Phase transition and release kinetics of polyphenols encapsulated lyotropic liquid crystals

Zhang, Heng; Wang, Zhongni

doi:10.1016/j.ijpharm.2019.05.021

Cited by 23 publications

(4 citation statements)

References 39 publications

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“…Based on the diffusion exponent (n), the emulsions presented anomalous transport (non-fickian) mechanism for drug release [40]. These values suggest that the release was synergistically controlled by an anomalous diffusion mechanism of mass transport and polymer relaxation, such as matrix swelling, due to the presence of a polymeric microgel network (polyacrylate) [41][42][43]. Otherwise, in this particular study, the size of drug particles was not determinant since there is no plateau effect in release.…”

Section: In Vitro Khe Releasementioning

confidence: 71%

Development of Gel-in-Oil Emulsions for Khellin Topical Delivery

et al. 2020

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Hypopigmentation is a progressive dermatological condition caused by a reduction in the skin pigment, melanin. Its treatment is considered a challenge due to the lack of a highly efficient single therapy. Currently, the main treatments include photochemotherapy, application of corticosteroids and immunosuppressants, and laser. Khellin-based gel-in-oil emulsions appear as a promising alternative since they ensure a concentration of the drug, a natural furanochromone, at the desired location, skin surface. Khellin promotes repigmentation as it forms a dark colored complex after solar irradiation. The aim of this study was the development and characterization (e.g., rheological behaviour, droplet size, tackiness, adhesion and spreadability) of three topical gel-in-oil emulsions prepared with different emollients, formulated through a cold emulsification process, and suitable for the incorporation of khellin. In vitro studies were performed to evaluate the drug release and permeation profiles across artificial membranes and excised human skin, respectively, using Franz-type vertical diffusion cells. The W/O emulsions developed showed macroscopic appearance, shear-thinning behavior with a mean droplet size from 3.28 to 4.28 μm, suitable for topical application. In vitro studies revealed permeation values of about 1% of khellin across the stratum corneum, making these gel-in-oil emulsions promising for preclinical and clinical studies. The cold process, being an easy and low energy production method, represents an innovative strategy to produce khellin-based gel-in-oil emulsions to treat patients with hypopigmentation.

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Section: In Vitro Khe Releasementioning

confidence: 71%

Development of Gel-in-Oil Emulsions for Khellin Topical Delivery

et al. 2020

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“…The time required for cumulative release to reach 50% ( T 50% ) was used as a criterion for evaluating the release rate. 47 The T 50% in ethanol solution, the traditional emulsion with HSO, and liquid crystal emulsion with and without HSO crystal were 77.3, 144.18, 212.3, and 138.8 min, respectively. Clearly, either the liquid crystal or HSO crystal in the system had a sustainable release effect on vitamin E. The liquid crystal emulsion containing HSO crystals showed a more significant sustainable release behavior for vitamin E compared with the liquid crystal emulsion without HSO crystal and traditional emulsion containing HSO crystals.…”

Section: Resultsmentioning

confidence: 92%

Novel delivery system: a liquid crystal emulsion containing HSO crystals

Ding

Chen

et al. 2023

New J. Chem.

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“…As the implementation of formulations with additional components can modify the physical characteristics of the resulting cubic phase, this event also has a non-negligible impact on the LLCs’ three-dimensional structures. There is a strong interest among researchers in the effects deriving from the incorporation of additives in LLC formulations, as this could involve changes in the rheological behavior of mesophases, favor the transition from one phase to another or even enable them to coexist [ 26 , 27 ].…”

Section: Resultsmentioning

confidence: 99%

In Situ Swelling Formulation of Glycerol-Monooleate-Derived Lyotropic Liquid Crystals Proposed for Local Vaginal Application

et al. 2022

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Hydrogels have been extensively investigated to identify innovative formulations that can fulfill all the necessary purposes to improve local vaginal therapy through the mucosa. Herein, we propose in situ-forming lyotropic liquid crystals (LLCs) derived from a cheap and GRAS (generally recognized as safe) ingredient as an intravaginal delivery system. The system consists of a precursor solution loaded with sertaconazole nitrate as a model drug, which is able to easily swell in a stable three-dimensional structure by absorbing simulated vaginal fluid. Under polarized light microscopy the precursor solution and the formed phase of LLCs showed the typical textures belonging to anisotropic and an isotropic mesophases, respectively. A deep rheological investigation by Kinexus® Pro proved the stability and strength of the cubic phase, as well as its potential in mucoadhesion. In vitro degradation studies showed a slow matrix erosion, consistent with data obtained from lipophilic drug release studies in simulated vaginal fluid. Therefore, the suggested cubic phase based on lyotropic liquid crystals could represent a valid proposal as a vaginal drug delivery system due to its characteristics of resistance, adhesion and the possibility of providing a slow and controlled release of drugs directly at the administration site.

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Phase transition and release kinetics of polyphenols encapsulated lyotropic liquid crystals

Cited by 23 publications

References 39 publications

Development of Gel-in-Oil Emulsions for Khellin Topical Delivery

Development of Gel-in-Oil Emulsions for Khellin Topical Delivery

Novel delivery system: a liquid crystal emulsion containing HSO crystals

In Situ Swelling Formulation of Glycerol-Monooleate-Derived Lyotropic Liquid Crystals Proposed for Local Vaginal Application

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