The Cramér-Rao bound and the quantum Fisher information (QFI) have been tools used extensively for the interferometric phase sensitivity. Most scenarios considering a Mach-Zehnder interferometer (MZI) with two input sources focused on the phase-matched case, when the Fisher information is maximal. Under this constraint, the best sensitivity is achieved for a balanced (50/50) input beam splitter. In this paper, we take a different approach: we allow the beam splitter transmission coefficient as well as the input phase mis-match to be variable parameters. We then search for a pair of these parameters that maximizes the Fisher information. We find that for the double coherent input the maximum Fisher information can always be reached in the unbalanced case for a carefully chosen input phase mis-match. For the coherent plus squeezed vacuum case we find that under certain circumstances, a threshold phase mis-match exists, beyond which the optimum Fisher information is found for the degenerate case. For the squeezed-coherent plus squeezed vacuum case we find that the optimum is actually when the squeezing angles of the two inputs are in anti-phase.