Pheniramines and Oxidative Burst of Blood Phagocytes During Ischaemia/Reperfusion

Nosáľ, R; Jančinová, Viera; Nosál'ová, Viera; Perečko, Tomáš; M, Cíz; Lojek, Antonı́n

doi:10.1007/s00011-009-2010-6

Cited by 4 publications

(7 citation statements)

References 7 publications

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“…The difference between pheniramines might result from their halogenisation, as demonstrated by inhibition of oxidative burst of blood phagocytes during ischaemia/reperfusion (Jančinová et al 2006;Nosáľ et al 2009b;Nosáľová et al 2009). Pheniramines, on the other side, decrease extracellular CL, which might indicate their ability to minimise the decrease in regulation of neutrophil functions and in microbial killing (Jančinová et al 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Histamine did not affect stimulated whole blood CL. The difference between particular H 1 antihistamines resulted from the physico-chemical properties of particular drugs rather than from their specificity to affect histamine receptors, as demonstrated in platelets and neutrophils (Jančinová et al 1995;Králová et al 2009), as well as in the inhibition of ischaemia/reperfusion damage of vessels (Nosáľ et al 2009b;Nosáľová et al 2009). The non-receptor interaction of H 1 -antihistamines with oxidative burst was most probably due to their cationic amphiphilic structure (Nosáľ et al 2009a), underlying their ability to scavenge free radicals extracellularly and their ability to pass neutrophil membranes intracellularly.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, H 1 -antihistamines were found to improve ischaemia/reperfusion injury in rat mesenteric microcirculation by suppressing oxidative burst of blood phagocytes, particularly neutrophils (Nosáľ et al 2009b;Nosáľová et al 2009). Differences in the effect of H 1 -antihistamines on oxidative burst and nitric oxide production of professional phagocytes depend on their physico-chemical properties and are related to the dissociation rate at acidic pH (Gillard and Chatelain 2006;Králová et al 2008Králová et al , 2009).…”

Section: Introductionmentioning

confidence: 98%

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Molecular pharmacology of antihistamines in inhibition of oxidative burst of professional phagocytes

Nosáľ¹,

Jancinová²,

Drábiková³

et al. 2015

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Antihistamines of the H 1 and H 3 /H 4 groups interfere with oxidative burst of human professional phagocytes in vitro. In the concentration of 10 μM, H 1 antihistamines of the 1 st and 2 nd generation inhibited oxidative burst of human neutrophils in the rank order of potency: dithiaden > loratadine > brompheniramine > chlorpheniramine > pheniramine. Of the H 1 antihistamines, the most effective was dithiaden in suppressing oxidative burst of whole human blood and dosedependently the chemiluminescence of isolated neutrophils at extra-and intracellular level. Inhibition of free oxygen radical generation in isolated neutrophils by dithiaden resulted from the inhibition of protein kinase C activation. The potentiation of recombinant caspase-3 by dithiaden is supportive of the antiinflammatory effect of dithiaden and suggestive of increasing the apoptosis of professional phagocytes. Of the H 3 /H 4 antihistamines, the most effective was JNJ7777120 in decreasing chemiluminescence in whole blood and also at extra-and intracellular sites of isolated neutrophils. JNJ 10191584 and thioperamide were less effective and the latter significantly potentiated free oxygen radical generation intracellularly. The results demonstrated that, compared with the H 3 /H 4 antihistamines investigated, H 1 antihistamines were much more potent in inhibiting free oxygen radical generation in human professional phagocytes. This finding should be taken into account therapeutically.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Molecular pharmacology of antihistamines in inhibition of oxidative burst of professional phagocytes

Nosáľ¹,

Jancinová²,

Drábiková³

et al. 2015

gpb

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“…Occlusion of the nutrient artery selectively is a frequently used method to assess the I/R injury to the target tissue. [10][11][12][14][15][16] As an alternative, I/R injury to the target tissue after period of ischemia created away from the target tissue was again investigated in various studies. 1,3,6,13 Ischemia of the lower extremity is inevitably seen in our routine peripheral vascular surgical practice.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Protective Effects of Pheniramine Maleate on Reperfusion Injury in Lung After Distant Organ Ischemia

Gokalp

Yurekli

Kıray

et al. 2013

Vasc Endovascular Surg

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“…We demonstrated that brains of the rats of the study and sham groups were subjected to reperfusion injury when compared with that of the control group. It was previously reported in several studies that glucocorticoids inhibited lipid peroxidation and production of free radicals; thus reducing I/R injury in many organs [3,5–7,15,21,22]. Some authors argued that these effects appeared in high doses [6,15], whereas some authors argued that these effects appeared even in low doses [8,21,22].…”

Section: Discussionmentioning

confidence: 99%

Effect of pheniramine maleate on reperfusion injury in brain tissue

Yurekli

Gokalp

Kıray

et al. 2013

Med Sci Monit Basic Res

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BackgroundThe aim of this study was to investigate the protective effects of methylprednisolone (Pn), which is a potent anti-inflammatory agent, and pheniramine maleate (Ph), which is an antihistaminic with some anti-inflammatory effects, on reperfusion injury in brain developing after ischemia of the left lower extremity of rats.Material/MethodsTwenty-eight randomly selected male Sprague-Dawley rats were divided into 4 groups: Group 1 was the control group, Group 2 was the sham group (I/R), Rats in Group 3 were subjected to I/R and given Ph, and rats in Group 4 were subjected to I/R and given Pn. A tourniquet was applied at the level of left groin region of subjects in the I/R group after induction of anesthesia. One h of ischemia was performed with no drug administration. In the Ph group, half of a total dose of 10 mg/kg Ph was administered intraperitoneally before ischemia and the remaining half before reperfusion. In the Pn group, subjects received a single dose of 50 mg/kg Pn intraperitoneally at the 30th min of ischemia. Brains of all subjects were removed after 24 h for examination.ResultsMalondialdehyde (MDA) levels of the prefrontal cortex were significantly lower in the Ph group than in the I/R group (p<0.05). Superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzyme activities were found to be significantly higher in the Ph group than in the I/R group (p<0.05). Histological examination demonstrated that Ph had protective effects against I/R injury developing in the brain tissue.ConclusionsPh has a protective effect against ischemia/reperfusion injury created experimentally in rat brains.

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Pheniramines and Oxidative Burst of Blood Phagocytes During Ischaemia/Reperfusion

Cited by 4 publications

References 7 publications

Molecular pharmacology of antihistamines in inhibition of oxidative burst of professional phagocytes

Molecular pharmacology of antihistamines in inhibition of oxidative burst of professional phagocytes

Assessment of Protective Effects of Pheniramine Maleate on Reperfusion Injury in Lung After Distant Organ Ischemia

Effect of pheniramine maleate on reperfusion injury in brain tissue

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