-Phasic Model of xytocin (): A systematic conceptual review of oxytocin-related ERP research

Pehlivanoglu, Didem; Myers, Elisha; Ebner, Natalie C.

doi:10.1016/j.biopsycho.2020.107917

Cited by 7 publications

(7 citation statements)

References 119 publications

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“…This tri‐phasic response consisted of three differential components (P1, N1 and P2), rather than ERP components, as these components already reflect the contrast between the neutral faces and the expressive faces (Dzhelyova & Rossion, 2014b). One might argue that the time‐locked waveforms elicited by these facial expressions may overlap with the tri‐phasic OXT‐related ERP modulation, as proposed by Pehlivanoglu et al (2020). According to these authors, the ERP modulation effect of OXT starts in the perception stage (100–200 ms), where it enhances the perceived salience of stimuli.…”

Section: Discussionmentioning

confidence: 94%

“…According to these authors, the ERP modulation effect of OXT starts in the perception stage (100–200 ms), where it enhances the perceived salience of stimuli. Second, during the selection stage (200–300 ms), OXT is thought to facilitate attention toward social stimuli, and, third, during the evaluation stage (>300 ms), the OXT‐induced increased sustained attention to motivationally salient information converts to higher‐order cognitive processing (Pehlivanoglu et al, 2020). While the time‐windows defined in our study may map perfectly on these postulated latency‐dependent OXT modulatory stages, the selection of our time‐windows was based on the average waveform of OXT and PL combined.…”

Section: Discussionmentioning

confidence: 99%

“…Mechanistic models suggest that OXT may exert its complex social effects by regulating the saliency of social cues and/or by modulating (social) stress and anxiety (Churchland & Winkielman, 2012; Pehlivanoglu et al, 2020; Shamay‐Tsoory & Abu‐Akel, 2016). As these effects can be of particular interest for facial emotion processing, many behavioral studies have sought to elucidate how OXT affects this ability.…”

Section: Introductionmentioning

confidence: 99%

“…To date, few studies have investigated the effects of a single dose of OXT on facial emotion processing using electroencephalography (EEG) (for a review, see Pehlivanoglu et al, 2020). Event-related potential (ERP) studies investigating the modulatory effect of OXT reported shorter latencies of the N170 component (Tillman et al, 2019), as well as increased amplitudes of the N170 (Peltola et al, 2018) and the vertex positive potential (VPP; Huffmeijer et al, 2013), indicating enhanced sensitivity and improved neural efficiency to process emotional faces.…”

Section: Introductionmentioning

confidence: 99%

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Monitoring the effect of oxytocin on the neural sensitivity to emotional faces via frequency‐tagging EEG: A double‐blind, cross‐over study

et al. 2022

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The neuropeptide oxytocin (OXT) is suggested to exert an important role in human social behaviors by modulating the salience of social cues. To date, however, there is mixed evidence whether a single dose of OXT can improve the behavioral and neural sensitivity for emotional face processing. To overcome difficulties encountered with classic event-related potential studies assessing stimulus-saliency, we applied frequency-tagging EEG to implicitly assess the effect of a single dose of OXT (24 IU) on the neural sensitivity for positive and negative facial emotions.Neutral faces with different identities were presented at 6 Hz, periodically interleaved with an expressive face (angry, fearful, and happy, in separate sequences) every fifth image (i.e., 1.2 Hz oddball frequency). These distinctive frequency tags for neutral and expressive stimuli allowed direct and objective quantification of the neural expression-categorization responses. The study involved a doubleblind, placebo-controlled, cross-over trial with 31 healthy adult men. Contrary to our expectations, we did not find an effect of OXT on facial emotion processing, neither at the neural, nor at the behavioral level. A single dose of OXT did not evoke social enhancement in general, nor did it affect social approach-avoidance tendencies. Possibly ceiling performances in facial emotion processing might have hampered further improvement.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Monitoring the effect of oxytocin on the neural sensitivity to emotional faces via frequency‐tagging EEG: A double‐blind, cross‐over study

et al. 2022

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“…Existing evidence suggests that oxytocin serum levels play a role in many aspects of social behavior, improving bonding and attachment [ 13 – 15 ] increasing willingness to share emotions [ 16 ], positive communication [ 17 ] and trust [ 18 , 19 ] increasing the ability to interpret mental states [ 20 ] and modulating the attentional processes [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Depressive symptomatology, temperament and oxytocin serum levels in a sample of healthy female university students

et al. 2022

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Background Depressive symptomatology is prevalent among female university students with adverse effects on their quality of life and academic performance. Previous research suggested associations between depressive symptomatology and oxytocin levels and between depressive symptomatology and Temperament Traits. Despite this evidence, to the best of our knowledge no research has studied the effects fboth oxytocin serum levels and temperament dimensions on depressivesymptoms in a healthy sample. The present study aimed to analyse the effect of oxytocin levels and temperament traits on depressive symptomatology in healthy female university students. Methods All participants completed the Beck Depression Inventory and the Adult Temperament Questionnaire. Blood samples were collected between 8 and 8H30 a.m. after 12 h of fasting and between 5 and 8 day of the menstrual cycle and serum oxytocin levels were quantified using a commercial enzyme-linked immunosorbent assay. A hierarchical multiple regression model using a stepwise method was conducted to identify predictors of depression. Results Forty-five women aged between 18 and 25 years old (19.37 ± 1.32 years) volunteered to participate in this study. Depressive symptomatology was negatively associated with oxytocin serum levels and "Negative affect" and positively associated with "Effortful control" and "Activation Control". In the final regression model, only oxytocin level was a predictor (B = − 0.090, p < 0.0001), the model explaining 65.2% of the depression variation. Oxytocin played a mediation role between "Negative affects" and Depressive symptomatology. Conclusions Our results showed that oxytocin level, rather than personality dimensions, was associated with depressive symptomatology. These results highlight the relevance of the discussion on the use of oxytocin as a biological marker of emotional and social symptoms that characterize depression.

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The Role of Intranasal Oxytocin on Social Cognition: an Integrative Human Lifespan Approach

Horta

Pehlivanoglu

Ebner

2020

Curr Behav Neurosci Rep

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-Phasic Model of xytocin (): A systematic conceptual review of oxytocin-related ERP research

Cited by 7 publications

References 119 publications

Monitoring the effect of oxytocin on the neural sensitivity to emotional faces via frequency‐tagging EEG: A double‐blind, cross‐over study

Monitoring the effect of oxytocin on the neural sensitivity to emotional faces via frequency‐tagging EEG: A double‐blind, cross‐over study

Depressive symptomatology, temperament and oxytocin serum levels in a sample of healthy female university students

The Role of Intranasal Oxytocin on Social Cognition: an Integrative Human Lifespan Approach

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