Optimization of the structure of polyurethanes for bone tissue engineering applications

Bil, Monika; Ryszkowska, Joanna; Woźniak, Piotr A.; Kurzydłowski, Krzysztof J.; Lewandowska-Szumieł, Małgorzata

doi:10.1016/j.actbio.2009.08.037

Cited by 89 publications

(54 citation statements)

References 54 publications

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“…Figure 6 depicts the stress-strain curves for PUCO foams and the corresponding characteristic parameters are collected in Table 3. The mechanical properties of the synthesized PUCO foams can be dependent on many factors such as the cross-link density, crystallinity of the soft domain and the content of hard segment [39][40][41]. From Fig.…”

Section: Optical Microscope Images Of Puco Foamsmentioning

confidence: 99%

Synthesis of bio-castor oil polyurethane flexible foams and the influence of biotic component on their performance

et al. 2015

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A series of bio-based polyurethane flexible foams were synthesized by substituting polyether polyol with castor oil and polyethylene glycol (PEG). The influence of the castor oil component in the prepolymers on the structure and properties of the castor oil-based polyurethane flexible foams were investigated and compared. FTIR (Fourier transform infrared spectroscopy) results confirmed that bio-based polyurethane was successfully synthesized by castor oil, PEG and MDI (diphenyl methane diisocyanate), and its urethane group content decreased as the castor oil content increased from 40 to 60 wt.%. TG (thermogravimetry) and DTG (derivative thermogravimetry) results showed that the thermal degradation of the bio-based polyurethane flexible foams occurred at about 150, 320 and 420°C. The Young's modulus improved from 0.196 to 1.235 KPa and the compression resilience improved from 97.76 to 99.65 % with increased content of castor oil. Moreover, these bio-based foams exhibited lower water absorption and higher contact angle with increased castor oil content.

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Section: Optical Microscope Images Of Puco Foamsmentioning

confidence: 99%

Synthesis of bio-castor oil polyurethane flexible foams and the influence of biotic component on their performance

et al. 2015

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“…These scaffolds based on polyurethanes serve as a matrix for the cells to attach, to proliferate and to form a functional tissue that can be implanted into the patient [5]. Accordingly, polyurethane scaffolds have been used for generation of various tissue constructs, such as nerve conduits, [6,7] vascular grafts, [5,[8][9][10] cartilage [11][12][13] and cancellous bone graft substitutes [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis

Pinto

Cunha

Oréfice

et al. 2012

J Mater Sci: Mater Med

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The purpose of this study was to develop triamcinolone acetonide-loaded polyurethane implants (TA PU implants) for the local treatment of different pathologies including arthritis, ocular and neuroinflammatory disorders. The TA PU implants were characterized by FTIR, SAXS and WAXS. The in vitro and in vivo release of TA from the PU implants was evaluated. The efficacy of TA PU implants in suppressing inflammatory-angiogenesis in a murine sponge model was demonstrated. FTIR results revealed no chemical interactions between polymer and drug. SAXS results indicated that the incorporation of the drug did not disturb the polymer morphology. WAXS showed that the crystalline nature of the TA was preserved after incorporation into the PU. The TA released from the PU implants efficiently inhibited the inflammatory-angiogenesis induced by sponge discs in an experimental animal model. Finally, TA PU implants could be used as local drug delivery systems because of their controlled delivery of TA.

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“…As the hard segment contents increase, the polyurethane surface exhibits more phase separation, a higher content of urethane moieties, and a higher hydrophilicity. Biocompatibility results indicate that proliferation of human bone-derived cells (HBDC) cultured in vitro improves with increasing the hard segment content, while the osteogenic potential of HBDC decreases with an increasingly hard segment content [ 132 ]. Novel polyurethanebased injectable in situ curable polymer platform to determine its potential uses as a tissue-engineered implant is under investigation.…”

Section: Polyurethanesmentioning

confidence: 99%

Biodegradable Polymers for Focal Delivery Systems

Khan¹,

Challa²,

Langer

et al. 2013

Advances in Delivery Science and Technology

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Optimization of the structure of polyurethanes for bone tissue engineering applications

Cited by 89 publications

References 54 publications

Synthesis of bio-castor oil polyurethane flexible foams and the influence of biotic component on their performance

Synthesis of bio-castor oil polyurethane flexible foams and the influence of biotic component on their performance

Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis

Biodegradable Polymers for Focal Delivery Systems

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