Phase morphology of hydrolysable polyurethanes derived from aqueous dispersions

Ayres, Eliane; Oréfice, Rodrigo Lambert; Yoshida, Mitsuhide

doi:10.1016/j.eurpolymj.2007.05.014

Cited by 93 publications

(50 citation statements)

References 18 publications

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“…The degree of microphase separation of segmented PURs can be determined from the extent of hydrogen bonding in the hard segments. This type of bonding can be monitored by ATR-FTIR as shifts in N-H and C@O stretching frequencies to lower values [30][31]. In Fig.…”

Section: Ftir Spectroscopymentioning

confidence: 99%

Optimization of the structure of polyurethanes for bone tissue engineering applications

et al. 2010

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Section: Ftir Spectroscopymentioning

confidence: 99%

Optimization of the structure of polyurethanes for bone tissue engineering applications

et al. 2010

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“…The hard segment improves mechanical properties by acting as reinforcing filler and as thermally reversible crosslink. The soft segment can favor the elastomeric character to the polymer backbone [1,2].…”

Section: Introductionmentioning

confidence: 99%

Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis

Pinto

Cunha

Oréfice

et al. 2012

J Mater Sci: Mater Med

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The purpose of this study was to develop triamcinolone acetonide-loaded polyurethane implants (TA PU implants) for the local treatment of different pathologies including arthritis, ocular and neuroinflammatory disorders. The TA PU implants were characterized by FTIR, SAXS and WAXS. The in vitro and in vivo release of TA from the PU implants was evaluated. The efficacy of TA PU implants in suppressing inflammatory-angiogenesis in a murine sponge model was demonstrated. FTIR results revealed no chemical interactions between polymer and drug. SAXS results indicated that the incorporation of the drug did not disturb the polymer morphology. WAXS showed that the crystalline nature of the TA was preserved after incorporation into the PU. The TA released from the PU implants efficiently inhibited the inflammatory-angiogenesis induced by sponge discs in an experimental animal model. Finally, TA PU implants could be used as local drug delivery systems because of their controlled delivery of TA.

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“…Additionally, the degradation rate of PCL is very slow (2 to 3 years), depending of the starting molecular weight of the device or implant, which minimize the probability of development of a severe inflammatory response due to the lack of accumulation of the by-products of the PCL (Woodruff & Hutmacher, 2010). Finally, the slow rate of hydrolytic cleavage of the PCL makes it suitable for longterm delivery extending over a period of more than 1 year (Sinha et al, 2004;Bourges et al, 2006;Ayres et al, 2007;Nair & Laurencin, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…These thermal properties were capitalized to fabricate drug delivery systems by means of processes such as melt molding (Ayres et al, 2007), extrusion (Bourges et al, 2006) without risking neither the polymer nor the drug molecular integrity due to an aggressive heating treatment (Sprockel et al, 1997;Lemmouchi et al, 1998;Carcaboso et al, 2010). Recently, the pharmaceutical companies have adopted the injection molding as a technique for designing polymeric drug delivery systems, due to the possibility to manufacture in large scale (Altpeter et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of methotrexate-loaded poly(ε-caprolactone) implants in Ehrlich solid tumor-bearing mice

Pereira

Barbosa

et al. 2013

Drug Delivery

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Context: Methotrexate (MTX) is used in the treatment of malignancies; however, its clinical application is limited by its toxic dose-related side effects. An alternative to overcome the toxicity of the MTX in healthy tissues is the design of an implantable device capable of controlling the delivery of this drug for an extended period within the tumor site. Objective: To develop methotrexate-loaded poly("-caprolactone) implants (MTX PCL implants) and to demonstrate their efficacy as local drug delivery systems capable of inhibiting Ehrlich solid tumor bearing mice. Materials and methods: MTX PCL implants were produced by the melt-molding technique and were characterized by FTIR, WAXS, DSC and SEM. The in vitro and in vivo release of MTX from the PCL implants was also evaluated. The efficacy of implants in inhibiting tumor cells in culture and the solid tumor in a murine model was revealed. Results and discussion: The chemical and morphological integrity of the drug was preserved into the polymeric matrix. The in vitro and in vivo release processes of the MTX from the PCL implants were modulated by diffusion. MTX diffused from the implants revealed an antiproliferative effect on tumor cells. Finally, MTX controlled and sustained released from the polymeric implants efficiently reduced 42.7% of the solid tumor in mice paw. Conclusion: These implantable devices represented a contribution to improve the efficacy and safety of chemotherapy treatments, promoting long-term local drug accumulation in the targeted site.

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Phase morphology of hydrolysable polyurethanes derived from aqueous dispersions

Cited by 93 publications

References 18 publications

Optimization of the structure of polyurethanes for bone tissue engineering applications

Optimization of the structure of polyurethanes for bone tissue engineering applications

Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis

Efficacy of methotrexate-loaded poly(ε-caprolactone) implants in Ehrlich solid tumor-bearing mice

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