PHBV/PLLA-based composite scaffolds containing nano-sized hydroxyapatite particles for bone tissue engineering

Sultana, Naznin; Wang, Min

doi:10.1080/17458080701867429

Cited by 41 publications

(36 citation statements)

References 27 publications

(35 reference statements)

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“…The technique has found increasing interest in the last years for fabrication of highly porous scaffolds with interconnected and tailored architecture [82][83][84]. This process has been investigated by a number of research groups pursuing the fabrication of polymer matrix composites with the incorporation of inorganic phases such as HA [82,83], demineralized bone [85], calcium phosphates [86,87], and bioactive glass particles [88][89][90][91].…”

Section: Composite Scaffolds By Freeze-dryingmentioning

confidence: 99%

Bioactive Glass-Biopolymer Composites for Applications in Tissue Engineering

Ding¹,

Souza²,

Li³

et al. 2016

Handbook of Bioceramics and Biocomposites

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Section: Composite Scaffolds By Freeze-dryingmentioning

confidence: 99%

Bioactive Glass-Biopolymer Composites for Applications in Tissue Engineering

Ding¹,

Souza²,

Li³

et al. 2016

Handbook of Bioceramics and Biocomposites

View full text Add to dashboard Cite

Section: Composite Scaffolds By Freeze-dryingmentioning

confidence: 99%

Bioactive Glass-Biopolymer Composites

Ding¹,

Souza²,

Li³

et al. 2015

Handbook of Bioceramics and Biocomposites

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Tissue engineering (TE) is a biomedical field in continuous expansion. However, there are still many challenges, and the further development of TE approaches requires interdisciplinary interaction and collaboration among various research areas with a notable contribution expected from biomaterials science. In the last couple of decades, significant advances in the development of biomaterial-based scaffolds for hard and soft tissue regeneration have been accomplished, including the manufacture of biocomposites that combine natural or synthetic polymers with bioactive glasses or glass-ceramics. These novel biomaterials present the possibility of tailoring a variety of parameters and properties such as degradation kinetics, mechanical properties, and chemical composition according to the aimed application. This chapter presents a concise update of the field of biopolymer-bioactive glass composite scaffold development for TE covering several popular processing techniques for biocomposite fabrication, namely, microsphere processing, solvent casting-particulate leaching method, electrospinning, freezedrying, and rapid prototyping techniques, which lead to scaffolds exhibiting a variety of 3D morphologies and different pore structures.

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“…PHBV has been investigated for tissue engineering application [3][4][5]. Due to the slow degradation rate, PHBV can be blended with PLLA in order to control degradation rate and time [6,7]. Hydroxyapatite (HA) being the mineral component of living bones has gained much recognition as a scaffolding material [8,9].…”

Section: Introductionmentioning

confidence: 99%

Factorial Study of Compressive Mechanical Properties and PrimaryIn VitroOsteoblast Response of PHBV/PLLA Scaffolds

Sultana

Khan

2012

Journal of Nanomaterials

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For bone tissue regeneration, composite scaffolds containing biodegradable polymers and nanosized osteoconductive bioceramics have been regarded as promising biomimetic systems. Polymer blends of poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) and poly(L-lactic acid) (PLLA) can be used as the polymer matrix to control the degradation rate. In order to render the scaffolds osteoconductive, nano-sized hydroxyapatite (nHA) particles can be incorporated into the polymer matrix. In the first part of this study, a factorial design approach to investigate the influence of materials on the initial compressive mechanical properties of the scaffolds was studied. In the second part, the protein adsorption behavior and the attachment and morphology of osteoblast-like cells (Saos-2) of the scaffoldsin vitrowere also studied. It was observed that nHA incorporated PHBV/PLLA composite scaffolds adsorbed more bovine serum albumin (BSA) protein than PHBV or PHBV/PLLA scaffolds.In vitrostudies also revealed that the attachment of human osteoblastic cells (SaOS-2) was significantly higher in nHA incorporated PHBV/PLLA composite scaffolds. From the SEM micrographs of nHA incorporated PHBV/PLLA composite scaffolds seeded with SaOS-2 cells after a 7-day cell culture period, it was observed that the cells were well expanded and spread in all directions on the scaffolds.

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PHBV/PLLA-based composite scaffolds containing nano-sized hydroxyapatite particles for bone tissue engineering

Cited by 41 publications

References 27 publications

Bioactive Glass-Biopolymer Composites for Applications in Tissue Engineering

Bioactive Glass-Biopolymer Composites for Applications in Tissue Engineering

Bioactive Glass-Biopolymer Composites

Factorial Study of Compressive Mechanical Properties and PrimaryIn VitroOsteoblast Response of PHBV/PLLA Scaffolds

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