Phellinus linteus mushroom protects against tacrine-induced mitochondrial impairment and oxidative stress in HepG2 cells

Gao, Chunpeng; Zhong, Laifu; Jiang, Liping; Chen, Geng; Yao, Xiaofeng; Cao, Jun

doi:10.1016/j.phymed.2013.02.014

Cited by 19 publications

(15 citation statements)

References 24 publications

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“…Two studies by Gao et al (, ) shed new light on the process of tacrine‐triggered apoptosis. A study published in 2013 found that tacrine induced cytotoxicity and mitochondria dysfunction by reactive oxygen species generation and 8‐oxo‐2′‐deoxyguanosine formation in the mitochondrial DNA of HepG2 cells.…”

Section: Cytotoxicity Of Tacrine and Its Derivativesmentioning

confidence: 99%

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Multifunctional properties of novel tacrine congeners: cholinesterase inhibition and cytotoxic activity

Sabolová¹,

Kristián

Kožurková

2018

J of Applied Toxicology

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This review describes the synthesis of a wide range of novel tetrahydroacridine derivatives (tiocyanates, selenocyanates, ureas, selenoureas, thioureas, isothioureas, disulfides, diselenides and several tacrine homo- and hetro-hybrids). These tacrine congeners exhibit significant anticholinesterase and cytotoxic properties and may therefore be of considerable potential for the development of new drugs for the treatment of Alzheimer's disease.

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Section: Cytotoxicity Of Tacrine and Its Derivativesmentioning

confidence: 99%

“…The delayed toxicity of tacrine may be explained by examining the progressive effects of the agent on DNA, and therefore Mansouri Two studies by Gao et al (2013Gao et al ( , 2014…”

Section: Cytotoxic Properties Of Tacrinementioning

confidence: 99%

Multifunctional properties of novel tacrine congeners: cholinesterase inhibition and cytotoxic activity

Sabolová¹,

Kristián

Kožurková

2018

J of Applied Toxicology

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“…Hepatoprotective activities, including anti-hepatitis, anti-hepatocarcinoma and anti-alcoholism, of mushroom Antrodia cinnamomea have been demonstrated both in vitro and in vivo [94]. In addition, consumption of mushroom Phellinus linteus could prevent tacrine-induced hepatotoxicity [95].…”

Section: Other Bioactivities Of Mushroomsmentioning

confidence: 99%

Bioactivities and Health Benefits of Mushrooms Mainly from China

et al. 2016

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Many mushrooms have been used as foods and medicines for a long time. Mushrooms contain polyphenols, polysaccharides, vitamins and minerals. Studies show that mushrooms possess various bioactivities, such as antioxidant, anti-inflammatory, anticancer, immunomodulatory, antimicrobial, hepatoprotective, and antidiabetic properties, therefore, mushrooms have attracted increasing attention in recent years, and could be developed into functional food or medicines for prevention and treatment of several chronic diseases, such as cancer, cardiovascular diseases, diabetes mellitus and neurodegenerative diseases. The present review summarizes the bioactivities and health benefits of mushrooms, and could be useful for full utilization of mushrooms.

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“…The polysaccharides of mushrooms were proven to be an effective ingredient for the treatment of diseases such as lung cancer and colorectal carcinoma ( 5 ). In addition to mushroom polysaccharides, other polysaccharides isolated from natural materials have also been demonstrated to prevent ailments including gastroenteric dysfunction, diarrhea and cancer ( 6 , 7 ).…”

Section: Introductionmentioning

confidence: 99%

Antitumor and immunomodulating activities of six Phellinus igniarius polysaccharides of different origins

et al. 2017

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The aim of the current study was to compare the antitumor efficiency of Phellinus igniarius polysaccharides (PIP) from six different origins and preliminarily investigate its potential mechanisms. PIP was extracted using the microwave extraction method. The corresponding in vivo antitumor efficacy was assessed in Kunming mice bearing H22 tumors and Gansu PIP (GPIP) was identified to have a significantly higher antitumor efficacy compared with the control group (P<0.05), while no significant difference was observed following treatment with PIP from different origins (P>0.05). The spleen index of the GPIP group significantly increased compared with the saline and CTX groups (P<0.01). The in vitro MTT assay of GPIP on HepG2 cells indicated that GPIP had no direct cytotoxicity. The serum immune cytokines of interleukin-2, interleukin-12 and interferon-γ were assessed using the ELISA method. The concentration of all three serum cytokines significantly increased compared with saline and CTX groups (P<0.01) indicating that activating the immune system may be a potential antitumor mechanism. These results demonstrated that GPIP has great potential as a natural antitumor agent with immunomodulatory activity.

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Phellinus linteus mushroom protects against tacrine-induced mitochondrial impairment and oxidative stress in HepG2 cells

Cited by 19 publications

References 24 publications

Multifunctional properties of novel tacrine congeners: cholinesterase inhibition and cytotoxic activity

Multifunctional properties of novel tacrine congeners: cholinesterase inhibition and cytotoxic activity

Bioactivities and Health Benefits of Mushrooms Mainly from China

Antitumor and immunomodulating activities of six Phellinus igniarius polysaccharides of different origins

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