This paper investigated the long-termin vitrodegradation properties of scaffolds based on biodegradable polymers and osteoconductive bioceramic/polymer composite materials for the application of bone tissue engineering. The three-dimensional porous scaffolds were fabricated using emulsion-freezing/freeze-drying technique using poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) which is a natural biodegradable and biocompatible polymer. Nanosized hydroxyapatite (nHA) particles were successfully incorporated into the PHBV scaffolds to render the scaffolds osteoconductive. The PHBV and nHA/PHBV scaffolds were systematically evaluated using various techniques in terms of mechanical strength, porosity, porous morphology, andin vitrodegradation. PHBV and nHA/PHBV scaffolds degraded over time in phosphate-buffered saline at 37°C. PHBV polymer scaffolds exhibited slow molecular weight loss and weight loss in thein vitrophysiological environment. Accelerated weight loss was observed in nHA incorporated PHBV composite scaffolds. An increasing trend of crystallinity was observed during the initial period of degradation time. The compressive properties decreased more than 40% after 5-monthin vitrodegradation. Together with interconnected pores, high porosity, suitable mechanical properties, and slow degradation profile obtained from long-term degradation studies, the PHBV scaffolds and osteoconductive nHA/PHBV composite scaffolds showed promises for bone tissue engineering application.
The application of qualitative techniques is increasing and acceptable among the researchers. However, majority of the researchers and postgraduate students did not consider the importance of giving detailed procedures in qualitative data analysis for better understanding of the qualitative results. There is a need to uncover step by step approach in qualitative analysis for better application of qualitative techniques. This article presented a detailed step-by-step approach for qualitative analysis with the aid of a pragmatic illustration. The analytic process presented employed the example of qualitative data transcribed into narrative data to develop basic themes. The employment of Domain Analysis and Thematic Network analysis in the example given helped basic themes to converge to higher order themes. The article submitted that this approach in qualitative analysis will aid thorough understanding of qualitative data interpretation. This is extremely thoughtful approach for the systematic presentation of qualitative analysis.
Communications related to architectural projects have become more complicated due to more complex design projects, the growth of technology and design information management systems and different backgrounds of stakeholders. These issues have had a significant effect on how buildings are designed and evolved Architecture to combine technical and social aspects of design. This study reviewed and focused in Design and facilities management, behavior and communication as well as interfaces issues. This study introduced the approaches and strategic methods of effective communication in architectural design practice from the view of technological and humanistic characteristics to manage communication challenges in architect-client relationship.
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