mg/kg/day), whereas HCl (30.41 mg/kg/day) was used as Cl − control, the treatments were performed for 21 days, i.p., in the presence and absence of rosmarinic acid (0.2805 mg/kg/day (0.05 LD 50 ), 21 days, i.g.) or carvacrol (0.0405 mg/kg/day (0.05 LD 50 ), 21 days, i.g.). The treatment with AlCl 3 increased GSH concentration in erythrocytes only slightly and had no effect on brain and liver homogenates. Rosmarinic acid and carvacrol strongly increased GSH concentration in erythrocytes but decreased it in brain and liver homogenates. However, AlCl 3 treatment led to Al accumulation in mice blood, brain, and liver and induced oxidative stress, assessed based on MDA concentration in the brain and liver. Both rosmarinic acid and carvacrol were able to counteract the negative Al effect by decreasing its accumulation and protecting tissues from lipid peroxidation. AlCl 3 treatment increased CAT activity in mice brain and liver homogenates, whereas the administration of either rosmarinic acid or carvacrol alone or in combination with AlCl 3 had no significant effect on CAT activity. SOD activity remained unchanged after all the treatments in our study. We propose that natural herbal phenolic compounds rosmarinic acid and carvacrol could be used to protect brain and liver against aluminum induced oxidative stress leading to lipid peroxidation.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 97%

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Natural Compounds Rosmarinic Acid and Carvacrol Counteract Aluminium-Induced Oxidative Stress

et al. 2020

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“…Oleracein E ( 403 ) has a rare tetrahydroisoquinoline/pyrrolidone tricyclic skeleton and a catechol moiety 300 . It improved cognitive function, reversed abnormal brain antioxidant biomarkers (GSH, T‐AOC, MDA, and SOD) to normal levels, and inhibited hippocampal neuronal apoptosis in d ‐galactose/NaNO 2 ‐induced senescent mice and in some apoptotic indices induced by AlCl 3 301,302 …”

Section: Bioactivitiesmentioning

confidence: 99%

Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

133

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Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014-2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti-inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.

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“…16,17 Oleracin E 3 has been established as an antioxidant and antidepressant agent. 18,19 The catechol-derived tetrahydroisoquinoline alkaloid Salsolinol 4 plays an important role in pathogenic treatment associated with Parkinson's diseases. 20−23 Despite thienoquinolines and thienoisoquinolines being poorly represented in nature, they are important compounds in medicinal chemistry.…”

Section: ■ Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Activity of Novel Piperidinyl Tetrahydrothieno[2,3-c]isoquinolines and Related Heterocycles

et al. 2019

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A novel series of 1-amino-2-substituted-5- piperidinyl-6,7,8,9-tertahydrothieno[2,3-c]isoquinolines (4a−e) was synthesized upon treatment of 4-cyano-1-piperidinyl-5,6,7,8-tetrahydroisoquinline-3(2H)-thione (2) with α-halo carbonyl compounds such as chloroacetone, ethyl chloroacetate, 2-bromoacetophenone, chloroacetamide, and chloroacetanilide. Construction the pyrrolyl ring associated with the thienotetrahydroisoquinoline moiety was achieved by treatment of compounds 4a, b with 2,5-dimethoxytertahydrofuran in acetic acid. 1-Pyrrolyl-2-substituted-thieno[2,3-c]isoquinolines 5a and 5b which in turn were used as multipurpose precursors for synthesis of other new heterocycles. Assignments of the chemical structures of the respectively synthesized thienotetrahydroisoquinolines and their derivatives were established on the bases of elemental and spectral techniques (Fourier transform infrared, 1 H NMR, 13 C NMR, and mass spectroscopy). Furthermore, certain compounds were screened for their antimicrobial activity which revealed promising activities against various pathogenic strains of bacteria and fungi.

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Phenolic alkaloid oleracein E attenuates oxidative stress and neurotoxicity in AlCl3-treated mice

Cited by 17 publications

References 28 publications

Natural Compounds Rosmarinic Acid and Carvacrol Counteract Aluminium-Induced Oxidative Stress

Natural Compounds Rosmarinic Acid and Carvacrol Counteract Aluminium-Induced Oxidative Stress

Biologically active isoquinoline alkaloids covering 2014–2018

Synthesis and Antimicrobial Activity of Novel Piperidinyl Tetrahydrothieno[2,3-c]isoquinolines and Related Heterocycles

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