Biophysical Mechanisms of Liquid–Liquid Phase Separation in Biological Systems
Afam Uzorka,
Ademola Olatide Olaniyan,
Musa Bawa
Abstract:A key biophysical process in biological systems, liquid–liquid phase separation (LLPS) is responsible for constructing membrane-less organelles and modulating cellular activities. The biophysical mechanisms underlying LLPS are explored in this paper, with an emphasis on multivalent interactions, entropy-driven processes, and how they affect cellular organization. We investigate the impact of external stimuli on phase behavior and clarify the physiological roles of biomolecular condensates, from stress response… Show more
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