Phase Separation Orchestrates Cancer Signaling: Stress Granules as a Promising Target for Cancer Therapy

Sugiura, Reiko; Satoh, Ryosuke; Tomimoto, Naofumi; Takasaki, Teruaki

doi:10.1007/978-981-99-4886-4_12

Phase Separation in Living Cells 2023

DOI: 10.1007/978-981-99-4886-4_12

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Phase Separation Orchestrates Cancer Signaling: Stress Granules as a Promising Target for Cancer Therapy

Reiko Sugiura,

Ryosuke Satoh,

Naofumi Tomimoto

et al.

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2024

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Biophysical Mechanisms of Liquid–Liquid Phase Separation in Biological Systems

Uzorka,

Olaniyan,

Bawa

2024

Biophys. Rev. Lett.

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A key biophysical process in biological systems, liquid–liquid phase separation (LLPS) is responsible for constructing membrane-less organelles and modulating cellular activities. The biophysical mechanisms underlying LLPS are explored in this paper, with an emphasis on multivalent interactions, entropy-driven processes, and how they affect cellular organization. We investigate the impact of external stimuli on phase behavior and clarify the physiological roles of biomolecular condensates, from stress response modulation to gene expression regulation. In addition, we study dysregulated LLPS in human disorders, providing information about possible therapeutic targets and approaches to innovative therapeutics. Through this interdisciplinary approach, we aim to improve our knowledge of LLPS and its effects on health and illness, opening the door to new therapeutic approaches that focus on the behavior of proteins and the structure of cells.

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Biophysical Mechanisms of Liquid–Liquid Phase Separation in Biological Systems

Uzorka,

Olaniyan,

Bawa

2024

Biophys. Rev. Lett.

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scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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Phase Separation Orchestrates Cancer Signaling: Stress Granules as a Promising Target for Cancer Therapy

Cited by 1 publication

References 273 publications

Biophysical Mechanisms of Liquid–Liquid Phase Separation in Biological Systems

Biophysical Mechanisms of Liquid–Liquid Phase Separation in Biological Systems

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