Bioactivities and Health Benefits of Mushrooms Mainly from China

Zhang, Jiaojiao; Li, Ya; Zhou, Tong; Xu, Dong-ping; Zhang, Pei; Li, Sha; Li, Hua-Bin

doi:10.3390/molecules21070938

Cited by 121 publications

(107 citation statements)

References 108 publications

(112 reference statements)

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“…The consequences are the augmentation of the intracellular arachidonic acid level, malondialdehyde formation, and alteration in cellular calcium and glutathione levels, resulting in cellular oxidative damage [5,6]. Bioactive compounds derived from edible plants capable of quenching free radicals or preserving cell membrane integrity are of great interest in combating oxidative stress-induced cellular damage [7,8]. So, plant bioactive compounds such as phenolics, flavonoids, anthocyanins, and vitamins may exert various biological activities on cells [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Bioactive compounds derived from edible plants capable of quenching free radicals or preserving cell membrane integrity are of great interest in combating oxidative stress-induced cellular damage [7,8]. So, plant bioactive compounds such as phenolics, flavonoids, anthocyanins, and vitamins may exert various biological activities on cells [8,9]. These compounds could prevent free-radical-mediated cellular oxidative damage by quenching the free radicals and by trapping the free metals.…”

Section: Introductionmentioning

confidence: 99%

“…These compounds could prevent free-radical-mediated cellular oxidative damage by quenching the free radicals and by trapping the free metals. In addition, the polyphenols of fruits could modulate the membrane permeability and limit the incorporation of deleterious compounds that could affect cell membrane integrity [8]. …”

Section: Introductionmentioning

confidence: 99%

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Human Lymphocyte-Protective Effects of an Ethanol Extract from Detarium microcarpum Guill. and Perr. (Caesalpiniaceae) Fruit Pulp

et al. 2018

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The current study aimed to evaluate, in vitro, the antioxidant capacity and the human lymphocyte-protective effect of the ethanolic extract from Detarium microcarpum fruit pulp against oxidative stress damage. Human lymphocytes were incubated with different concentrations of extract, followed by the addition of hydrogen peroxide or tert-butyl hydroperoxide. Cell viability was measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Furthermore, the antioxidant property of the extract was evaluated in vitro using hydrogen peroxide and nitric oxide radical-scavenging assays. Compared to the vehicle, the fruit pulp ethanol extract did not exhibit a cytotoxic effect on human lymphocytes. Furthermore, the cytotoxicity of hydrogen peroxide and tert-butyl hydroperoxide to human lymphocytes was significantly reduced by fruit extract pretreatment. The extract and ascorbic acid exhibited similar cytoprotective activity (p > 0.05). The fruit pulp extract showed more antioxidant activity than gallic acid in the hydrogen peroxide-scavenging model, while in the nitric oxide-quenching model, the fruit extract and gallic acid showed similar activity. The fruit pulp of D. microcarpum contains potent antioxidant and cell-protective compounds. The use of the fruit pulp of D. microcarpum as a food supplement could rescue cellular oxidative damage responsible for numerous pathologies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Human Lymphocyte-Protective Effects of an Ethanol Extract from Detarium microcarpum Guill. and Perr. (Caesalpiniaceae) Fruit Pulp

et al. 2018

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“…Medicinal properties -Cordyceps militaris is one of the most valuable medicinal mushrooms and neutraceuticals in China (Zhang et al 2016). It is an asexual morph of Ophiocordyceps sinensis commonly used as a substitute of the natural Cordyceps (Li et al 2006).…”

Section: Cordycipitaceaementioning

confidence: 99%

Healing mushrooms of Uttarakhand Himalaya, India

Bhatt¹

2018

CREAM

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The Himalayan forests of Uttarakhand represent a natural repository for the rich biodiversity of the Indian subcontinent. Forest resources in this region form an integral part of socio-economy and cultural practices. Mushrooms are forest products which have been used as food for a long time but very few for therapeutic purposes, which is associated to the lack of awareness and knowledge. If properly identified, these mystic organisms can be very promising in prevention and cure of various ailments. The present study is a part of macrofungal exploration carried out from 2015-2016. As a result, 15 mushroom species are identified which possess a spectrum of bioactive compounds and therapeutic potential. All of these species are morphologically described along with the habit, habitat and notes on their healing capacities.

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“…The historic use of mushrooms as traditional medicine originated in the far east, and is currently attracting a lot of interest worldwide as mushroom metabolites (organic compounds not directly involved for growth, development and reproduction of the organism) are deemed safe and can be incorporated into our diet without the need to undergo lengthy clinical trials (Lull et al 2005;Seca & Pinto, 2018). The potential of mushrooms as therapeutics is huge, with many known to exhibit myriad biological activities such as anti-cancer, anti-diabetic, anti-hypercholesterolemia, anti-hypertensive, anti-inflammatory, anti-microbial, antioxidant, immuno-modulatory, and liverprotective activities (Zhang et al, 2016). Mushrooms have been used as food and medicines since ancient times (Wasser, 2014).…”

Section: Medicinal Mushrooms and Their Role In Treating Cancermentioning

confidence: 99%

Purification and characterization of an immuno-stimulatory compound from the water extract of royoporus badius (Pers.) A.B. De.

Lim¹

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A novel immuno-stimulatory polysaccharide-protein complex (ISPP-Rb) was isolated from Royoporus badius sporocarps, collected in northern BC forests. ISPP-Rb was purified from the water extract of R. badius using anion-exchange and size-exclusion chromatography and could significantly activate murine macrophage (RAW 264.7) cells. ISPP-Rb is highly branched and has an average molecular weight of 400 kDa. GC-MS data suggest the polysaccharide component of ISPP-Rb has a backbone of (1 → 6)-Gal/Man and (1 → 2,6)-Glc, with the latter being attached to either glucose, galactose or fucose at its terminal end. The protein component, found to be indispensable for its immuno-stimulatory activity, is proposed to link to a mannose residue via Olinked glycosylation. ISPP-Rb was able to induce various proinflammatory cytokines including TNF-α, IP-10, MIP-2, G-CSF, GM-CSF, MIP-1α, and MIP-1β. This is the first immunostimulatory compound to be reported from R. badius, and hence making ISPP-Rb novel.iii

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Bioactivities and Health Benefits of Mushrooms Mainly from China

Cited by 121 publications

References 108 publications

Human Lymphocyte-Protective Effects of an Ethanol Extract from Detarium microcarpum Guill. and Perr. (Caesalpiniaceae) Fruit Pulp

Human Lymphocyte-Protective Effects of an Ethanol Extract from Detarium microcarpum Guill. and Perr. (Caesalpiniaceae) Fruit Pulp

Healing mushrooms of Uttarakhand Himalaya, India

Purification and characterization of an immuno-stimulatory compound from the water extract of royoporus badius (Pers.) A.B. De.

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