Phase II Study on Voriconazole for Treatment of Chinese Patients with Malignant Hematological Disorders and Invasive Aspergillosis

Zhang, Xuezhong; Huang, Xin-En; Xu, Yanli; Zhang, Xiuqun; Su, Ailing; Shen, Zheng-Shan

doi:10.7314/apjcp.2012.13.5.2415

Cited by 39 publications

(9 citation statements)

References 28 publications

(24 reference statements)

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“…Five of the included studies clarified location-based differences. Zhang et al (2012) showed the elevation of risk to be essentially confined to left-sided colorectal cancer, with an odds ratio of 1.22 (95% CI 1.02, 1.45); this suggests that H. pylori infection may be associated with a small yet relevant risk increase in the left colorectal region. Buso et al (Buso et al, 2009) and Inoue et al (2011) showed that distal adenoma risk was significantly increased in the presence of H. pylori infection.…”

Section: Discussionmentioning

confidence: 89%

“…Statistical analysis was undertaken using the program Review Manager 4.2. We have enough experience in conducting medical researches, and have published some results elsewhere Yan et al, 2011;Zhang et al, 2011;Gong et al, 2012;Liu et al, 2012;Shu et al, 2012;Xu et al, 2012;Xu et al, 2012;Yu et al, 2012;Zhan et al, 2012;Zhan et al, 2012;Zhang et al, 2012;Chen et al, 2013;Dai et al, 2013;Deng et al, 2013;Gu et al, 2013;Huang et al, 2013;Lu et al, 2013;Sun et al, 2013;Wei et al, 2013;Yang et al, 2013;Yin et al, 2013;Yin et al, 2013).…”

Section: Statistical Analysis and Research Experiencementioning

confidence: 99%

See 1 more Smart Citation

Helicobacter pylori Infection and the Risk of Colorectal Adenoma and Adenocarcinoma: an Updated Meta-analysis of Different Testing Methods

Chen¹,

Xu²,

Ding³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 89%

Section: Statistical Analysis and Research Experiencementioning

confidence: 99%

Helicobacter pylori Infection and the Risk of Colorectal Adenoma and Adenocarcinoma: an Updated Meta-analysis of Different Testing Methods

Chen¹,

Xu²,

Ding³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…The above hypothesis test was a two-sided test; P<0.05 was considered as statistically significant. We have enough experience in conducting medical researches, and have published some results elsewhere Yan et al, 2011;Zhang et al, 2011;Gong et al, 2012;Liu et al, 2012;Gu et al, 2013;Shu et al, 2012;Xu et al, 2012;Xu et al, 2012;Yu et al, 2012;Zhang et al, 2012;Chen et al, 2013;Dai et al, 2013;Deng et al, 2013;Huang et al, 2013;Lu et al, 2013;Sun et al, 2013;Wei et al, 2013;Wu et al, 2013;Yang et al, 2013;.…”

Section: Statistical Methods and Research Experiencementioning

confidence: 99%

CXCL12-CXCR4 Promotes Proliferation and Invasion of Pancreatic Cancer Cells

Shen

Zheng²,

Lu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Objective: CXCL12 exerts a wide variety of chemotactic effects on cells. Evidence indicates that CXCL12, in conjunction with its receptor, CXCR4, promotes invasion and metastasis of tumor cells. Our objective was to explore whether the CXCL12-CXCR4 biological axis might influence biological behavior of pancreatic cancer cells. Methods: Miapaca-2 human pancreatic cancer cells were cultured under three different conditions: normal medium (control), medium + recombinant CXCL12 (CXCL12 group), or medium + CXCR4-inhibitor AMD3100 (AMD3100 group). RT-PCR was applied to detect mRNA expression levels of CXCL12, CXCR4, matrix metalloproteinase 2 (MMP-2), MMP-9, and human urokinase plasminogen activator (uPA). Additionally, cell proliferation and invasion were performed using CCK-8 colorimetry and transwell invasion assays, respectively. Results: CXCL12 was not expressed in Miapaca-2 cells, but CXCR4 was detected, indicating that these cells are capable of receiving signals from CXCL12. Expression of extracellular matrix-degrading enzymes MMP-2, MMP-9, and uPA was upregulated in cells exposed to exogenous CXCL12 (P<0.05). Additionally, both proliferation and invasion of pancreatic cancer cells were enhanced in the presence of exogenous CXCL12, but AMD3100 intervention effectively inhibited these processes (P<0.05). Conclusions: The CXCL12-CXCR4 biological axis plays an important role in promoting proliferation and invasion of pancreatic cancer cells.

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“…Next, denaturing high-pressure liquid chromatography (dHPLC) was performed for each amplicon using the The WAVE Systerm 3500 (Transgenomic, Inc., Glasgow, UK). Running conditions were optimized based on the Navigator software MYH Polymorphisms and Sporadic Colorectal Cancer: A Case- We have enough experience in conducting medical researches, and have published some results elsewhere Yan et al, 2011;Zhang et al, 2011;Gong et al, 2012;Liu et al, 2012;Shu et al, 2012;Zhan et al, 2012;Zhan et al, 2012;Xu et al, 2012;Xu et al, 2012;Yu et al, 2012;Zhang, et al, 2012;Zhang et al, 2012;Chen et al, 2013;Dai et al, 2013;Deng et al, 2013;Gu et al, 2013;Huang et al, 2013;Lu et al, 2013;Sun et al, 2013;Wei et al, 2013;Wu et al, 2013;Yin et al, 2013;Yin et al, 2013).…”

Section: Methodsmentioning

confidence: 99%

Role of MYH Polymorphisms in Sporadic Colorectal Cancer in China: A Case-control, Population-based Study

Liu¹,

Huang²,

Xu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Purpose: Biallelic germline variants of the 8-hydroxyguanine (8-OG) repair gene MYH have been associated with colorectal neoplasms that display somatic G:CgT:A transversions. However, the effect of single germline variants has not been widely studied, prompting the present investigation of monoallelic MYH variants and susceptibility to sporadic colorectal cancer (CRC) in a Chinese population. Patients and Methods: Between January 2006 and December 2012, 400 cases of sporadic CRC and 600 age-and sex-matched normal blood donors were screened randomly for 7 potentially pathogenic germline MYH exons using genetic testing technology. Variants of heterozygosity at the MYH locus were assessed in both sporadic cancer patients and healthy controls. Univariate and multivariate analyses were performed to determine risk factors for cancer onset. Results: Five monoallelic single nucleotide polymorphisms (SNPs) were identified in the 7 exon regions of MYH, which were detected in 75 (18.75%) of 400 CRC patients as well as 42 (7%) of 600 normal controls. The region of exon 1 proved to be a linked polymorphic region for the first time, a triple linked variant including exon 1-316 GgA, exon 1-292 GgA and intron 1+11 CgT, being identified in 13 CRC patients and 2 normal blood donors. A variant of base replacement, intron 10-2 AgG, was identified in the exon 10 region in 21 cases and 7 controls, while a similar type of variant in the exon 13 region, intron 13+12 CgT, was identified in 8 cases and 6 controls. Not the only but a newly missense variant in the present study, p. V463E (Exon 14+74 TgA), was identified in exon 14 in 6 patients and 1 normal control. In exon 16, nt. 1678-80 del GTT with loss of heterozygosity (LOH) was identified in 27 CRC cases and 26 controls. There was no Y165C in exon 7 or G382D in exon 14, the hotspot variants which have been reported most frequently in Caucasian studies. After univariate analysis and multivariate analysis, the linked variant in exon 1 region (p=0.002), intron 10-2 AgG (p=0.004) and p. V463E (p=0.036) in the MYH gene were selected as 3 independent risk factors for CRC. Conclusions: According to these results, the linked variant in Exon 1 region, Intron 10-2 AgG of base replacement and p. V463E of missense variant, the 3 heterozygosity variants of MYH gene in a Chinese population, may relate to the susceptibility to sporadic CRC. Lack of the hot-spot variants of Caucasians in the present study may due to the ethnic difference in MYH gene.

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Phase II Study on Voriconazole for Treatment of Chinese Patients with Malignant Hematological Disorders and Invasive Aspergillosis

Cited by 39 publications

References 28 publications

Helicobacter pylori Infection and the Risk of Colorectal Adenoma and Adenocarcinoma: an Updated Meta-analysis of Different Testing Methods

Helicobacter pylori Infection and the Risk of Colorectal Adenoma and Adenocarcinoma: an Updated Meta-analysis of Different Testing Methods

CXCL12-CXCR4 Promotes Proliferation and Invasion of Pancreatic Cancer Cells

Role of MYH Polymorphisms in Sporadic Colorectal Cancer in China: A Case-control, Population-based Study

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