Phase II study of capecitabine plus oxaliplatin (CapOX) as adjuvant chemotherapy for locally advanced rectal cancer (CORONA II)

Hattori, Norifumi; Nakayama, Goro; Uehara, K.; Aiba, Toshisada; Ishigure, Kiyoshi; Shimizu, Eiji; Tojima, Yuichiro; Kanda, Mitsuro; Kobayashi, Daisuke; Tanaka, Chie; Yamada, Suguru; Koike, Masahiko; Fujiwara, Michitaka; Nagino, Masato; Kodera, Yasuhiro

doi:10.1007/s10147-019-01546-3

Cited by 7 publications

(5 citation statements)

References 30 publications

(39 reference statements)

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“…They proposed that the trophic effect of gastrin over gastric mucosa could induce the development of gastric adenocarcinoma. Also, Yanagawa et al [ 19 ] proposed that immunosuppression induced by a lymphoma could lead to the development of adenocarcinoma [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Gastric collision tumour with probable ectopic pancreatic origin

Gonzáles¹,

Arroyo-Gárate²,

Estrella³

et al. 2022

ecancer

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Introduction Mixed histology tumours are rarely found in the stomach. Of these, collision tumours are mainly composed of adenocarcinomas and sarcomas or lymphomas. This is the seventh case reported in the literature of an acinar cell carcinoma arising from an ectopic pancreas located in the stomach and the first described within a collision tumour. Clinical case We present the case of a 58-year-old female patient diagnosed with gastric cancer who, after undergoing a total gastrectomy, presented with a pathology report describing findings compatible with gastric collision tumour with components of tubular adenocarcinoma and acinar cell carcinoma of probable pancreatic ectopic aetiology. Discussion At the beginning of the 20th century, collision tumours were rarely described. Those located in the stomach are an infrequent pathology and are rarely diagnosed preoperatively. A collision tumour is composed of two independent neoplastic tissue with tumour areas separated in two different histological patterns and, in case of metastasis, this separation must also be clearly identified. There are different theories about its carcinogenesis and the debate regarding the ideal treatment is still ongoing. Conclusion This is the first report of a malignant gastric tumour with probable heterotopic pancreatic origin that collides with gastric adenocarcinoma.

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Section: Discussionmentioning

confidence: 99%

Gastric collision tumour with probable ectopic pancreatic origin

Gonzáles¹,

Arroyo-Gárate²,

Estrella³

et al. 2022

ecancer

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“…In the SPS group, diverting ileostomy was performed as appropriate, which was reversed 3-4 months after surgery or after administration of adjuvant chemotherapy. Neoadjuvant chemotherapy was given for some stage II/III patients as a part of our clinical trial or daily practice [15,16], whereas preoperative chemoradiotherapy (CRT) was indicated for limited patients when the radial margin was involved after neoadjuvant chemotherapy [17].…”

Section: Treatmentmentioning

confidence: 99%

Renal Dysfunction after Rectal Cancer Surgery: A Long-term Observational Study

Sando

Uehara

et al. 2023

J Anus Rectum Colon

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Objectives: Despite the high incidence of urinary dysfunction (UD) after rectal surgery, it remains questionable whether UD causes future chronic kidney disease (CKD). This study aimed to clarify the long-term trends in renal function and risk factors for future CKD after rectal resection. Methods: For comparison, patients who underwent rectal resection (n = 129) and colectomy (n = 127) between 2006 and 2017 were identified. The estimated glomerular filtration rate (eGFR) ratio was calculated as the ratio to the baseline. "eGFR ratio < 0.75 at 3-year" was adopted as a surrogate indicator of future CKD. Results: eGFR ratio significantly decreased in the rectal cohort compared with the colon cohort at 1.5 years (0.9 vs. 0.95, p = 0.008) and at 3 years (0.85 vs. 0.94, p < 0.001). Although the preoperative prevalence of CKD was lower in the rectal than the colon cohort (13.9% vs. 23.6%, p = 0.055), it was similar at 3 years (29.5% vs. 30.7%). In multivariate analysis, females, and cT4 were independent risk factors for future CKD, but UD itself was not. Conclusions: Postoperative eGFR significantly decreased after rectal cancer surgery compared to colectomy. The prevalence of CKD more than doubled at 3 years after rectal resection. The female sex and cT4 tumor, instead of the UD, were independent risk factors for future CKD.

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“…On the contrary, FOLFOX requires hospitalising the patient for 4 days per course, raising its cost. However, unsupervised outpatient CTx with capecitabine involves a risk of irregular treatment and can be inappropriate for some patients, leading to worse outcomes [19][20][21]. Administering SCRT requires specialised techniques, such as IMRT or VMAT, which costs less, and there is no marked difference between them.…”

Section: (Continued)mentioning

confidence: 99%

Cost analysis of total neoadjuvant therapy with 5 × 5 Gy radiation therapy versus conventional chemoradiotherapy for locally advanced rectal cancer among Peruvians

Robles-Díaz¹,

Changra²

2022

ecancer

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Background and Objectives Conventional long-course radiotherapy (LCRT) and a new paradigm of short-course radiotherapy with total neoadjuvant therapy (SCRT-TNT) are used in locally advanced rectal cancer (RC). There are few economic assessment reports available on TNT that focus on cost analysis in a country with limited funding for healthcare systems. The objective of this study was to perform a cost analysis comparing SCRT-TNT versus LCRT. Materials and Methods In 2020–2021, a prospective registry was created to document RC patients who received neoadjuvant therapy and the costs of cancer treatments, transportation and the time patients and family members spent in the hospital. This registry outlined the direct and indirect costs of LCRT versus SCRT-TNT. Results LCRT and SCRT-TNT regimens have direct costs that range from S/.5,993.30 to S/.27,928.36 and from S/.3,409.81 to S/.18,159.42, respectively. FOLFOX regimens are the most expensive. Administering radiotherapy in 28 3D sessions and 5 sessions of intensity-modulated radiation therapy (IMRT) or volumetric-modulated arc therapy (VMAT) sessions costs S/.2,603.88, S/.1,277.19 and S/.1,027.77, respectively. The indirect cost of FOLFOX regimens is twice that of the similar modality that combines irradiation and Oxaliplatin IV and Capecitabine VO (CAPOX). SCRT-TNT regimens with CAPOX reduce costs by at least 50%, while SCRT-TNT regimens with FOLFOX reduce costs by 32%. Conclusion Despite using IMRT/VMAT, SCRT-TNT is a less expensive approach for patients with RC when compared to LCRT. The costs to patients using SCRT-TNT are much lower, but it is also a better option because it saves hospital resources.

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Phase II study of capecitabine plus oxaliplatin (CapOX) as adjuvant chemotherapy for locally advanced rectal cancer (CORONA II)

Cited by 7 publications

References 30 publications

Gastric collision tumour with probable ectopic pancreatic origin

Gastric collision tumour with probable ectopic pancreatic origin

Renal Dysfunction after Rectal Cancer Surgery: A Long-term Observational Study

Cost analysis of total neoadjuvant therapy with 5 × 5 Gy radiation therapy versus conventional chemoradiotherapy for locally advanced rectal cancer among Peruvians

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